about patients what weren't able to li and work whose lives are transformed, it's really incredible kushlggo boys had to receive factory replacement because they're missing a factor that causes them to bleed. they would need factor replacement daily. then we had kind of the long acting factors, which are now being lunched by novo and by -- these basicry are two to three times a week, it's a little better, but -- not as combersome as before. potentially you could launch and have gene therapy for that factor, but you give the patient a gene yes. that's the whole point >> we're running out of time, but do you feel like we'll get a quantum -- it's a tv show. a quantum leap in all of the -- we've learned so much over the past 10, 15 years in basic science. some of it has made its way to the clinic or to the hospital bed, but i don't know. are you -- i'm frustrated by how much we know and how hard it is to design therapy mukts. there are so many things, testing and so many side effects and everything else. we know so much more yu i'm just looking for ration a.m. drug design lock and key type the