dr. mccabe's professional career.in 1976, when i was a fellow at the university of colorado and was asked by dr. marianne guggenheim, a pediatric neurologist, if we would see these two brothers who were on the clinical research center in the pediatric unit, she said, "must be genetic. they look the same. they've got the same neurological problems." chris had gotten real ill, and they didn't know why. they thought maybe he'd been, you know, abused and stuff. so we brought him to-- to the hospital and she took a look at the little one-- wasn't walking. she said there's something wrong. only 2 and 3 years old, scotty and chris were short, physically weak, and severely retarded with iq's in the 30's. they had triangular, elfin faces, crossed eyes, and sweet dispositions. those were the first two brothers with this contiguous gene syndrome that i've spent my whole career studying, as mccabe and his associates were to learn, christopher and scotty had a rare combination of three genetic disorders. but at first their conditi