alpha cynucleo in is seen in the panel so we see fewer of those cells staining for this marker for dopa-- if we express it, they become compromised and sick and some people you can even see movement disorders in these flies. so in fact, by expressing this gene that is associated with human parkinson a disease we can get effects in the fly that-- fly that look like core effects of parkinson a disease so i would like to show another example that is showing an effect on climbing behavior. so this is using a gene in the fly that is involved in als. so als is another reall really-- another-- lou geric's disease. lou gehrig's disease it is another very debilitating disease. and it leads to loss of voluntary movement control and eventually paralysis. >> this is what tony jett suffers from. >> right. so if we look at the behavior of normal flies. normal flys will climb upwards. they have this robust negative geo tactic response but the flys that are defect piv in this human als gene, these flys are alive and they're moving but they can no longer climb. so this is a remarkable example of sort of