when this pastor, glenn keller, sent in a video, he was 350 pounds. >> i am at least 100 pounds overweightrst thing i need to do is make a difference in my life. >> now, he is under 265, and feels better since his military d days. >> denise castelli wants to take back her life by force, swimming, biking, running, even making an appearance on a u.s. open court. radio host jeff dauler said he was tired of being the fat, funny guy. >> i realized one of the only thing that any of us can control in our lives is our bodies, what we put in them, how we take care of them. >> reporter: down 25 pounds now, jeff says he still has one major problem, fitting his big head, he says, into a swim cap. but he is doing great. carlos solis is among them. >> i want to be able to -- to show my students that if you have diabetes, or that if somebody in your family has diabetes, you can break that chain of ever getting it. >> reporter: now he is down 80 pounds and is off almost all of his diabetes medications, and launched a run club at his school. more than 100 students are taking part. rick morris is a web desi

sanjay gupta and six other cnn viewers. >> reporter: nine months ago glenn keller pulled in to the parkingd chicken and then bought a webcam and sent us this. >> i'm at least 100 pounds overweight. >> reporter: keller, also runs a call-in ministry from the truck weighed 315. could only sleep with the help of a machine to treat the sleep apnea and knew if he didn't change fast, he was headed for a disaster. >> we are delighted to invite you to be a member of the six pack next year. >> reporter: we selected glenn as part of the triathelon challenge. since that moment, his life has changed dramatically. at our first meeting, his spirit was more than willing but it would sake time for the body to follow. a few months later, we met up again in hawaii. he was down almost 50 pounds, biked close to 20 miles, learned to swim in the ocean and walked his way through a 1-mile run. two months after that, glenn picked me up in his truck as he came to thereabout. atlanta. you just drove 800 miles. that right? >> yes, sir. >> reporter: just fitting in time to exercise must be challenging. >> really challe