>> well, as dr. hodes says the current drugs on the market are called systematic drugss.they treat some of the symptoms of alzehimer's disease but what we really need to have an impact on this disorder is to have disease-modifying therapies and there are many of these. 50 to 1200 at any given time are under investigation by a variety of biotechs, pharmaceutical industry these trials are ongoing and it just takes one two of these to hit to have an impact on the underlying disease process that will affect the numbers we've seen in this study from the rand corporation. >> brown: i'm imagining that many people watching this have personal connections or concerns about this. what do people look for? i'm going back to the definition of sdhaepl in a sense. what should people look for in themselves and loved ones when you talk about short-term memory loss, long-term memory loss. what are the signals? >> well, one of the areas of progress in the last few years has been our ability to detect the disease at an earlier and earlier state so we now don't wait for the dementia stage but