dr. bigelow: one can become physically dependent on surprisingly low doses of caffeine. it appears that only about 100 milligrams a day is sufficient to produce physical dependence. that's the equivalent of two or three sodas, or maybe one or two cups of coffee. because the drug is so readily available, it doesn't produce a big problem. so it's an example of a well tolerated, widespread drug of dependence that's just accepted and used in society without major problems. dr. mccaul: among drugs other than alcohol, marijuana is the most prevalent drug of choice in our society. so it does receive widespread use at this point in time particularly among younger people. but that doesn't make it a safe drug any more than alcohol, which is both legal and widespread in its use, is a safe drug. marijuana has toxic effects, because of its route of administration. the inhalation is just as nasty and toxic as cigarette smoking. dr. miotto: there appears to be an increased risk of cancer, of bronchitis, of asthma. the problem is compounded in that many marijuana smokers also smoke ciga