wted toe ab to exore the rld, and th's what communy offere a way tt no her scho offered en i g to haard, i was able to function pretty well. and maybe, in part, it was cmunity that taut me tha it's iortant tchallee yoself in fferent ys, d it's n just about beg differt th's not o bus. (lghs) - [intviewer] it? - don't know. - [intviewer] it? that i that's r bus. all rit. i used to ri the bus ck and fth to counity evy day r the first cole of yes i used to ri the bus that was goi to commity. itas a lonbus ride o exted to gto schoo itathat dn't caree it dn't matt o ewhathe weather w. it didn'matter h cold, so this is the yea when ks decide ere they want to goo high sool. for while,he didn' wanto apply communi. and because counity's now so popular and it's a lottery, only onen fourids get and she sn't surthat she cann buyeah, shs deded she'gonna, e's gonngo in for the ttery. (students chattering) (upbt band mic) - th is e best d. welcomto the fst day school, 26-17! (crowd cering) we are slucky th we g to havell of our assembls in thi beautiful, beautiful place. st. anew's is pa of ourommunity

david liu of the broad instite, of haard and mit, is working on tools and techniques that will, one day, lead to the safe gene editing of humans. (upbeat stacca music) he's developing a new gene editing tool called prime editing. can you tell me a little bit about your work in that regard? - so the machines that nature provides us, like cspr-cas9, often don't do what we want them to do. the result of breaking that double helix mostrequently disrupts genes, to cause the deletion or insertion of small numbers of dna letters at the cut site. (staccato electronic music) - [kondwani] both crispr and prime editing technologies work by cutting dna. but in some sensitive situations, crispr technology can be too blunt of a tool. that's because it breaks both strands of the double helix. in rare instances, this can disrupt the gene in unintended ways. but, prime editing is more like a pair of tweezers. it breaks only one strand of the double helix, allowing scientists to very precisely change a single base pair. this is like changing one note in a musical score. - for most diseases with a genetic