human efficacy studies are not feasible. fda's animal rule is important for such products which is why i emphasized the importance of finalizing the animal rule guidance before this committee. as far as i can tell there has been no further movement on this issue since that hearing. i would like to ask you, when is the animal rule guidance going to be finalized as required by law? >> let me first begin by saying thank you for the work you've done to advance public health preparedness and the development and availability of important medical countermeasures. the animal rule is an aspect of this that is key. we need to develop countermeasures against certain threats where the disease may not exist in nature and we would never want to expose people to the disease to actually see if the new drug or vaccine actually works. we have taken the animal role very seriously. it is one of those areas of regulatory science that is challenging because we want to be able to know that using animal data, which is often imperfect, we can make a

as you know human efficacy studies are not feasible and some medical countermeasures. therefore fda's animal rule is particularly important for such products, which is why i emphasize the importance of finalizing animal rule guidance with dr. boryo before this committee. as far as i can tell there's been no further movement on this issue since that hearing so i'd like to ask you, when is the animal rule guidance going to be finalized as required by law? >> well let me first begin by thanking you for all the extraordinary work you've done to advance public health preparedness, and the development, and availability of important medical countermeasures and the animal rule, as you note, is an aspect of this that is key because we do need to develop medical countermeasures against certain threats where the disease may not exist in nature, and would certainly never want to expose people to the disease to actually see if the new drug or vaccine, actually works. we have taken the animal rule very seriously. it's one of those areas of regulatory science that is challengeing bec

the fda is responsible for promoting and protecting the public health by ensuring the safety, efficacy, and security of human and veterinary drugs, vaccines, biological products. medical devices, the safety of most of the food supply, the blood supply, and other tissue products, cosmetics, and products that emit radiation. most recently, fda is responsible for regulating the manufacturing marketing and distribution of tobacco products. some things might surprise you about some of the products that we regulate. ranging from things like bionic eyes and replacement body parts that are made by 3-d printers. to the use of medicinal leeches, that was one that surprised me. we oversee the safety of the food the dignitaries needs at government events, like the state of the union, i just learned last week that we are responsible for regulating the waste that is discarded from moving trains. so you can see that wherever you are, the fda is working for you. but is not just the diversity of the products that we oversee that someone might find surprising. it's the way that we bring our enormous exp

according to the doctor there is still little data verifying its efficacy. >> a major obstacle in using, honestly i see them as agency the first application is to protect the patient. >> dr. cilio is testing as pooh single compound. the pharmacological compound is made by request companies in canada. low levels of thc and other comab cannabinoids. >> we decided to use pure cannabidiol. we thought it was safer. we know how much we are giving so we can evaluate the effect. and also, we thought it was the time to do tonight a way that was more scientifically sound. >> how do you feel about the gw trials that are happening here in the u.s? >> the worst thing that could happen is for that product to be too different from this one. and if it doesn't work and then the scientific and medical communities come back and say, oh, we already looked at that, so just pass it by, that's the worst thing that can possibly happen. >> people tend to see only possible benefits. and i understand, because when you have a child with intractable epilepsy your hope never ends but people have to understand that r

that 12-step is not aa. 12-step facilitation is not aa. >> the efficacy is actually coming out of theby aa as opposed to the specific steps. but i think i would urge people to read this article. in heroin, we're in a situation where people are struggling so hard to deal with this. and there is a lot of -- a lot of unknowns that we are legislating off of in our policies generally. thank you both. >> thank you so much. >>> "the rachel maddow show" starts right now. >> chris, you are in land mine territory there. in terms of talking about stuff that upsets people. i want to see your inbox tonight. well done, man. thanks to the viewers at home for joining us this hour. >>> if you are a u.s. taxpayer, add this to the list of things that you own, that maybe you did not know that you owned. you own the united states government's explosive destruction system. eds for short. the explosive destruction system is a chamber with stainless steel walls that are up to nine inches thick. thought to be totally indestructible. thought to be totally blast proof.

there may an rift widening between the united states and europe over the efficacy of putting sanctions on russia. but this particular list of sanctions probably won't make a difference at all. >> frosty relations in one of russia's most significant fishing ports. the embargo on imported seafood has sent prices soaring in the arctic and that has left buyers and suppliers struggling. >> a statue of a young woman watches the port's cold waters, waiting for her fisherman to return. this is the largest city inside the arctic circle. it helps support a large fishing industry with an international history. but since these pictures were filmed two years ago the fish factory has stopped operating buying fish from norway is now banned as part of russia's embargo on western fresh food and dairy. that's all this place did so it was particularly vulnerable. supply lines have been severely kiss erupted, and the effect has been felt in shops and markets. >> fish gets more expensive every day. it's gone up 20% in price. >> and rising prices mean that people buy less. >> the suppliers just called, but

the idea is that a rift widening between the united states and europe over the efficacy of the sanctions on russia. but this particular list of sanctions probably won't make a difference at all. >> the peace process in colombia that is been given a past with the president announcing a one- one-month halt in airstrikes on the rebel-held camps. farc announced a cease-fire in december but the president rejected the cease-fire without a deal. they have praised peace talks in cuba. >> to help de-escalate the conflict, i have ordered the defense ministry and armed force to cease bomb batterments over farc camps for one month. >>> venezuela is asking for approval of a bill that would give him more powers. critics have described it as a power grab and worry that it will be used to silence dissent in venezuela. why is president maduro asking for these special powers? >> it's in response to the recent sanctions that the u.s. passed over government officials now madura has cleverly shifted attention from the sanctions that were meant to ban assets and made it something about protecting national sov

into traffic, all of the assaults against monitoring these people were picked up because of the efficacy of this kind of surveillance. >> surveillance in cyber space in particular. >> what it also tells you is that islamic state has become a magnet, of jihadys around the world. of course here if the united states. >> recruiting. >> right. as long as they are perceived as successful and powerful they are going to inspire more such people, not all of whom the fbi and other intelligence agencies are go tock able to stop. so when susan rice says that a group like islamic state is an an existential threat i think that's a very premature judgment on her part. there are thousands of westerners who are traveling or attempting to travel to syria to iraq to be trained and then to return to the west. >> i don't think we can overemphasize enough how the web is contributing to this phenomenon. the web has become a vehicle for recruitment, propaganda i think, and self brain washing by people who spend hours on it listening to these people who then direct them to go and commit these acts. the question

as you probably heard, the vaccine efficacy wasn't great because of the mismatch in the vaccine strain of the predominant strain was h 3 n 2, but there were differences in the h 3 n 2 in the vaccine and what was circulating that made the vaccine not work as well as hoped. when there a predominant h 3 n 2 season this happens every few years. it is a regulary circulating flu strain the elderly tend to be effected more severely. that is in contrast to h 1 n 1 that effects middle aged individuals. last year we had several death. so far this year there one reported death in a individual under 65. we suspect there are deaths in older individuals and those are not reported to us so don't have a count of those. we responded to many outbreaks in long term care facilities, many more than in other seasons that i think speak tooz the tendency of the virus to effect the elderly more severely. we have sort of standard protocols and procedures that we work from to help these long term care facilities control the spled flu that helps to isolate the patient and give antiviral etreatment. that is my las

the administration will have to convince us that you have grasped -- addressed efficaciously. number one, what capabilities are left in place? some we can live with and some to worry about. two, cheating. the inspection regime is all-important. if there are holes and drove the inspection regime i don't see how you will get confidence union agreement -- in an agreement. how to we face the limits, assuming an efficacious agreement and how expeditiously can we impose them? the worry is we might be ok but our allies may not. fourth, a time frame. there is a lot of legitimate concern that it is too fast. that iran can quickly rush to nuclear capability under the reported terms of the agreement. finally the expiration of an agreement. the timeframe that people are concerned about. it is almost an open invitation. thank you madam chairman. madam chairman: it is not my temper tantrum to cut you off, we are out of time. rep. connolly: i know. madam chairman: we will get to the most amount of members we can get to before the witnesses to part. with that the committee stands in recess. >

. >> reporter: the positive efficacy results were a surprise because the study was in the early phases primarily for safety. show side effects including clearing the amyloid plaque from the brain. thought removal of the plaques can weaken blood vessels causing them to leak. >> one of the things they try to do from now on whether lower dose offers same activity with the better safety profile or whether they could change the dosing. at the current dose the side effect looks a little too high so they'll have to figure a way around it. >> reporter: biogen plans to move into a phase three trial skipping over the mid stages of testing. if all goes well analysts say the drug could hit the market as early as 2018 but it's got a lot to prove before then. >> in alzheimer's disease, the chance of success historically has been low. we characterized that the way to think about it we conservatively think about a 30% chance of success, but again, yesterday was fairly encouraging so maybe too conservative. historically, a loy between the early stage testing and then the final phase three results. the

rights and i agree with the assessment there is need for a supplemental to really bring a little more efficacy how the document can affect their lives and there are playgrounds with payment setting and deficient in signage as far as multilingual signage and access and safety. the youth have told us they want increased safety and monitoring and increased police any type of protection to access the parks so i am that you take consideration. they're well thought out supplemental and have additional information to make this bill of rights more of bill of rights and not a bill of talking points. we want to make sure that youth can access these playgrounds safely and they can do so at night and also i would -- some of the work workshops that we did to connect the youth to the park programs make sure that we have more than good will translate on the website and have it in other languages. thank you very much. >> thank you very much. next speaker. >> good afternoon supervisors campos, mar and supervisor christensen i am a district 9 resident. and i am here actually today because i don't think that thi

next step, find balance between safety and efficacy. results of early. doctors are encouraged and important to note the drug was tested in patients at very early stages of alzheimer's disease who might benefit if it reach ares the market. next the company moves the drug quickly into a phase three study jumping over the middle stages of trials. if all goes well analysts say the medicine could reach the market in 2018 or 2019. now that's a lot of excitement about biogin stocks. several analysts raised price targets, going as high as 532 because a successful alzheimer's drug could be huge estimated up to $10 billion in annual revenue. 5 million are expected to have alzheimer's a number that can triple. >> so many of us touched by it. thanks, meg. >>> biotechs on fire. check it out. up 45% in just 2.5 months. this year up 90%, thereabouts, over the past one year. what is driving the biotech boom? where does all of this excitement come from and how much farther might they rise? dominic chu with details. >> that pro shares ultra bio tech as leveled play mp pla

litarilely get the record and the medical information from the physician to use as a pretest, to the efficacy of the program at the end. and then, have all of the systems in place, that we get accredited as an enty, and then, we are establishing a medicare number, which right now, most community programs don't have to be able to build, and so it is, and it is a lot of layers, and i am actually quite amazed at how much, energy is going into this. but the hope is that we will learn something that could be useful in the long run. >> i don't know if that clarifies, but the curriculum is the same and the delivery is different and the reimbursement in the long run will be different if we get those pieces together and get approved. >> the standard model do not have reimbursement. >> no, right now dos is the defender for the healthier living and thanks for linda and dos leadership we have health promotion programs that we never had before but they are it and if we could do something else and get it established by the reimbursement and other entities we will all benefit from that. all right, good luck

extensive product testing is used in terms of efficacy. scrubbing bubbles heavy duty all purpose cleaner has been proven highly effective, killing 99.9% of bacteria as it cleans, including odor-causing bacteria and viruses that cause the common cold and flu. >> we have so many of these things around the house. >> thank you michael. >>> let's turn our attention now to the forecast. oh, i'm sorry, we do have some breaking news in tulsa, oklahoma, where there has been a tornado warning in effect much of the afternoon. you can see there are some tornados, at least two touching down there exploding transformers in their paths. springtime of course a very dangerous time of year in that part of the country. >> this is video taken just moments ago. you can see the transformers blowing up, one after the another, as the twisters move toward the left of the screen. a live look at that storm. tornados also reported in northwestern arkansas. >> no injuries were reported as the storms went through rural parts of the owezark mountains. but this time of y

. >> reporter: the trade group for makers of a seat oh minnow fen said the efficacy is well documented supported by 50 years of scientific study and real-world use. susan fox now wonders if it's a pill that she needs, as she builds strength to win over back pain. anne thompson nbc news new york. >>> we're back in a moment with a big surprise on the map today that kept a lot you total your brand new car. nobody's hurt,but there will still be pain. it comes when your insurance company says they'll only pay three-quarters of what it takes to replace it. what are you supposed to do, drive three-quarters of a car? now if you had liberty mutual new car replacement, you'd get your whole car back. i guess they don't want you driving around on three wheels. smart. with liberty mutual new car replacement, we'll replace the full value of your car. see car insurance in a whole new light. liberty mutual insurance. i'm brian vickers, nascar® driver. i'm kevin nealon comedian. and i'm arnold palmer, professional golfer. know what we have in common? we talked to our doctors about treatment with xarelt

the administration will have to convince us that you have addressed efficaciously. number one, what capabilities are left in place? number of centrifuges, something we can live with, and something to worry about. two, cheating. the inspection regime is all-important. if there are holes and drove the -- in the inspection regime, i don't see how you will get any confidence in an agreement. how to we face the limits, assuming an efficacious agreement and how expeditiously can we impose them? the worry is we might be ok but our allies may not. fourth, a time frame. there is a lot of legitimate concern that it is too fast. that iran can quickly rush to nuclear capability under the reported terms of the agreement. finally the expiration of an agreement. the timeframe that people are concerned about. it is almost an open invitation. thank you madam chairman. madam chairman: it is not my temper tantrum to cut you off, we are out of time. rep. connolly: i know. madam chairman: we will get to recess briefly and then get to the most amount of members we can get to before the w

we know that fda standards and our requirements around safety and efficacy over the years have actually helped to shape how by -- biomedical research and clinical research gets done. this notion of really structuring our investments in research so that we ask the right questions and we don't just published papers as dr. cassidy was saying, we actually make sure that we are leveraging the opportunities in science and technology to get important treatments, preventive strategies, and cures. senator warren: so, you're saying if i understand it, the high standards are important not only for public safety, but also for help shaping the research that's going to give us the treatments that we need. dr. hamburg: absolutely. senator warren: i just want to say i am certain there are changes we could make at the fda to help speed up the approval process and get rid of unnecessary bureaucracy. when science supports change i'm eager to make change. but lowering fda's approval standards will not increase innovation. we could abolish the fda tomorrow and we'd see tons of new products on the market, bu

rights amounts and we need to understand about the chemicals and what that means for safety and efficacy with individuals using them of course, many young children who could be a greater risk with chronic use. said to have more options with sunscreen products we want to work with industry to make sure that they are safe for chronic use spinnaker later due to do whatever you can't. >> thank you senator. calling in order of seniority is favored here at the time of the gavel. >> thank you for holding the hearing. teeeighteen i am sorry to do see you go. i would like to ask to say we cannot walk raise venture capital. and that has to do with regulatory uncertainty. but to create a pathway they can get there only water to drugs of their 22 approved as a result of that legislation in 55 more in the pipeline as i understand it. that has succeeded beyond our wildest dreams and i want to thank you for that. and to talk about the shift of the fda as a result of that designation and how we keep that going after you the if. >> thanks for inviting me to your talk to the biotech community. those types

need to understand about their absorption of these chemicals and what that means for safety and efficacy in the individual using them, including of course many young children who may be at greater risk in terms of chronic use. so we want to move forward. we want to have the american people have more options in terms of sunscreen products and the protection they can afford public want to work with industry to make sure that the ingredients in those sunscreens actually work and that they are safe, especially for chronic use use. >> my time is up but i would like to urge you to do everything you can to expedite the implementation of those approvals. thank you very much. >> thank you senator isakson. i'm calling on senators in order of seniority if they were you at the time of the capital. so that's what -- senator bennet. bennet. >> conlin. thank you very much for holding this hearing, and thank you both for your leadership. dr. hamburg i'm sorry to see to which i know the chairman feels as well. i would like to ask a number of years ago call around a committee came to me and said we can't

taxpayer money and that these funds are being used to maximize efficacy and transparency transparencyrtners on the ground, and how much has gone through multilateral initiatives through u.n. appeals? and i will ask you to respond. it seems that the majority of our assistance from what i have read actually goes to the u.n. and third-party implementing partners. also while it was positive that the u.n. security council passed resolutions 2139 and 2165 calling upon all parties to allow delivery of humanitarian assistance and authorizing the u.n. to carry out relief delivery across these conflict lines, that's really a fanciful notion to think that the assad regime isil al nusra other belligerent actors are actually going to adhere to these resolutions. yet since those resolutions passed, the u.s. has been going into the war zones and the most difficult-to-reach areas of syria. how are these resolutions of full access being enforced? we've seen reports that isil and others have gotten some of this assistance or that implementing partners are a force to go through middlemen to get some of

the efficacy of putting sanctions on russia. >> another battle being lost in eastern ukraine the war on drugs. in donetsk dwindling supplies of methadone means that addicts are not getting proper treatment to get clean. and the share of needles has led to an increase in hiv infection infections. 238,000 people age 15 to 49 are infected and more than 3.5000 people died of a.i.d.s. in ukraine in 2013 according to "world health organization" statistics. john hedron reports from donetsk. >> reporter: it's a nearly daily ritual. every morning but sunday bruce makes the rounds distributing needles, wipes and condoms. since the conflict in eastern ukraine, they are more in need than ever. donetsk is running out of the drugs it uses to get addicts off of heroin. >> they promised to look after us now i've had a fever for the past month. even if we can find t we can't afford it. we have no money. there is a war. >> reporter: ukraine's government has long supplied the drugs for heroin substitution therapy, but in separatist territory that all stopped when the year-long war began. they would use

their lives have a choice of death versus a chance to live with this drug that's already showed efficacya can approve the drug and yet continue to have clinical trials. >> als is a deadly neurological disease without a cure. most patients are given two to five years to live. hospital east of the an cost area river is taking had health care closer to the hospital. united medical center unveiled a mobile health care clinic today. it will make stops in wards 7 and 8. nurses and medical technicians will provide a variety of medical tests including blood pressure and diabetes screenings and hiv and pregnancy tests. we invite you to our nbc washington facebook page for details on where the mobile clinic will be. >>> a news4 i-team investigation getting results. we'll tell you about the change that could be coming for anybody looking to buy a home in maryland. >> reporter: public outcry over which restroom a young transgender student uses. i'm >>> i'm chris lawrence at the live desk. tonight people are sharing some very warm memories in northern virginia after we learn that a mother and daughte

not only is it efficacious on top of statins, jim, but in addition to that it was very safe and wellolerated and of course that's vitally important for patients who are taking a medicine like this or could take a medicine like this for the rest of their lives. >> let's put myself in the shoes of the fda. the regeneron drug, you don't have to go to the doctor and you can self-inject it and it works. and so far the health profile is pretty good. why would i say to esperion i have to fast track you when i have something and you guys can take your time. do it right. aren't you afraid that the fda isn't going to do me too with you and rush this? >> i don't think we're looking to rush anything. we are very seasoned drug developers as a team, at esperion. and we have been developing this drug in a very forthright fashion, carefully, but also very quickly. and so we're not looking for the fda to necessarily rush this. we are looking to move it forward, and we had been working cooperatively with fda to do that. what we like to say is that we hold the radical belief that patients will prefer a

hullabaloo will impact the deal whether or not we strike a deal with iran, but i do think that the efficacys up for grabs signed or not. sanctions are still threaten -- the irof sanctionses training to topple the entire process. near large part depending upon verification measures which is not effective with this rogue regime so a lot of different things at play. but i don't think this will take the negotiations down. >> i hope not. gillian turner is live from washington. thank you. >> thank you. >> white collar criminal could some get same treatment as registered sex offender ifs they live in utah. the -- governor is expected to sign into law the nation's first white collar crime registry. if this does become the law, people in utah could go online to look up which of their neighbors committed a white collar crime. according to the feds estimated losses from white collar time totals $1.7 trillion. adam shapiro is in our newsroom. how will this work? >> it's going be like a sex offender registry. they have to have a picture of the person, but the question is why is utah the first to do this

this class of drug which travel along with the very large, as you mention before doubling of the efficacynal. overall, though the benefit-risk equation is extremely favorable. we also saw a much lower rate of perative really neuropathy damage to the nerves and hands and feet which is again, a really important issue for in class of drug. >> all right. dr. harper thank you very much. congratulations. we appreciate you being with us. >>> big critic of russia's putin gunned down and big bond news out of austria. >> michelle carusa cabrera taking us around the world in 90 seconds. >> that's coming up. we're also going to tell you about the new hilton in havana when "power lunch" continues after this. it's more than the cloud. it's security - and flexibility. it's where great ideas and vital data are stored. with centurylink you get advanced technology solutions from a trusted it partner. including cloud and hosting services - all backed by an industry leading broadband network and people committed to helping you grow your business. you get a company that's more than just the sum of it's parts.

stage study just looking for the safety of the drug and they shocked everyone with showing signs of efficacymyloid plaque build-ups and the cognition. people losing memory, not thinking as clearly, they showed a statistically significant benefit stemming those cognitive declines. now what they'll release on friday morning are the full results from that study. what analysts look to see is how significant were those results, are they pointing in the right direction, is this real? did they see such a great effect in such a small study? and they said based on that data, they'll move directly into phase three. so it's looking really good. there's a lot of expectations here. analysts say if the data are really bad, really miss expectations, the stock could drop 20%. if they're really, really good, it could go up 15%. this is a $100 billion market cap company, so these are huge moves. >> are the results binary, anything they could come out with in the middle? >> there definitely could be in the middle. often, that's what we see. this happened with another program called anti-lin goe. kind of a mixe

the thing you have to remember this study was done for safety and efficacy.eed more study with tins of thousand of patients. >> that brings up the question i was going to ask. not that many people were tested for this and i wonder about the results. we know number of heart attacks and strokes that occur every year, 1.5 million people. so lots of folks could get helped ultimately by this. >> exactly. what we think of, you know, i just returned from the american college of cardiology meeting where this was presented in san diego. this gives us another you know, arrow in our quiver, another way to fight heart disease. i think when these studies are done. i think we'll have data by 2017, could be a huge extra way to treat patients with really bad cholesterol problems. gerri: do you know what side-effects are? >> what we've seen in this preliminary studyies are minimal side-effects. it showed a little bit of memory loss. that can be a problem. a lot of patients in this demographic are older and may suffer from dementia and memory loss. we want to be careful about

apparent turn around what is behind this security turn around, what do you make of the speed and efficacyonse to boko haram in the northeast of nigeria? >> i it can be argued a combination of issues and seen improved resources allocates to the nigeria army. we have seen also the coordination of multi national forces nigeria's neighbors obviously providing assistance in fighting boko haram and i think this is really aided and boko haram was seemingly operating across the lake chad region with relative impunity and for nigeria the operations were limited to borders and boko haram was obviously operating in neighboring countries, nigeria did not have mandate to launch in these regions and coordination of resources and operations at this stage is possibly quite focal to their significant gains we have seen being made against the extremist sector. >> so if the government and its allied forces are establishing significant gains in this particularly blighted region what is happening to the boko haram fighters those who are not killed or captured what is happening to them? >> it's very difficult

regulatory process of getting drugs approved quickly that were experimental drugs that showed some efficacy change in paradigm that had not been experienced before. c-span: we will come back to some of this, but we have seen a lot of you over the years. i want to talk about your background and life. when did you make a decision why you would be available to the media? there are 27 institutes at the national institutes of health and i could name maybe one or two others. you are always available to answer questions. why? >> guest: it became clear to me that particularly in the discipline i was dealing with, emerging infectious diseases that would generate a lot of concern on the part of the public hiv-aids, pandemic flu ebola, most recently now with the ebola crisis it became clear that the public needed to be educated to understand just what these issues meant to them personally and to the nation and the world. i was perplexed by seeing scientists who shunned away from trying to explain things in plain english in a way people could understand. there was a culture back then that scientists di

and that study after study shows the risk and benefit of vaccines and the efficacy of vaccines to protect what you just said is interesting. is it the internet and media that has allowed this to persist? >> i would say in the words of barbara lowe fisher who heads up the vaccine information center and we interviewed her, the internet is a force, it empowers people to access information and to spread information. it can't be just that the internet itself is to blame for public health's challenge with all of this. public health also needs to do their job at communicating and listening and then helping their message come across clearly. >> i hear that. and that is fine up to a point. and there is misinformation on the internet cutting against public health. i think your piece is fair-minded in looking at that and that is one of the problems a lot of us are concerned about. kate mcmahon, thank you for your time. >>> and the thrill of victory and the agony of defeat. there is a basketball game going on. >> and utah won. >> it is something we'll talk about next with jordan. across america peopl

in some cases that's the efficacy of some of these drugs where the patient would die in three months,ow they're going to die in a year. i'm not sure what society is going to do there. but the good news is, the industry is using their human capital and they're making a lot of innovations and, you know, they're generating a lot of value at this time. we do have to watch the payer situation. >> okay. >> sit tight. we will take a quick break and come back and talk apple, more stocks as well with will danoff. why is apple his second biggest holding right now and how he plays it from here. why he's investing in the popular private companies. carl icahn boosting his stake in one of the worst performing energy names. how should you play it? that and much more straight ahead. ♪ if i could maybe i would give you my word ♪ female announcer: sunday's your last chance to save big during sleep train's triple choice sale. for a limited time, you can choose up to 48 months interest-free financing on a huge selection of tempur-pedic models. or choose to save hundreds on simmons beautyrest mattress set

>>james: fire fighters are investigating a massive fire and were housed in chicago's south side efficacy by this picture how big it is in the background of fire market last night in a two-story warehouse as of this most recent update the fire had reached three months and has met teams have been called to the same so far there's been reports of injuries that caused an investigation. a san diego man is asking for justice after the call was shot and killed his service dog in and assisted the service dog was helped him cope with depression and anxiety the department sought an early sunday morning incident caught on camera officers who arrived at the home in pacific beach responding to call in the area the dog was out of the hall of the time and is a worm the opposition reached out to the dog not trying to look threatening. you see video of the dog attacking the officer he had a turn in now will not talk about what he saw instead his calling on state leaders to require officers to undergo training related to dog. the head of the six servers oppression of carter white house barricade are great