part of that is the framingham study which we funded in massachusetts which taught us what the risk factorst you could interfere with. we did not know how important hypertension was and how critical it was to treat it. part of this is also drugs, statins, the most commonly prescribed drugs these days. why do we know about them? it is because of basic science research done 30 years ago by nobel laureates brown and goldstein, figuring out there was a critical pathway that controls cholesterol. and that you could interfere with that with the development of a particular drug. david: when humans emerged from caves 200,000 years ago or so, they were homo sapiens, the average life expectancy was 20. more or less. today, it is more or less in the developed worlds, maybe around 80, so we have increased our life expectancy by four times. how much longer can people keep increasing their longevity? dr. collins: so much of that happened in the last hundred years. if you look around 1900, average lifespan in the united states was late 40's, so we have dramatically extended that. is human life extendable