you mentioned it was 1817 when james parkinson described it. it took another 100 years, basically before we knew anything more about parkinson's and that was in 1912 and 1917, two important papers on the pathology of parkinson came out. in 1912, certain neurons were in the brain of people who died of parkinson's disease. in 1917, a russian, who was a medical student in paris, studied parkinson brains and he wrote his paper describing the substabsifying rapart of the basal ganglia was involved in parkinson's. if you look on the left, you see a dark band on each side of the midbrain. this dark band is called the substandpointia nigrim. there is decreased pigment. if you look on the right half you see a parkinson's brain, and there is decreased pigment, and if you look under the microscope, you see cell loss in the suwstantia nigra. he called it louie body. if you look at the graphic, you see a nucleus in the cell, and just below that and a little bit to the right is inclusion called the louie body. it is found within the sighto plasm of the cell a