welcome. >> thank you. >> thank you. >> charlie: tell me about what is significant about gleevec. >>hat gleevec is done it taken chronic myoid leukemia with a le expectancy of thr toive years and turned it into a manageable disease wit a life expectancyhich we assume will be normal. and it's done that because we derstood precisely what drove the gloat of that leukemia and we develop arug to shut down that abnormaty, kill the cancer cells witut harming rmal cells. by doing that we generated an effective n-toxic pill that people take once

the results with this inhibitor in melanoma, gleevec-like results. there's 10, 15% of lung cancer patients who are just starting to see that we're turning the tied against cancer with this new paradigm. we're moving from an era of non-specific chemotherapy to very prehe'sly targeted drugs that are more effective and less toxic. >> charlie: that's the story. >> that's the real story on gleevec. >> charlie: what's the big unanswered question about cancer? >> one is why do cells get it in the first place. why do i get a mutation and you not. we know -- >> charlie: what are possible answers for that. >> we know that certain environmental exposures, smoking, obviously, exposure to chemotherapy for breast cancer can cause a patient to get leukemia later. damaging the dna in blood cells. but we don't know why most measures don't have these exposures. it could be just aging. cells as they divide and get older, it happens in copying the dna and mutation is created. if it's in the wrong cell that's probably what happens. >> charlie: go ahead. >> now charlie's

the resus with this inhibitor in melanom gleevec-like result there's 10, 1 of lung ccer patients who are just starting to see tt we' turning the tied againscancer with this new padigm. we're moving from an eraf non-specific chemotherapy to very prehe'sly tgeted drugs that are more effective and less toxi >> charlie: thas the story >> that's t real sry on gleevec. >> charlie: what' the big answered question about cancer? >> o is why do cells get it i the first place. why i get a mutation a you not. know -- >> charl: what are possible swers for tha >> we know tha certain environmental exposures smoking, obvious, exposure to chemotherapy forreast cancer n cause aatient to get leukemia later. damaging t dna in blood cells. t we don't kw why most measures don'thave these exposures. it uld be just aging. cells as they divide and get older, it ppens in copying the dna a mutation is crted. if it's in the wrg cell that's probably what happens. >> charlie: go aad. >> now charlie's aolutely ght. it's absoluty clear that the number of the people get cancer increa with age. that's absolutely clea