dr. giordano said we are adhering to state-of-the-artery search methodology. in this manner i think we will be able to get adequate information by rigorously patrolling settings opinionmizing conditions focusing on safety parameters. i think that's -- that's the proper way to proceed, very cautiously very carefully and very clearly focus on not repeating some of the mistakes of the past. >> james, one of the things that's fascinating to me in the research is that a lot of people who are treated with sylisibin only need one or two treatments. why makes it so effective in a short-term? >> its effective. the two buzz words is it has to be pragmatically done very very sound and it needs to be prudently carried through. i think the first step, the pragmatism is interesting because in the past 10 or 15 years, we have learned so much more about mechanisms of the brain on a variety of levels from the very very small to the very, very large and understanding more about how these compounds works. >> helps us adjust the dotes. what happens to happen is come pounldz such