jenny walrond, bbc news, manchester. we seen the doctor from cancer research uk in that report. looked at women with a family history of breast cancer. notjust looking at a broad population of women across the country, it was only women with a family history. they looked at small genetic changes to letters of dna, then the population, but looking at then the population, but looking at the small changes linked with the risk of breast cancer in people with afamily risk of breast cancer in people with a family history of the disease and they found by homing in on a small number of changes, they could accurately predict the risk these women would go want to develop breast cancer. at the moment, in terms of genetics, we only know about the genes behind 25% of cases of women developing breast cancer who have a family history of the disease. people with disabilities caused by the drug thalidomide say they've made a big breakthrough in their campaign for compensation from the government in germany, where the sedative was manufactured. about a50 babies in the uk were born with disabiliti

jenny walrond, bbc news, manchester. time for a look at the weather now.n, as we weather fronts move across the uk. one of them overnight will take cloud eastwards, some outbreaks of rain, especially in scotland. in the northern half of the uk it could be a bit drizzly at

jenny walrond, bbc news, manchester.blast in the capital accra last night sent a giant fireball into the sky, forcing residents to flee. it‘s understood to have triggered a second explosion and a fire at a nearby petrol station. north korean leader kim jong—un‘s sister has been promoted. seen here on the right with her brother — kim yo—jong is 28 years old. she replaces her aunt in the politburo. the promotion is further evidence of the kim family grip on the north korean regime. close to four tonnes of cocaine has been seized after a ship was intercepted in the atlantic. the spanish authorities acted on intelligence provided by the national crime agency in the uk to intercept the boat between madeira and the azores. the nca says, if sold, the cocaine would have fetched more than £200 million. seven men have been arrested. the duke of cambridge and prince harry have been very open about their own experiences with mental health, and set up their charity heads together to encourage people to speak out. now they‘ve announce

our health correspondent jenny walrond's report contains flash photography.ht against cancer. charley and annie were tested for the brca gene mutation after losing family members to breast and ovarian cancer. charley was a carrier and given up to an 87% risk of breast cancer. annie wasn't but was told she had up to 50% chance. as a result, both had mastectomies. 87% is pretty high so to me, ijust wanted to get rid of them as soon as i could. had the risk been a bit lower, i would have maybe thought twice about it, and been a bit calmer about the situation and perhaps gone for regular screening as opposed to such drastic surgery. i always thought that they would kill me so i wanted them off. so it was all to do with mindset, really. but, no, it is a big operation and it is, um, something that is life changing. the women's chances of developing breast cancer could have been much lower but it was not possible to tell. charley has the same brca gene mutation as the hollywood actress, angelina jolie, who had her breast tissue and ovaries removed after also being t

jenny walrond, bbc news, manchester. time for a look at the weather now. after many of us enjoyed a sunny sunday, a cloudy monday on the horizon, as we weather fronts move gci’oss horizon, as we weather fronts move across the uk. one of them overnight will take cloud eastwards, some outbreaks of rain, especially in scotland. in the northern half of the uk it could be a bit drizzly at times. some clear spells and parts of southern england, particularly the south—east, where some fog patches could develop. for many of us, a cloudy and mild night and start monday. on monday, as another week weather from luton, expect a lot of cloud, a few bright and sunny breaks to the east of high ground. where the cloud is thick enough, a bit of drizzle. a better day in western scotland in bed with today, some outbreaks of rain in northern ireland by the time we get to the evening and temperatures 14—17. the weather becomes more active as we go through this week with stronger winds, some wet weather, especially in north—western parts of the uk but warmer, especially in the

our health correspondent jenny walrond reports. it's sometimes known as the angelina jolie gene.urgery to remove her breast tissue and ovaries after learning she had a brca gene mutation. one in 400 of us have it. women who test positive for the brca mutations are told their risk of breast cancer is up to 87%, but the risk could, in reality, be much lower. scientists have developed a test that looks at 18 genetic variants that can affect the likelihood of having breast cancer. using these common variant tests and putting them all together in a package means that we can get far better, far more accurate ideas about the risks women are likely to have in their lifetime. this research could make a huge difference to the choices made by women with a family history of breast cancer. scientists here believe it could cut the number of patients having risk—reducing surgery by a third. the more that we learn about the genetic components behind these increased risks of developing breast cancer in women who have got a family history of the disease, the better they can make choices about thei

jenny walrond, bbc news, manchester. with news of lewis hamilton's win injapan and the rest of the day's sport let's cross to lizzie greenwood—hughes at the bbc sport centre... thank you. lewis hamilton is on the verge of winning his fourth formula 1 world championship. he eased to victory in the japanese grand prix while his nearest rival sebastien vettel was forced to retire. patrick geary reports. one man and his mercedes. a tender moment between lewis hamilton and the car that might carry him to a fourth world title. they started as so often in front, his main rivaljust behind him. that was as close as sebastien vettel would get as hamilton sped off, that'll lost power, his car developed problems at the wrong time. spark plugs with the issue, that might that sebastien vettel reversed out of the title race. he was left to channel his hopes through others in particular max verstappen, the next big star. he beat hamilton in the last grand prix and chased him in the final stages, hamilton lost speed but never composure.

jenny walrond, bbc news, manchester. the headlines in a moment.ime for a look at the weather now with nick miller. hello, after many of us enjoyed a sunny sunday, a cloudy monday on the horizon, as weak weather fronts move gci’oss horizon, as weak weather fronts move across the uk. one of them will overnight take a lot of cloud eastwards. some outbreaks of rain in scotla nd eastwards. some outbreaks of rain in scotland but elsewhere in the northern half of the uk, a bit drizzly uptimes. some clear spells holding on in southern england, especially in the south—east, where there could be some fog patches. for many of us, a cloudy and mild night and to start monday. on monday, as another week weather front comes in, a lot of cloud, a few sunny breaks to the east of high ground, where the cloud is thick enough, a bit of rain and drizzle. a better day western scotland compared with today, some outbreaks of rain in northern ireland by the time or get into the evening and temperatures around 14—17. the weather becomes more active for a time as they go th