it doesn't matter that worldwide three hundred fifty million people are affected by genetic disorders closed by faulty d.n.a. these genetic defects can lead to a variety of conditions like cystic fibrosis which leads to conic and also cite a long sections and at the moment the system and here i am dr elizabeth healy in the u.k. to see how groundbreaking developments in gene therapy could one day transform the lives of people living with genetic disorders. that may l.l.s. but not marry bond on a is sixteen years old and was diagnosed with cystic fibrosis at the age of one. america tell me from your perspective what is your day like living with cystic fibrosis. arum when i asked her i guess op take my interview arises off eyes. and then harass again my x. tears. and i asked you i know you guys are failing. and they're nasty to my physio if. i do spiral a.j. and i'm going to go out and just plain for their help in me. and then off of our ass to do a nothing up the lies well. there are still more positives. and then yeah i will need space for city of about how to learn. and an hour a nigh

and don't even say no, i mean the lighter side ofmolecular genetics . i promise you, it's not a good way to proceed. there are a couple of better ways. and one of them is to say well, look at these 2 images andi'm going to show you a couple of images . that's essentially the 1st evolutionary tree of life. the tree of life is of course this old metaphor, an old phrase that goes back to the book of revelations, the tree of life symbolizing christ and his blessings, the fruit and believes that rep represent the blessings of christ upon the world, the tree of life but in the middle 19th century, the tree of life suddenly turned into an evolutionary metaphor. when charles darwin gets this little stick figure tree into one of his secret transmutation notebooks in 1837 he was just a couple years back , the beagle voyage around the world and he was brainstorming his way to a theory of evolution. except he didn't call it evolution, he called transmutation and he had the idea that he became convinced all life had originated from a single or very few points of ori

constructs and change genetic expression they can be used as weapons what's also interesting is that even if it were not being used as weapons it's extremely dangerous enormously dangerous to even release these at this point they're already releasing them in greenhouses and if there was an earthquake or some kind of problem where they released we have no idea how they might actually reproduce and propagate in the gene pool changing the nature of our ecology perhaps forever. and don't all trumps efforts to punish russia for its alleged election meddling could end up hitting american consumers in the pocket. many many ports are about to get more expensive since the u.s. treasuries imposition of sanctions on the moscow based alimony and giant roussel in april fears of a global shortage up and growing. pressures on the price washington officials have repeatedly pushed back the deadline for compliance with the restrictions at american firms originally had to stop doing business with the resolved by the end of this month but that was extended to mid november to a lot more time for talks re

very precisely and delivers one or more or a dozen different genetic reprogramming instructions that regenerate that tissue organ and so that goes well beyond just single genetic diseases and then you know therapy isn't really extends into regenerative medicine and aging as a disease as well andrea had never met anybody and hopefully i will in the future but i've never met anybody who has a delivery guided nucleus thank you so much for the forward thinking and what you're doing that's andrea watson the founder and c.e.o. of like gandel thanks andrea. that's it for this time thank you for being on board we sure had fun we're going to be doing more of it in the coming days but always catch boom bust on direct t.v. channel three twenty one dish network channel two eighty or streaming twenty four seven on pluto t.v. that's the free t.v. app channel one thirty two or you can catch us always at youtube dot com slash boom bust r.t. so long for now. kind of financial fun today with the money laundering first to visit this industry different. this is a good start well we have our three banks

constructs and change genetic expression they can be used as weapons what's also interesting is that even if it were not being used as weapons it's extremely dangerous enormously dangerous to even release these at this point they're already releasing them in greenhouses and if there was an earthquake or some kind of problem where they released we have no idea how they might actually reproduce and propagate in the gene pool changing the nature of our ecology perhaps forever. let's go up to three thoughts and join us again at the top of the hour for the latest global news updates. what politicians do you can. put themselves on the line to get accepted or rejected . so when you want to be president when she. wanted. to go on to be pros this is what the full story of the morning can't be good. i'm interested always in the waters in the house. when city hall. this is crude oil. so they need to actually physically pulled it out of the ground he would have well well well well well. there's a lot of money with the oil and with that comes. a lot of a lot of people from all over the country. i

constructs and change genetic expression they can be used as weapons what's also interesting is that even if it were not being used as weapons it's extremely dangerous enormously dangerous to even release these at this point they're already releasing them in greenhouses and if there was an earthquake or some kind of problem where they released we have no idea how they might actually reproduce and propagate in the gene pool changing the nature of our ecology perhaps forever. ok let's go back to our top story now thousands are protesting across france against him on old reforms in paris clashes have erupted between demonstrators and police these are live pictures from the french capital we're showing you now where students labor unions and pensioners have now gathered quite a large a row. police presence there. appears to be some sort of smoke falling through the street gas canister or tear gas perhaps and we are staying cross the story shot at the correspondent who's on the ground at some of those protests as well she will regress live updates a little bit later from charlotte in the

to stick fibrosis is as you know a genetically inherited disease parents who pass those copies on to their child and they have cystic fibrosis during the first year of life most babies will experience and lung problems and those relate to the buildup of sticky mucus within the airways and that sticky mucus attracts bacterial infections and the bacteria infections become chronic and they eventually cause quite significant lung scarring in the u.k. around ten thousand people with cystic fibrosis at the moment on a registry about one in twenty two of us is a carrier of the mutated gene most of us won't realise and about one in two thousand babies are born with cystic fibrosis the genetic nature of this and other conditions mean that treatment has focused on managing the symptoms as best as possible but a new and experimental technique called gene therapy replace the faulty gene with a functioning one this is the largest and the longest duration gene therapy trial using a liquid formulation for cystic fibrosis that has ever happened in. two hundred sixteen patients completed the protocol

and genetic testing is down to $250. i think the most important part of it is genetic counseling. and there aren't that many genetic counselors. you want to go to an experienced center where they can council you if you do have the gene. >> it might take your question in a slightly different direction. i agree with everything you said. but one area where i think we should encourage people to ask for genetic testing is when they are diagnosed with cancer seeking out a mutation testing for their cancer wherever possible. and i think in addition to broad genetic screening, i think that's an important question. one of the things we should encourage patients, particularly those enrolled on clinical trials or those not enrolled on clinical trials to find ways to access sequencing of their tumors to increase the data set necessary to drive innovation and if you have a family member that's been diagnosed, you should consider asking your physician about the utility of the sequencing your tumor or doing other genetic testing because one of things we're learning over time is cancers are are r

constructs and change genetic expression they can be used as weapons what's also interesting is that even if it were not being used as weapons it's extremely dangerous enormously dangerous to even release these at this point they're already releasing them in greenhouses and if there was an earthquake or some kind of problem where they released we have no idea how they might actually reproduce and propagate in the gene pool changing the nature of our ecology perhaps forever. and discovering oil should be a chance to celebrate an economic boost on the creation of thousands of local jobs things of town sour though in the u.s. state of north dakota the new oil wealth there is being linked with drug abuse prostitution and domestic violence this wednesday on our table take an in-depth look at the story. it was very agricultural community it was mostly just cattle and farmland. you had this small little town of watford and then all of a sudden the whole of these people move in. this is. so they need to actually physically can't get out of the ground. so i think that made it more to cut a st

it's an 8-year-old patient with a genetic disease. without treatment, he could hardly stand unaided. i'll click on the other one on the football field. so that was seven weeks later. >> and you're convinced this isn't random. >> he was on and off. colleagues who saw him couldn't believe how much he improved. he did not support our football team, but nevertheless, he improved very much. go to the next, please. not the video. to the next slide, please. click on the animal on the left and the right. so these are the complementary studies. the left one please, also. this animal gets the same drug and the same dosage per kilogram. you see the major difference. if you will measure the time it takes until the animal reaches the bottom, the nontreated will be faster before it falls down. we just have to have a global impression. >> so these studies are being done in germany? >> this is done in collaboration with oxford. >> but my question is, if you want to these studies, what's the odds the fda is going to look at these studies you've alread

i'd say, "well, i'm a professional genetic genealogist." and people would just look at me blankly, like, "what is that?" >> kroft: people are just beginning to find out. cece moore is now the lead genealogist for parabon nanolabs, a small d.n.a. technology company in reston, virginia that is leading the way in genetic genealogy. >> the sheriff's office arrested michael f.a. henslick, without incident. >> kroft: the day we visited her, police halfway across the country announced that they had made an arrest on a nine-year- old murder case that she'd been working on. >> moore: this was just this morning, a couple hours ago. >> kroft: where abouts? >> moore: in champaign, illinois. this is the holly cassano murder. she had been stabbed repeatedly, i think about 60 times, in her mobile home. and she was a young, single mother. >> kroft: moore has played a pivotal role in identifying suspects in 13 of the 14 cases that have arisen since the golden state killer opened the floodgates six months ago. >> moore: i'm looking at the people who share th

so we can take a stool sample and collect the genetic material from it. the results show that the diversity of gut bacteria is different in slim and overweight people. it's preferable to have a lot of different strains of bacteria. piece of the study showed that a quarter of people have produced biodiversity in the gut that it's. not correlates with very desirable by like an increased risk of inflammation in the pool. sterility is vital in hospitals but excessive cleaning and fear of germs have become part of everyday life which is bad news for us and our bacteria. is a gastroenterologist at berlin's shyte a hospital. every day she sees increasingly young patients who suffer from chronic and to writers and inflammation of the intestine the conses swelling and bleeding in patients with enteritis the microbiota is also thrown off balance leading to a decrease in good bacteria and an increase in bad bacteria plus bacterial diversity is lower than in healthy people. it's not yet known of these dips and good bacteria cause diseases but one thing is clear in th

the most important part is genetic counseling and there aren't that many genetic counselors. you want to experience a center where they can counsel you if they have the gene. >> i might take your question in a different direction. one area i think we should encourage people to ask for genetic testing is when they are diagnosed with cancer seeking up mutation testing wherever possible. one of the things as we should find ways to access increasing the data set necessary to drive innovation. if you have a family member that is diagnosed you should ask about the facility of doing other genetic testing. cancers are really distinct from person-to-person and the way that we innovate is to learn through those large data sets. populations in crete-- i want to put in a plug for tumor sequencing and other genetic tumors. >> i think there's another different sequencing you are talking about. that's going to be genome sequencing were patients with cancer, expression of different proteins is important because we can determine therapies. now we are moving more and more toward patient specif

it's quite a feat of genetic engineering, but what's the point?ating and comprehensive study that told us a little bit new about the special imprinted genes. the team, the chinese team, made some progress over what was known before. in 2004, a japanese group also developed offspring from the paternal parents, but the emphasis of this process was much lower and the mice were not normal. the new study shows plenty of the offspring could be obtained. they grew up well and they were able to have offspring on their own. however, there's still a lot more we don't know about these mice. you cannot ask a mouse she has a headache. i believe a lot of follow—up studies are necessary to investigate these mice and to be really sure that they are normal and healthy. there's been some talk about it breaking the rules of reproduction, but i guess these things called rules are maybe for humans, that you need a dad and a mum, but not so in the rest of nature at all? well, if we're talking about the mothers, —— mammals, maternal and paternal parts are needed and the

a precise diagnosis has to be made nowadays by genetic testing. the disease should have a high impact in terms of signs symptoms and also functioning and quality of life not only of the patient but also the caregivers. and there is a high medical need and no other treatment available yet. when it comes to the drugs, it should have a good safety profile. the efficacy should be shown as opposed to a placebo effect. and finally, the design the study and the outcome measures. they should always be clinically meaningful in terms of functioning and quality of life. imagine a patient is now able to walk or use the hands properly, take the tablets, take the meals by him or herself, as you will see in one of the videos. this is a major improvement. what would be the impact of adjusting the approval measures for pharmaceutical companies and research? we live in a world of commerce, investment, making money for pharmaceutical companies. this is important not only for the shareholders but also for patients. how is this related to the topic? in the approval of

which is why it is more important than ever to preserve a mass of genetic diversity. and work. out if this diversity will help us find solutions will the future. you want to hear secada we are trying to preserve this legacy and i'll see. you car there is no endeavoring to rebuild this legacy in lebanon and morocco the exiled agronomists were given fields and facilities here. the buildings aren't as large as those back home but continuing their work in syria had become impossible. in the fighting had devastated a car and its valuable collection of seats in aleppo. between two thousand and eleven in two thousand and fifteen as the conflicts drew perilously. close the card as agronomists launched a daring project to save their seats. while fighting raged around them the scientists said about having their most valuable specimens taken out of the country . when the war forced us to give up a center in tel aviv i first wanted to save my. collection was even more important to barry who didn't. know we did everything we could to duplicate the seeds and send them a brawl it was extremel

. >> reporter: her name is cece moore and she is now a genetic genealogist.. you may have seen her on this show. >> you may be my father. >> reporter: helping foundlings, babies abandoned at birth, and adoptees find their biological parents. making family connections never thought possible. >> i love you. >> reporter: moore got hooked on genealogy when she researched her own family years ago. and although she didn't break the golden state killer case, her groundbreaking methods helped. she has received international recognition for her pioneering techniques. >> this was a different way of applying the science. it's not taught in schools, there's no degree you can get in genetic genealogy. there's no certification, you had to think outside the box and perhaps you needed some creativity, and i came from a creative background. >> reporter: moore has always known she could use her genetic genealogy skills to catch criminals, but she was reluctant. >> there were some bioethicists and legal experts that i expected to be against this and i was very surprised after t

its primary instrument is seeds of genetic heritage that almost disappeared amidst the destruction in syria. no nominees are deemed a month that they count that he lives in the so-called fertile crescent. this area's been farmed for more than ten thousand. a month extension human response is a wild. piece and lentulus. how a name of a one. off but here minute i'm sure you were they say it's be used by the first farm and can't see it in ways that are you know over the centuries the farm is then to cultivate the seeds inventing agriculture in the process ha see them as it was. a unit in my current climate change makes it impossible to predict tomorrow's challenges. which is why it is more important than ever to preserve a mass of genetic diversity as an equal and an award. but not if this type of a city will help us find solutions will the future. you want to hear secada we are trying to preserve this legacy and i'll see the. card is no endeavoring to rebuild this legacy in lebanon and morocco the exiled agronomists were given fields and facilities here. the buildings aren't as large as

been awarded for new drugs to treat rare pediatric diseases, for diseases ranging from cancer to a genetic cause of blindness, to the first marijuana derived can a bit i do drug to treat two forms of effortlessly -- to rare forms of epilepsy. the fda has a number of other tools at its disposal to aid in the development and approval of drugs for rare diseases, several of which have been enacted in the last two years. the same law that extended and strengthened the pediatric priority review voucher program in the 21st century cures act, also required the fda to develop guidance on how to use adaptive trial designs and bayesian method for clinical trials. the fda published the draft method last month and the same day the fda also published guidance on this so-called master protocols which can allow a single clinical trial to evaluate multiple drug candidates, multiple disease types and more than one patient population under the same clinical trial structure, potentially reducing the time and cost of generating the necessary data for approvals, or approval. one of the common points we hear fro

. >>> up next tonight, genetic testing for women at risk of breast cancer. we'll show you how many women are detecting the disease early and stopping it before it's spread. >> the l.a. dodgers just one win away from the world series. mark has more in sports coming up. >> and high-tech garbage bins in san francisco today. the special features officials hope will cut down on vandalism and keep trash from overflowing. overflowing. >>> october is breast cancer awareness month and tonight we are looking at the importance of genetic testing as a way of detecting the disease before it spreads. women with certain gene mutations have a higher risk and the testing provides a lifeline. >> i have friends with breast cancer. >> reporter: every year since she turned 40 she got a regular mammogram. she says that comes extra anxiety. >> you're on a roller coaster. we're all kind of waiting for that axe to fall maybe. >> reporter: she decided to participate in the wisdom study to find out her exact risk for breast cancer based on her genetics. >> a friend told me about it. b

one of the amazing things about rice is that we have extraordinary genetic adversity that we can usee concern about rice farming is that much like beef and cattle farming, it also produces a lot of methane. correct, it does produce methane, from the flooded rice crop. so we are working on new techniques, new production systems that allow the crop to be just as productive, production systems that allow the crop to bejust as productive, but to produce less methane at the same time. and we know it climate change is not just time. and we know it climate change is notjust affecting the production of rice, it is also impacting the nutrition value of rice. how so? so as climate change and carbon dioxide levels increase, plants are better at producing more sugar, more start, but that means that they might contain less protein and less other essential nutrients, so part of the challenge is to breed varieties of rice that maintain their nutritional quality. now, the uk and eu said key issues remain unresolved following unscheduled brexit talks in brussels. brexit secretary dominic raab and un

it doesn't matter that worldwide three hundred fifty million people are affected by genetic disorders closed by faulty d.n.a. these genetic defects can lead to a variety of conditions like cystic fibrosis which leads to a conic on also sight along sections and at the moment the system and here i am dr elizabeth healy in the u.k. to see how groundbreaking developments in gene therapy could one day transform the lives of people living with genetic disorders. that may l.l.s. but not marry bond on a is sixteen years old and was diagnosed with cystic fibrosis at the age of one. america tell me from your perspective what is your day like living with cystic fibrosis. aaron when i asked so i guess i ought to take my interview arises off eyes. and then you're sitting in my inbox tears. and i asked you i know now you guys are failing. and they're nasty my physio and. i do spiral a.j. and i'm going to go out and cheerfully and they're helping me. and then off about asked to do another nebulizer. there are still more passes. and then i will need space also you have all now so learn. that our nigh

gives scientists the power to alter disease causing mutations in dna but also to understand the genetics of disease in a way we haven't been able to in the past. >> and now what could it be used for in theory in humans? >> well,humans, amazingly, it's already going into clinical trials for cancer patients where it's being used to target particular tumors. in the not too distant future i think we'll see clinical trials for things like sickle cell anemia, muscular dystrophy, well-known diseases that have a single genetic basis that could be corrected. >> you're about to go to the huntington's conference. from this interview. tell me what people who have the disease say to you about what you're doing. >> i met a man in my office in berkeley who came to see me because he explained his grandfather and his father had both died of huntington's disease and he had a sister who also had the disease mutation and had not yet succumbed to the disease but knew that was in her future. and it was heartbreaking to talk with him. it was also very motivating for me because i think huntington's is a disease

in fact, she's one of only two people in the world known to have the rare genetic disseisoni >> ir. she's my whole world. my son, too. she's unique. >> reporter: the diagnosis came as a result of her involvement with the stanford center for undiagnosed diseases, one of seven clinical sites worldwide with a team of doctors dedicated to investigating unidentified diseases. >> the technology and tools that empowered us to figure out what was going on with her weren't invented or were barely being used at the time she was born. >> reporter: more than 130 patients have been diagnosed through the program. they will be released tomorrow. >> our team here was carefully going back through that data trying to look at every genetic change she had as carefully as they could. >> reporter: her family can better understand their options for future treatment. >> i know she has something special, and i know she has a lot to give to other people. >> reporter: a strong girl trying to live her very best life. chris nguyen, abc 7 news. >>> that's a great smile. now to some consumer news and it begins wi

very precisely and delivers one or more or a dozen different genetic reprogramming instructions on just single genetic diseases and immunotherapy isn't really extends into regenerative medicine and the disease is well under have never met anybody and hopefully i will in the future but i've never met anybody who has a delivery guided nucleus thank you so much for the forward thinking and what you're doing that's andrea watson the founder and c.e.o. of like thanks andrea. that's it for this time thank you for being on board we sure had fun we're going to be doing more of it in the coming days but always catch. embossed on direct t.v. channel three twenty one dish network channel two eighty or streaming twenty four seven on pluto t.v. that's the free t.v. app channel one thirty two or you can catch as always at youtube dot com slash boom bust r.t. so on for now. is a. church secret indeed catholic priests accused of sexually abusing children can get away with it literally i like to call this the geographic solution so what the bishop needs to do then he finds out that the priest is is a pe

i thought that the old varieties haven't been intensely farmed so there's more genetic variability a greater range that's why they're more adaptable if your chin that potential is too narrow you can only survive in certain environments but not in others. older varieties have this potential for the book and thought this. is on a quest to preserve these older genetic types over the past three decades he's collected some five thousand seed varieties and since they're so robust they could play an increasingly important role in the process of addressing to climate change . organic produce isn't gardeners are also interested in these older varieties they perform better in soil that hasn't been sprayed with chemical fertiliser. these are from trying to grow these five thousand varieties in a five year rotation so it doesn't always work that we're trying to do a thousand a year we always take stock and say what variety is this how adaptable is it what's the produce like and we've documented all. bill get now a man is in charge of the garden weekends visitors come here to discover varieties t

definitely gives you an advantage it isn't just this issue it's a whole range of issues about where genetic and other bothers your fact is may give a particular athlete the edge over others i certainly think there should be as far as trying to gender intersection situations. going further the man i think would be an enormous task. in proportion hopefully there would be some kind of consensus and we could establish a regime for all sports where. the athletes who are transgender and intersex but also those who perhaps have other special unique physical attributes or biological genetic got tributes that they could be included or thank you joining us so far for the program here on our c still up and coming the mayor of a small french town is waging war on fast food giant mcdonald's but his big mac movement isn't going down too well with the locals details intimate. what politicians do something that. they put themselves on the line to get accepted or rejected. so when you want to be president. or somehow want to. have to go right to be close it's like i'm up for six three in the morning can't b