james gallagher, bbc news. rajini: if you are a fan of the film like i am, you will be excited to know that the 2018 golden globe nominations are out. "the shape of water," a romantic fantasy about the cold war, leads the pack with seven nominations. other films that could win big are steven spielberg's "the post" and "three billboards." both have 6 nominations. for more, i was joined a short time ago by the former film editor for "time out new york." "the shape of water" seems to be leading the pack, but is that likely to take home the most awards? >> possibly eventually, but for the golden globes it is hard to say. what is great about the golden globes is they are a real wild card. they make the otherwise somewhat exhausting award campaign season really fun. the night itself is a blast, because there is not as much pressure as there would be at the oscars. it comes earlier in the season rather than later. anything can happen. i think "the shape of water," if it comes out the big winner, it could be a real con

james gallagher, bbc news. minority hazara community have been killed in recent years, targeted by extremists for their belief in shia islam. the solution, say the authorities, is tightly controlled army checkpoints at the entrance to the two districts where hazaras live. but many in the community say they've been made prisoners in their own homes. secunder kermani reports from quetta. hundreds of hazara men and boys are taking part in an annual shia ceremony of mourning. they are commemorating the killing of the prophet muhammad's grandson. along with the martyrs of the past, it is a day to remember those in the community murdered in the dozens of anti—shia attacks in recent years. this cemetery in the hazara district is where nearly 1,000 of those victims are buried. over a dozen hazaras have been killed in and around quetta in this year alone. in the past, the annual death toll was far higher. but the reduction in violence has come at a cost. hazaras are now living in ghettos, scared that if they step out of

james gallagher, bbc news.t. at the close of play they were 176—4, still needing 178 to win, on what could be a nail—biting final day. 0ur sports correspondent, andy swiss, reports from adelaide. was this the day england's flickering ashes hopes were gloriously rekindled ? first by the bowlers, they had to skittle australia to have any chance and they did, thanks to a five wicket masterclass from jimmy anderson. that still left england a record run chase, 354, and after a good start they faltered. both openers went before james vince wafted his wicket away, and it seemed england's chances. commentator: edged and gone. handscomb takes the chance. but under the floodlights and the fiercest pressure, dawid malan and joe root hung in there. australia kept appealing, england kept surviving — just. it was pure sporting theatre. but moments before the close, malan fell. australia are still favourites, but england 178 runs from something very special. well, this has been some fightback from england. barely 24—hours ago

james gallagher, bbc news. our top story this lunchtime...at the brexit talks in brussels. coming up in sport... iam i am live in hull where this evening we will find out which artist is taking home the most prestigious prize in contemporary art, that turner prize. it's the final round of matches in the group stage of the champions league tonight. manchester united are hoping to secure top spot and qualification for the last 16. it's been described as a planetary crisis and now environment ministers meeting in nairobi have agreed that plastic waste needs to be stopped from entering the world's oceans. scientists say they're shocked to discover the effect plastics can have on marine life, endangering animals such as turtles which can swallow foreign items in the ocean. the united nations resolution, which is set to be sealed tomorrow, is not legally binding. but ministers hope it will set the course for much tougher policies. our environment analyst, roger harrabin, reports. the plastic epidemic is everywhere. here volunteers are clearing up a

our health correspondent james gallagher reports.orjake omer. he was born with haemophilia a, a genetic defect that means his blood did not clot. the slightest injury used to mean severe bleeding. even a long stroll would cause bleeding in hisjoints. but no more. i think the gene therapy has hopefully given me a new lease of life. it's going to allow me, as my boys grow up, to be a lot more active with them, so kick footballs around, climb trees with them, to hopefully run around in the park with them, and not be someone who has to worry about what i'm doing. jake's body struggles to produce a protein for clotting of blood called factor eight. he was one of 13 patients given gene therapy last year. a virus was used to give his body new instructions for making factor eight. all of the trial patients are off their haemophilia medication, and 11 have roughly normal levels of blood—clotting proteins. if this is how much factor eight you or i produce, well, this is how much is produced in a haemophilia patient. but you can see after the g

james gallagher, bbc news. it was a surprise visit by vladimir putin.roops on as he put it routeing out international terrorists. he was there to announce that a significant part of russia's military would be withdrawn from the country. but waiting to surprise him was the syrian president, bashar al—assad. the two men hugged on meeting. the bbc‘s moscow correspondent steve rosenberg reports. for more than two years, his troops have been at war in syria. today, vladimir putin made a surprise visit to the russian airbase here. his message — mission accomplished. here to see him, and to thank him, was president assad. it's russia's military operation which has kept the syrian leader in power. and then it was onto the soldiers. president putin told the troops, their motherland was proud of them. he expressed russia's gratitude for what they had achieved in syria. addressing the troops, president putin said that the russian and syrian armies had routed the most fearsome group of international terrorists. he announced the withdrawal of a large part of russia'

and james gallagher is here.t day, but as some people have said it is not a treatment or a cure, are they right to make all these ambitious claims? the thing about these diseases is that they're some of the most intractable problems in all medicine. if you have parkinson's, huntington's, dementia, there is no cure or a huntington's, dementia, there is no cure ora drug huntington's, dementia, there is no cure or a drug to slow the pace. i have been following the research for two years and it is the first hint ofa drug two years and it is the first hint of a drug that can slow the pace of one of the diseases. it needs more research. so it is generating real excitement, because it is targeting the fundamental cause of these disease and beyond huntington's it may show the way to more complicated diseases. thank you. snow and ice in some areas have led to the closure of hundreds of schools in wales and central england today, while hundreds of homes in the west midlands and 0xfordshire are facing power cuts for a secon

the bbc‘s health correspondent james gallagher reports.s. they have seen their mother, stephanie, die from it. the last year of her life, every time we all went to visit her, she just held us and said, i want to die. the disease claimed their uncle keith and grandmother 0live too. they describe it as parkinson's, alzheimer's and motor neurone disease all rolled into one. when you've got something that's degenerative, you know that — every day, you know the last day was probably better than the next one's going to be. frank, his sister sandy and also their brother peter's brains will all slowly degenerate from huntington's, too. but now, they have hope. the treatment is called gene silencing. every cell in the body contains genes, which hold the instructions for running the body. huntington's disease is the result of a corrupted gene, that leads to the creation of a toxic protein which destroys the brain. a messenger carries the blueprints from the corrupted gene. this treatment sticks to the messenger, disabling it, and lowering the produc

here‘s our health and science correspondent james gallagher.t that means is blood did not plot. the slightest injury used to mean severe bleeding. even along straw would cause bleeding in hisjoints. but no more. the gene therapy has given me a new lease of life. it will allow me to be a lot more active with my boys as they grow up. kick footballs, ru na round active with my boys as they grow up. kick footballs, runaround on the part, climbed trees, and not be someone part, climbed trees, and not be someone who has to worry what i am doing. jake was one of 13 patients given pioneering gene therapy last year. a virus was used to give his body new genetic instructions for clotting blood. all of the trial patients are often haemophilia medication and 11 have roughly normal levels of blood clotting proteins. this is huge. it is groundbreaking. the option to think about normalising levens in patients with severe haemophilia is mind blowing. to offer people the potential of a normal life, they have had to inject themselves every other day to prevent b

james gallagher, bbc news.re finishing earlier than normal on thursdays this month because next on thursdays this month because next on the bbc news channel is meet the author. sometimes, an author makes a big demand of a reader. nick harkaway does that in his novel gnomon — an intricate, complicated story on a vast canvas, set in a future britain where we're living in a surveillance state, although it's one that most people seem to believe is fundamentally good. but this is, among many other things, a murder mystery. something's gone wrong and there is a fiendish puzzle, many fiendish puzzles, to be solved. gnomon, after all, is the name for the part of a sundial that casts a shadow. welcome. it is a tough challenge for a reader, this book. you even put a puzzle on the frontispiece, which is like an entry test for gchq. something encrypted. you're saying right from the beginning, look, i hope in a good way, but you're going to have to work at this? yeah, absolutely. and it's actually not the only puzzle in the

james gallagher, bbc news.d to make crude comments about women. the tv host — who was with mr trump at the time — said there was no doubt over his remarks. take a look at this. last week for some reason he came out with that is not my voice on the tape. you cannot say that, i was there, you were there, that is your voice on the tape. 20 women do not get together and say it would be fun to ta ke get together and say it would be fun to take down a powerful guide together. i said ok, you're reopening wounds, enough is enough, stop playing around with up that upset him. —— with people's lives. billy bush was fired by nbc news after the tape came out because they felt he had been enabling the president in the commons that he was making. there is some speculation that all the things billy bush is doing at the moment, he has exposed a lot of these sexual harassment cases in the new yorker magazine, some kind of retrospective rehabilitation going on on his part is the allegation. whether it is hail to the chief or a cu

james gallagher, bbc news.him as a production assistant in 1985. oliver said he thought the apology over those claims have felt like a dismissal.|j get claims have felt like a dismissal.” get no pleasure from this conversation. she wrote this one line ina conversation. she wrote this one line in a diary. saying no one is 100% good or bad. dustin is a pig but i like him a lot. that is both extremely generous and damning. do you believe all the stuff you read? i believe what she wrote, yes. because there's no point in her lying. there is a point, she has not brought this up for four years. an mp has broken down in tears in the commons after hearing how some people are struggling to cope as the result of welfare reforms. the backbencher was reacting to frank field has said he had to persuade one of his constituents to kill himself because he did not have enough money for food. how does an mp persuade someone to give them hope when i do not have hoped for them that things are going to radically improve, and what we

james gallagher, bbc news.oblems for commuters. first of all, this is austria. winds have reached 106, monitors per hour, across the alps. trees have been bought down as well as power poles and other buildings as well. these pictures from france, traffic workers using an enormous amount of great just to get some workers using an enormous amount of greatjust to get some lorries going. you will see here, these pictures from italy where we know italian roads were very badly hit, this truck came a cropper. these pictures from naples where the port saw many ferries stuck. unable to go anywhere because the wind was just too strong. and at heathrow, the picture tells the story. a quarter of flights had to be cancelled because of bad weather. anyone flying in out of heathrow is advised to check the website, to be sure that plane is taking off. let's get more on this... a blanket of snow, covering large parts of the uk. an ideal playground for children, many of whom have had the day off with hundreds of schools closed d

james gallagher, bbc news.rkinson's uk. thanks forjoining us, gene silencing, i'm assuming you have been aware of the work that's been going on looking at huntington's and perhaps whether it is applicable to parkinson's? that's right, this is a very important step forward for huntington's and for other disorders like parkinson's which affects about 127,000 people in the uk at the moment. it could be a major step forward. huntington's is a slightly simpler disease because we know it isa simpler disease because we know it is a single gene mutation, causing huntington's, whereas for the majority of people affected by parkinson's we don't fully know what the causes are. there are a subset of parkinson's patients where it's caused by a genetic mutation, similarto caused by a genetic mutation, similar to huntington's, so certainly for those people this could be a major breakthrough. as you mentioned in your piece, they are altered proteins which are commonly found in a lot of neurodegenerative disorders and parkinson

our health correspondent james gallagher was given exclusive access to the trial and has this report.ng that's degenerative, you know every day, the last day was probably better than the next one is going to be. this family has been blighted by huntington's, they have seen their mother stephanie, uncle keith and grandmother lived all dying from it. they describe it as parkinson's, alzheimer's and motor neuron disease rolled into one. frank, his sister sunday and also their brother peter's brains will all slowly degenerate from huntington's too but now they have hope. the treatment is called gene silencing. huntington's disease is the result of a corrupted gene that leads to the creation of a toxic protein which destroys the brain. a messenger carries the blueprint from the corrupted gene. this treatment sticks to the messenger, disabling it and lowering the production of the toxic protein. 46 patients had to be experimental drug injected into the fluid that babes the brain and spinal cord. the therapy was safe and effective, led by scientists at university college london, who say the

our health and science correspondent james gallagher has had exclusive access to the trial and joinsand one which is passed through the generations. a blight on families, terminal, if you have it, you know you will die, you will have seen a parents die from this disease, and there is a 50/50 chance of you passing it to your children. it is caused by the build—up of a toxic protein inside the brain, slowly killing brain cells over a lifetime. what this drug does, it is injected into the spinal fluid, it will bathe the brain and slow down the production of a protein. the hope is that once you lower levels of the protein, then you can stop brain cells dying and that might stop huntington's disease. people will want to know, people have this already, people could have it in the future, those people will want to know, is this a cure? today, the a nswer know, is this a cure? today, the answer is no, because scientists so far have only shown they can lower the levels of the toxic protein, they have not lowered it long enough to see if it makes a difference, a decade of animal research sugge

james gallagher, bbc news. estimate is based on interviews with some of the 600,000 rohingyas who've fled to neighbouring bangladesh. the burmese armed forces have stated that about 400 people died, describing most of them as muslim terrorists. president putin of russia has been quick to defend us president trump — and his own government — when asked about alleged collusion between russia and the united states, to swing the result of last year's election in trump's favour. president putin made the comments during his annual question and answer session. it's one of the great set pieces of russian political theatre, and it also tends to last for quite some time. mr putin got events under way a few hours ago. today is expected to be one of the busiest days of the year for our national postal service the royal mail. they're aiming to deliver ten million parcels and 10s of millions of letters today as customers rush to complete their deliveries before christmas. ben thompson is at a sorting office in manchester. wel

james gallagher, bbc news. two diabetes. there is an estimated 4 million people with type two diabetes and another 12 million at risk. finding ways to put this into remission could have enormous benefits. that word remission, because people believe they have got this for life? this research is changing that conversation. what this particular trial found is under half of those who took part were in remission under 12 months. which means they don't have diabetes any more and it is very exciting. this isn't a quick fix, it is tough to get to? 800 calories a day for up to five months. one of the participants, isabel talks about how difficult it was and how the support of her family around her was important. what does that do too, going on to a diet of that sort, you must be very tired, what are the other symptoms? it can depend from person to person. some found it more difficult than others. anyone thinking of taking part, it is essential you speak to your health care professional, because it can be dangerously few

trust used gene therapy to correct the defect in a small safety trial. 0ur health correspondent james gallagher a genetic defect that means his blood did not clot. the slightest injury used to mean severe bleeding. even a long stroll would cause bleeding in hisjoints. but no more. i think the gene therapy has hopefully given me a new lease of life. it's going to allow me, as my boys grow up, to be a lot more active with them, so kick footballs around, climb trees with them, to hopefully run around in the park with them, and not be someone who has to worry about what i'm doing. jake's body struggles to produce a protein for clotting of blood called factor eight. he was one of 13 patients given gene therapy last year. a virus was used to give his body new instructions for making factor eight. all of the trial patients are off their haemophilia medication, and 11 have roughly normal levels of blood—clotting proteins. if this is how much factor eight you or i produce, well, this is how much is produced in a haemophilia patient. but you can see after the gene therapy trial it's almost up to normal.

here's our health correspondent, james gallagher.een blighted by huntington's, they have seen their mother stephanie, uncle keith and grandmother olive all dying from it. they describe it as parkinson's, alzheimer's and motor neuron disease rolled into one. frank, his sister sandy and also their brother peter's brains will all slowly degenerate from huntington's too but now they have hope. the treatment is called gene silencing. huntington's disease is the result of a corrupted gene that leads to the creation of a toxic protein which destroys the brain. a messenger carries the blueprint from the corrupted gene. this treatment sticks to the messenger, disabling it and lowering the production of the toxic protein. 46 patients had to be experimental drug injected into the fluid that babes the brain and spinal cord. the therapy was safe and effective, led by scientists at university college london, who say the results are of ground—breaking importance. for the first time we have the potential and hope for a therapy that one day may slow

our health correspondent james gallagher reports.lia a, a genetic defect that means his blood did not clot. the slightest injury used to mean severe bleeding. even a long stroll would cause bleeding in hisjoints. but no more. i think the gene therapy has hopefully given me a new lease of life. it's going to allow me, as my boys grow up, to be a lot more active with them, so kick footballs around, climb trees with them, to hopefully run around in the park with them, and not be someone who has to worry about what i'm doing. jake's body struggles to produce a protein for clotting of blood called factor eight. he was one of 13 patients given gene therapy last year. a virus was used to give his body new instructions for making factor eight. all of the trial patients are off their haemophilia medication, and 11 have roughly normal levels of blood—clotting proteins. if this is how much factor eight you or i produce, well, this is how much is produced in a haemophilia patient. but you can see after the gene therapy trial it's almost up to no

breakthrough — which could ultimately stop the deadly disease. 0ur health and science correspondent james gallaghernerative disease, it is described as the biggest in 50 years. described as the biggest in 50 year5. huntington‘s described as the biggest in 50 yea r5. huntington‘s diseases described as the biggest in 50 year5. huntington‘s diseases caused by the build—up of a toxic protein in the brain. that kills brain cells. you cannot stop it. eventually, it is fatal. thi5 cells. you cannot stop it. eventually, it is fatal. this trial, a experimental drug injected into the spines of patients, a fluid... it has interrupted the production of the protein. lower levels of the toxic protein in the brains of patients for the first time. it is a big deal. no one is saying it is a cure. what are they suggesting this finding might mean? it is definitely not a cure. what we know from a decade of animal research is that if you do this in animals, they do not get huntington‘s disease or huntington‘s disease does not progress. the thing to do now is to do longer trials in human patients. that will tell us whet

james gallagher, bbc news.es, prince william, and theresa may, will be among the 2,000 people who are expected to attend. 0ur correspondent, frankie mccamley is at st paul's. good morning. good morning. the main focus of today's service is really going to remember those 71 who lost their lives in six months ago. it is also a chance to thank the emergency services who came to help, and for all of those affected to come together to hear those messages of support and to make sure this is something that is not forgotten. we are expecting 2000 people here today. not only survivors, career families as well. and also those who came together to give up their time and charities and those who came together to support those on the ground. —— bereaved. politicians will also come. theresa may and jeremy corbyn and also the royals. the counsellor has been told to stay at home. it shows the friction over the last six months. today will be a very emotional day. this will be the first time many people have seen each other since

james fuller. ibolya gabor. amy that gallagher. matthew gannon. nski.th raymond garczy paul garrett. gibson. william david giebler. olive gordon. gordon-gorgacz, gtalin, and loretta anne orgacz. david gold. karen hunt. nicole at jane hall. lorraine francis halls. linda hart to the end. pamela herbert. rodney peter hilbert. alfred hill. catherine hollister. josephine hudson. melina hudson. sophie hudson. roger hearst. alexander loewenstein. hurst.r alexander loewenstein. we remember them. elizabeth ivell. khalid jaafar. then houghton -- robert van hourten jeck. apologetic jefferies. rachel jeffries. beth johnson. mary lincoln johnson. timothy baron johnson. christopher andrew jones. julianne frances kelly jay joseph kingham >> we remember them. patricia ann klein gregory kosmowski elke etha kuhne minas christopher kulukundis, ronald albert lariviere maria nieves larracoechea maria nieves larracoechea robert milton. william lever. wendy lincoln. lloyd ludlow. maria lurbke. uarrie.acqa douglas mela caught. -- malicote. >> we remember them. malicote. elizabeth merrick. lewis marengo. noe

gallagher. now back to hannity. ♪ ♪ >> sean: welcome back to hannity. we have more reaction to this blockbuster news about jamesneration of hillary before the investigation was even complete. let me just stay on what he is exonerating here. because we know the mishandling of classified top secret, special access programming: mom and pop shop bathroom. we know that she destroyed such information. we know that she lied when she said she didn't have this information on there. that she didn't send a receipt. that's been debunked. then you have the whole thing about deleting 33,000 subpoenaed emails. then you have the acid wash and the use of bleach bit, most americans had never heard of it before. then you have an aide busting up devices, blackberries and the like with hammers and the only thing they turn over to the fbi in terms of a device is one without a sim card, rendering it useless for the fbi. now, that sounds to me. it is obvious that laws were broken here. and that we now know five foreign agencies tapped into that particular server, that compromised national security. does that mean now the fix is in wit