. >> jackie faust, thank you for being with us. >> thank you for having agios on the program. >> we wereut the stock going down today, being down overall basically what people are saying it's not a newsy start to this conference as many people had hoped for. they also talked about an analyst community that loves agios and we saw that today, that this is overblown what do you think of the investor action today? >> i think maybe there wasn't a whole lot new in what we were saying i've gotten very philosophical about short-term stock price movements. we're in the business of bringing beneficial therapies to patients and that's what we're going to continue to focus on. we talked a little bit about some of the milestones that we have coming up in 2020 that we're very excited about and we went a step further and put some stakes in the ground around where we think the company coulden in 2025. and many of the more financial type metrics around some of that guidance was probably largely expected by analysts and investors. we've been getting positive reactions in our meetings today, as you said th