he and his partners launched genentech in 1976 with nothing more than a checkbook and an idea. >> thehat didn't exist in nature -- in particular, human insulin. >> genentech's success led to new ways of treating everything from diabetes to dwarfism, and to getting rich. kleiner perkins' initial investment of $250,000 soared 800-fold to $200 million. >> that's what venture capitalists are created to do, and you can blame converting the orchards of silicon valley into parking lots partly on me and partly on genentech, because we proved that this kind of high-risk, high-tech venture capital could be an enormous home run, and everybody wanted to get in on it, including lots of entrepreneurs, and that's what got this whole silicon valley engine rolling, in my opinion. >> and it took somebody like perkins, with a background in science, to figure it out. he got an engineering degree from m.i.t. and an mba from harvard business school, and yet, he says, only two out of about every 10 of his projects resulted in a home run. when you think about putting as much money as you have to into these p

provide to genentech, so forth. the last few years it feels like the street got flooded. so, i think it had a huge impact on our city. i said to myself, how did this happen without any public discussion first? usually when there is a pilot project, we close down mid-market for one block. let's study this for awhile and see [speaker not understood]. now all the buses are there. now i feel like the pilot study is being proposed let's have 200 stops and do the pilot study. i'm worried that this is going to rubber stamp it and this is going to be a done deal. i'd like to point out and confirm what the other people said, i think there needs to be a lot of environmental impact. carbon footprint, how much carbon footprint is added by people who are being displaced, people with high incomes, what kind of consumption pattern do they have, what kind of a carbon footprint does that bring in? it's a complicated study to say all these people, all the less cars for the buses i think very simplistic and i would also propose furthe

genentech started shuttling employees in 2006. >> the goal of our prom to encourage students to stop driving to work alone in their car. and the give information on the improvement needed to make this transportation work for everyone. >>> a state of emergency in effect across several mid west states tonight. because of a blast of bitterly cold air produced by a weather phenomenon known as polar vortex. temperatures dipped well below 0. wind chills reached 50 below after more than ten inches of snow fell. jet blue grounded flights at three airports as well as boston logan until 7:00 tomorrow morning. and chick airport alone. well, all told 3400 flights have been cancel add cross the count tray cording to flight ware.com. another 3800 have been delayed. capseled flights mean stranded travellers. they booked 40 rooms at the holiday inn. the travellers aren't too pleased but are trying to make the best of it. >> i spent time on hold and on phones trying to reschedule things and tell people we're not there. you put your life on hold. could be in worse places but it's we're trying to make

you have amgen there and genentech and a fire marshal says a cleaning solvent used to sterilize equipmentay have caused a chemical reaction that led to this explosion. >> the building has been evacuated. no word yet if there are any injuries. a crew is arriving on the scene and we'll bring you the latest in our 6:00 newscast. meantime, thanks so much for joining us, and we hope to see you then. >> thanks for joining us. >>> on our broadcast tonight, in a jam, a big problem for a man with big ambitions. tonight, how a traffic nightmare on the world's busiest bridge has gone into a full blown scandal with the power to damage chris christie's political future. >>> polar opposite. deep freeze continuing to bite hard across the country, other parts of the world are seeing record heat. so where does the discussion about global warming stand right now. >>> back lash, after dennis rodman goes off the rail and singing happy birthday to the dictator of north korea. >>> and ann curry, in what is one of the most dangerous places on earth. "nightly news" begins now. >>> from nbc news headquarters this

35,000 people commute on these private shuttles every day including google, apple, facebook and genentech. >> we don't want to cause delays in muni. >> i'm concerned about the gentrification that is going on. and it's because of google or twitter. >> each company will pay around $100,000 to recoup the city's costs for the next 18 months. >>> back to workweek, back to school week and the weather for us is cooperating more than on the east coast. >> look at this. miami, 55, san jose, 51. california and florida the number one warmest locations tomorrow morning. and, yes, that is minus 9 in chicago. the thing that is helping us to stay warmer is the fact that we have cloud cover overhead in san jose and san francisco. we had showers off to the north. do expect the clouds to stick around tomorrow morning. right now the temperatures in the 50s. but we have a few holes in the clouds. we have radiational cooling happening. some of the heating escaping into the atmosphere. in san francisco we do have fog up against the immediate coastline. but a clear shot right now downtown and relatively calm wi

the boston consulting group out of san francisco came in third t genentech, sales force and intuit cracked the top 10. to check the complete list head to kpix.com. >>> it is 4:51. sacramento kings are trying something new. a new way fans will be able to buy tickets and their merchandise. >> plus, loud enough to break a world record, enough force as a small earthquake. coming up, the extreme noise the 49ers will have to face at seahawks stadium this sunday. ,,,,,, ,,,,,,,,,, in march, fans will be ableo buy tickets and merchandise using "bitcoin". that currency gained notoriety wn the website "silk road" was busted. it offered illic >>> in march fans will be able to buy tickets and merchandise using bitcoin. that currency gained notoriety when the website silk road was busted. it offered illicit services and the only payment was bitcoin. but the kings see this as a move to recognize the tech savvy fan base. >> they will scan a qr code into their phone with one click, there will be a bit coin payment from the bitcoin wallet to the team and it's simple. >> one of the benefits of bitcoin is th

. >> five are right here in the bay area, google at number one, genentech number six. >> san franciscoles force came in 7th. >> abc7 news joins us live to see why it ranked so high. >> everyone wants to know a secret form lachlt we think we found out why intuit is a great place to work. people say culture is a s.like a small start up. people work in cube cells ask can take breaks to play games or take an exercise, employees encouraged to come up with ways to make the software better for customers. jessica summers created this emotion garden. >> i feel intuit fosters my passion i don't know if i can go to another company and say let me focus on efrp pathy. they'd be like who are you? no. >> intuit made it on the list for 13 years, but this yeeshg it's number eight. the ceo says he operates the company as an inverted pyramid. >> people decide if you're a leader. we have 8,000 leaders, called employees. >> employers tell us that is true. and innovation award paid one employee $1 million, half cash, half stock. there are tl is good food, cupcakes on the menu today to celebrate the list aga

the others are genentech. sales force.com, intuit and dpr construction. fortune magazine released the survey. >>> dozens of police family gathered to celebrate today at city hall. >> everyone being promoted today has been selected due to their integrity, work ethic and dedication to public service. >> police chief sean went addressed those there and said everyone in opd is working toward innovative crime fighting and community collaborations. these are just some of the men and women promoted today. >>> cooling down for your weekend. how much temperatures will trend down where you live. >> doing your part to conserve water. how everything from a high tech gadget to a plastic bag can help you save. >> i save about 100-gallons a day. >>> waking up to a fast moving fire. >> somebody called fire, fire from the street. >> what we learned about the quick thinking that helped save lives. to those who've been denied ewelcome to covered california. now, you can no longer be denied coverage because of a pre-existing condition. enroll today at coveredca.com. >>> feel

the others are genentech. sales force.com, intuit and dpr construction. fortune magazine released the survey. >>> dozens of police family gathered to celebrate today at city hall. >> everyone being promoted today has been selected due to their integrity, work ethic and dedication to public service. >> police chief sean went addressed those there and said everyone in opd is working toward innovative crime fighting and community collaborations. these are just some of the men and women promoted today. >>> cooling down for your weekend. how much temperatures will trend down where you live. >> doing your part to conserve water. how everything from a high tech gadget to a plastic bag can help you save. >> i save the recent increase in cafeteria prices is not cool. when you vote for flo, we'll have discounts. ice-cream discounts. multi-cookie discounts. pizza loyalty discounts! [ kids chanting "flo!" ] i also have some great ideas on car insurance. [ silence ] finding you discounts since back in the day. call or click today. i like her. >>> feel the love baby. f

partnered with google and genentech running shuttle buses. this plan would allow the shuttle buses to access 200 of those stops. that would bring in about $1.6 million during the 18 month pilot. shuttles would be required to yield to muni buses and avoid steep and narrow streets. the issue of affordable housing, supervisor scott weiner says it is a problem but tech workers are not to blame. >> we need to work really hard to address our housing prices. tech workers did not cause our housing crisis. >> reporter: the mta board is expected to meet on january 1st to consider this proposal and if it passes they're expected to propose a new plan for the spring. >>> about 1,000 customers are without water after a break in an 8-inch main. the break was reported about 5:30 this evening off monterey boulevard at industry. a spokesperson for the public utility's department say the pipes date back to 1929 and are vulnerable to breaks at this time of year. when water gets very cold. crews are working to restore the water service but no estimate at this poi

partnered with google and genentech running shuttle buses.his plan would allow the shuttle buses to access 200 of those stops. that would bring in about $1.6 million during the 18 month pilot. shuttles would be required to yield to muni buses and avoid steep and narrow streets. the issue of affordable housing, supervisor scott weiner says it is a problem but tech workers are not to blame. >> we need to work really hard to address our housing prices. tech workers did not cause our housing crisis. >> reporter: the mta board is expected to meet on january 1st to consider this proposal and if it passes they're expected to propose a new plan for the spring. >>> about 1,000 customers are without water after a break in an 8-inch main. the break was reported about 5:30 this evening off monterey boulevard at industry. a spokesperson for the public utility's department say the pipes date back to 1929 and are vulnerable to breaks at this time of year. when water gets very cold. crews are working to restore the water service but no estimate at this point

study in monotherapy or by itself, a study in combination with the $7 billion drug by roche and genentechncer and gastric cancer. we're trying to expand and broaden the utility of this agent in a number of novel areas. >> okay, now, piper jaffray has a buy on your stock was saying that one of the phase three present trials has gone slower than expected and we anticipate data mid 2017, a year later, should we take therefore there are setbacks in the trials? >> no, like anything doing research you have to get set up. we're in 130 hospitals in 15 countries spanning from north america to western europe, eastern europe and israel, and it takes time to get those set up and we're now in a pace and progression where we'll have it fully enrolled by mid-year, and then interim analysis where we have about a year's time. then the full answer if you will in the end of phase three. in the meantime, we're continuing to work on our combination study and then get this 90 patient phase two in gastric cancer off the board. >> doctor, there has been some controversy, i know in seeking -- there are some no na

, genentech pick up and drop off workers every day.'t pay for using those muni bus stops. transit officials are considering charging companies a dollar a kay per -- a day per stop and also limit the number of buses, the bus stops the companies can use. transit leaders can six months to work pout all of the details. there will be another vote taken in june. if that's approved, the 18- month trial would start in july. >>> 8:40. we just got a gloomy prediction about facebook. what researchers say might happen to the social media giant in just a few years. >> reporter: we're live in screal where we have -- vallejo where we have new details about an early-morning homicide this morning. we'll bring you the latest coming up after the break. >>> good morning. we still have traffic that will be tough in the bay. northbound 280 is slowing down. we'll tell you what the drive times are. >>> wall-to-wall sunshine. temperatures are rebound in record-setting trt. it will be -- territory. ♪ at kaiser permanente we've reduced serious heart attacks by 6