if you look at hypertension or ohio cholesterol, we may be under prescribing. globally we haven't scratched the surface of what's needed to understand and stop drug resistance. i'll never forget, a few years ago i was in india where i worked for many years. i was at the all india institute of medical sciences, really a terrific harvard-quality institution there. i was in the intensive care unit. and this is soon after the -- the new delhi strain of a resistant organism was defined and described, and the head of the icu said i don't know why you're so worried about the new delhi strain of the organism. every patient in my icu has untreatable organisms. >> run out the door. >> try to avoid being in the hospital if at all possible. >> i will say from a global health standpoint, two things to add to what tom said. first, many of the people we serve in the poorest areas of the world don't have access to antibiotics. we certainly want effective antibiotics to get to where they're needed if you have an antibiotic-sensitive bacterial infection. and that includes -- ant