dr. francis collins, dr. otis brawley, we thank you all three. >> thank you. >> thank you. >> thanks, judy. >> woodruff: next, the motion picture academy today named its top picks for the best performances and films of 2015. jeffrey brown has our look at who's in this year's field, and- - getting just as much attention-- who's not. >> when it comes to oscar nominations this year, it is a very cruel world, indeed. "the revenant," a revenge tale set in the american wilderness in the 1800s, ghaind the most nominations, 12 in all, including for best picture, best director alejandro g. inarritu, who won last year for "birdman," and in the leading actor category for leonardo dicaprio, a megastar who famously has never won an oscar. the second most honored film with 10 nominations portrayed a different kind of struggle for survival. "mad max: fury road" is set in a not-so-distant future that we can all only hope to avoid. it's a sequel to the popular trilogy that began in 1979. director george miller, who also creat

dr. collins and i are here and i have had an opportunity to speak with my friend, she really is my friend, dr. gutman. i, like so many of you and maybe members of the press and familys, i'm a typical in that my family has been touched by cancer. some family members have survived and some have not. my mother, god love her, used to have an expression. joe a little bit of knowledge is , a dangerous thing. when you are engaged with someone you love who is fighting for their life, you become acquainted with at least the parameters of what they are dealing with. and as death will tell you, -- dad will tell you you do , everything in your power to be able to learn as much about the fight that is underway as you can. and so i want to make it clear, when the president set up -- when i decided not to run for president, i indicated in the rose garden that when i made that announcement that had i been president, one of the things i would devote my administration to was a manhattan project, a lot of moon shots on cancer. but the truth of the matter is i believe from my exposure over two years of my so

dr. jennifer collins, owner of gramercy allergy and asthma. good to have you both with us today. >> thank you. >> well, julie, let me first ask you what the key findings are for american express open report. >> well, as you just said, lots and lots of women going into business, starting and growing their businesses at a rate faster than the average. one of the most astounding findings is the growth in firms owned by women of color. they're now one in three women-owned firms, and just 15 years ago, they were one in six. so, there's tremendous growth in the diversity of women-owned firms. >> why do you think it's taken this long? i mean, i -- just -- you know, when i think of -- and, boy, oh, boy, it sounds -- i mean this sexist in a good way, not in a bad way -- i think of growing up and the responsibility that my mother has always had -- and thank goodness she's still with us -- and i think of the way she managed the budget, and i always think, that's the person who knows how to run a business. >> right. [ laughter ] >> okay, so, i'm, "right o

dr. francis collins is joining us. you were here on a real mission of hope. you talke about how we were going to cure cacaer. you said president obama wants to make sure we advance this. we have been hearing it since 1971 from president nixon, what gives us more hopehis time? >> for me as scientist, i do believe we're at an inflection point for cancer. canter is not one disease, it's make progress at different paces. we do have newer eyes about how to find answers, treatmts, and cures compared to a few years ago. maybe people are sin kal. when it was declared we didn't have a clu.u. now wee have their number. >> how much of this is because of what we now know about genetics. you're the former ahead of the human genome project. >> that is a big part of it. cancer is a disease of the genome. it happens because of mistakes in dna that happen in vulnerable places that cause a cell to grow when it should have stopped so we can look at the tumor and say what genes arere involved in that person's cancer and how can you match that with a strategy to stop that growth

dr. collins, thank you so much for your time. >> up next, "on the money." we'll ask bill gates and bono about their charities and making the world a better place. wyff your path to retirement... may not always be clear. but at t. rowe price, we can help guide your retirement savings. for over 75 years, investors have relied on our disciplined approach to find long term value. so wherever your retirement journey takes you, we can help you reach your goals. call a t. rowe price or your advisor ...to see how we can help make the most of your retirement savings. t. rowe price. invest with confidence. every auto insurance policy has a number. but not every insurance company understands the life behind it. those who have served our nation have earned the very best service in return. usaa. we know what it means to serve. get an auto insurance quote and see why 92% of our members plan to stay for life. >>> welcome back. one is a rock star, the other is the richest man in the world. they both are fighting poverty we spoke with bill gates and bono in our "face to fac

dr. collins just said in terms of this immunotherapy now. dr. o'ro i will ask arke [inaudible] and segue into immunotherapy. >> i am sorry for your personal loss. it is terrible to have had to bear witness to this. i do not have to tell you how important getting a cure for glioblastoma is. i am glad you chose penn. we do have a collaborative environment. table, it is the unique and it places us in a good position. let me tell you why i am excited about glioblastoma for the first time over the last 12 months or so. is at the -- is that the command center and privileged. we found that is not the case. i will get into that. this is a unique opportunity to identify what the relationship is between the immune system and the nervous system. it is huge question -- a huge question. glioblastoma and other neurological diseases. one of the basic research elements of our projects is to look at how those two systems relate and interact. it is huge question. with glioblastoma, immunotherapy has become very much a hot topic. what we are doing that is unique i

dr. francis collins is the direct of the nih. thanks for being here. you were here with joe biden. talked about how here going to cure cancer. this is something that president obama said he wants to make sure we advance this. we've been hearing this in 1971 from president nixon. >> what's the deal here. for me as a scientist, i do believe we're at infliction point for cancer. let's be clear, cancer not one disease. it's hundreds of diseases. we are at a point where we have ideas about how to find answers, treatments and cures, compared to where we were a few years ago. maybe people are a little cynical because it has been a time since the war on cancer, but when it was declared we didn't have a clue what was going on. now we know what is going on inside the cancer cell. >> how much of this has given us a new glimpse? >> that's a big part of it. cancer a disease of the d nome. that happened in dna in vulnerable places that caused the cell to grow that should have stopped. now, we're able to look at exactly what are the changes and which genes are involved in that person's cancer and

dr. collins and then i would like to open up and educate me.i would like you to talk about what you think i should most be doing as i put this task force together and my commitment is not just for the next 12 months. my commitment to do this and i have been stunned by the response worldwide. you have seen some of it. i have been stunned at the overwhelming response welcoming me to be a facilitator and convener. i plan on doing this the rest of my life. [applause] >> tomorrow, donald trump will hold a campaign rally in portsmouth, new hampshire. you can watch the live coverage starting at 11:30 a.m. eastern on c-span. >> book tv has 48 hours of nonfiction books and authors every weekend on c-span2. here are some programs to watch out for this weekend. watch thet 1:30 p.m., coverage of the second annual bill of rights book festival on the national constitution center in philadelphia. at 10 p.m., a pulitzer prize-winning journalist assesses her book, a story about china's most radical experiments about the impact of china's recently discontinued o

dr. collins and then i would like to open up and educate me.i would like you to talk about what you think i should most be doing as i put this task force together and my commitment is not just for the next 12 months. my commitment to do this and i have been stunned by the response worldwide. you have seen some of it. i have been stunned at the overwhelming response welcoming me to be a facilitator and convener. i plan on doing this the rest of my life. [applause] >> tomorrow donald trump will hold a campaign rally in portsmouth new hampshire pretty couldn't watch our live coverage starting at 11:30 a.m. eastern time on c-span. mondays martin luther king jr. day. with congress not in session we have featured programs on all three c-span networks. on c-span at 11:30 a.m. eastern live coverage of british house of commons debate on whether to ban donald trump from the country. that debate is expected to last three hours. on book tv, university of wisconsin professor william t jones and his book the march on washington. jobs, freedom, and the produc

dr. collins's compliments of your work and appreciate your straightforwardness. a couple things. someone asked regarding backlog applications, 85% of those who were freed this legislation had some action. that means 15% do not. if you are one of the 15% you are like oh my gosh! secondly 85% of the action might have been to take them back. any comments on why did 15% is purgatory and 85 presented cetera? >> when we negotiated this agreement with industry they were realistic that we could not reduce thousand applications in three years and higher at thousand people and rebuild our drug system and reorganize, all of which we have done so the goal was to clear out 90% of the bat on applications by the end the program, five years. that was the agreed upon bowl with industry. with no other intermediate goals. what we have done, we have already gone back to them or worked on 82% of them. >> don't let me interrupt. i have so many questions. i am told by industry, have them saying what i am told, not what i know. when you complete low-quality applications they are low-quality because in t

senator collins: thank you, mr. chairman. dr. woodcock, first let me thank you for your many years of public service and all that you're doing to expedite generic drug applications in order to make prescription drugs more affordable for consumers. i know that you're familiar with the investigation, the aging committee is doing into the sudden, very aggressive price spikes that some companies have implemented on drugs that have been on the market for literally decades. one is 63 years old. 5,000% there's been a increase in its price bye buy a company that invested not one dime -- price by a company that invested not one dime in the

collins? >> thank you, mr. chairman. dr. woodcock, let me thank you for your many years of public service and all you're doing to kpe indict generic drug applications, to make them more affordable for consumers. i know you're familiar with the investigation the aging committee is doing into the sudden very aggressive price spikes that some companies have implemented on drugs that have been on the market for literally decades. one is 63 years old and yet there's been a 5,000% increase in its price by a company that invested not one dime into the research and development that led to this drug. i'm concerned that our current regulatory structure doesn't take into account situations where there is essentially a market failure, because the population of patients may be small. there's no generic application. whether it's pending or not it just hasn't happened. now, i know that the fda currently provides an express lane review for certain generic drug applications, including first generics and those that would help solve medical dr

dr. mickey collins today, and time will tell. i know the steelers are putting antonio's health first.ective of him, and i'm sure that everybody here will do the right thing with antonio's health being the most important quality. or most important criteria here. >> drew, quickly if you can, what is the expected impact of this rams move on other l.a. sports teams, on the lakers and the clippers even? is this going to be a rising tide lifting all boats with the new sport coming in, or might there be negative effects? >> i don't think it will have a negative effect. usually the big markets can support the different leagues. baseball, hockey, basketball, football. obviously the nfl is pretty much the big dog in just about every market that it's in. i would say. i imagine the los angeles rams will quickly become the most popular sports team in los angeles. >> drew, it's good to see you with so much. we need you for the whole hour next time. drew rosenhaas joining us. >> my pleasure. >> thanks a lot. >> the dow continues to fall here. we're down almost 100 points. near session lows. be right

much influenced by collins, philadelphia's dr. benjamin rush observed certain note stimulated brain functions such as long-term memory. both the acts of listening and singing then mattered because music was a stimulus to which the human ear could not help but respond. music stimulated the body and generated particular feelings. with those preliminary ideas in mind, i invite you to listen to one of the most most important political songs of the time, "hail columbia." it was written to accompany the present's march. please give your attention to the performers from the division of music and the meadows school of art. ♪ >> ♪ hail columbia, happy land hail, ye heroes, heav'n-born band, who fought and bled in freedom's cause, who fought and bled in freedom's cause, and when the storm of war was gone enjoy'd the peace your valor won let independence be our boast, ever mindful what it cost; ever grateful for the prize, let its altar reach the skies firm, united let us be, rallying round our liberty, as a band of brothers joined, peace an

senator collins: that's why i ask it. dr. woodcock: part of our problem is knowing whose market and when. these people come and in out of the market. if they don't withdraw their applications hard for us to say whether they are marketing unless we get notified of a shortage. which case it becomes clear. senator collins: the other issue, related issue, that i ask you to work with us on as we try to come up with solutions to these market failures is figuring out what the length of time for an expedited approval should be that would discourage the company from buying up a decade's old drug and increasing the cost of t if it's a short enough time, it's not going to be worth the amount of money that the manufacturer -- they are not manufacturers, they are more like what i call hedge fund pharmaceutical companies. would pay to get the right -- rights to that drug. one of the ideas that i'd like to work with you on is whether there's a way to take away the incentive by having this expedited approval that would encourage the generic

dr. woodcock for that. senator collins in the committee on ageing you and senator mccaskill have done a lot of work on this subject. we know also you don't have legislative authority, so we welcome the work product from your committee over here as we work on our legislation. senator casey? senator franken? >> thank you. i appreciate senator collins' questions, and part of your answer on -- it seemed to suggest that the data that you have on the market is not totally complete. >> that's correct. uh-huh. >> okay. and is there anything you can do -- is an aspiration of yours to make that data complete, more complete? >> it's very difficult to figure these things out because as senator -- >> who would do that, do you think? >> well, i believe senator collins' hearing they talked about the contracts and the rebates and the -- all the different things in the u.s. distribution chain that nobody really knows the answer to. the insurers i think would really like to know how these drugs are moving and what is actually being paid for

dr. francis collins told me that if we could have 5% real growth in biomedical research at the n.i.h. for ten years, he could light up the scoreboard. we were on the cusp of so many discoveries that this was an opportunity if the investment were made to really have some medical breakthroughs. i took that to heart, introduced a bill called the american cures act, and i'm sure senator blunt and many of my colleagues are tired of hearing about it, but the notion is a ten-year commitment by congress, 5% real growth each year when it comes to the n.i.h. as it turns out, this year we are knocking on the door of doing just that with the investment that was made by the appropriation bill. this investment is almost $42 billion in biomedical research. $32 billion at the national institutes of health. that's a 6.6% increase over last year. $7 billion from the centers for disease control and prevention, 4.5% increase over the fiscal year 2015. there are two other areas of research opportunities in biomedical research. the veterans medical and prosthetics research program and the department of def

dr. francis collins. he talked about the areas that look the most promising.video clip] >> having had the privilege of leading the human genome project, i cannot help but mention that one. it is the case since cancer is a disease of the genome, and we have the technology to read out why a good cell goes bad. we have been recently able to do that at scale. is the area that shows the most remarkable promise at the present time. the people credit to at this table, institution, and others. host: you are next, good morning. caller: good morning. good morning. i'm pleased to hear francis collins is on board. one of my objections has been removed. cancer is not one disease. it is a number of diseases. for many years, tuberculosis was lumped into cancer until the causative agent, which was a small micro was identified -- a small microbe was identified. my father was diagnosed and it was -- it ended up that my father had some physicians came in and he explained to him that there are things that you eat that will change the results of your test and give you a false posi

collins. >> thank you, mr. chairman. dr. hepburn, particularly in rural states like maine, patients with serious mental illness all too often lack access to the care that they need. and as i look at federal policies, at times federal policies exacerbate the problem of access. we still don't treat mental illness the same way we treat physical illness in this country from the perspective of federal reimbursement policies and programs, which is pretty stunning in this day and age. you mentioned that congress recently passed senator cardin's bipartisan bill, which i was pleased to be a co-sponsor of, which extends anhó(ms÷ demonstration project that helps address the psychiatric bed shortage that ms. blake has talked about and improve access to critical mental health care services and support. maine is one of the pilot states under that program and has already seen very promising results because federal medicaid matching payments are being allowed for free-standing psychiatric hospitals for certain emergency psychiatric cases. s

collins. >> thank you, mr. chairman. dr. hepburn particularly in rural states like maine, patients with seriously mental illness all too often lack access to the care that they need. as i look at federal policies, at times federal policies exacerbate the problem of access. we still don't treat mental illness the same way we treat physical illness in this country, from the perspective of federal reimbursement policies and perhaps. which is pretty stunning in this day and age. you mentioned that congress recently passed senator card dip's bipartisan bill, which pleased to be cosponsor of which extends an important demonstration project that helps address the psychiatric bed shortage that ms. blake talked about and improved access to critical mental health care services and support. maine is one of the pilot states under that program and has already seen very promising results because federal medicaid matching payments are being allowed for free-standing psychiatric hospitals for certain emergency psychiatric cases. similarly t

much influenced by collins, philadelphia's dr. benjamin rush observed certain note stimulated brain functions such as long-term memory. both the acts of listening and singing then mattered because music was a stimulus to which the human ear could not help but respond. music stimulated the body and generated particular feelings. with those preliminary ideas in mind, i invite you to listen to one of the most most important political songs of the time, "hail columbia."