after three months of treatment, maki's large tumor shrink dramatically. this was followed pie surgery to remove caps rouse tissue plus retreatment with tarceba. today, seven years after her diagnosis, her doctors can detect no since of cancer. what's more, during the extra time provided by this approach, maki completed a triathlon, landed her dream job as a biology professor at ithaca college, and welcomed a healthy baby girl. clearly, we need many more stories like maki's. that is our dream, and i'm sure it's yours, too. with your support, we can realize our vision of invigorating discovery from basic scientific inquiry to more precise personalized approaches to treatments and cures. so, thank you, mr. chairman. my colleagues and i now welcome your questions. >> thank you very much, dr. collins. and just for the members of the committee, we're going to go first to our chairman and our ranking member and then we'll go through our normal order in terms of questions. so, mr. chairman, you're recognized for whatever questions you care to pose. >> thank you,

and after three months of treatment, maki's large tumor shrunk dramatically, as you can see. this was followed by surgery to remove cancerous tissue plus retreatment with the drug. today, seven years after her diagnosis, her doctors can detect no signs of cancer. what's more, maki has now completed a triathlon, landed her dream job as a biology professor at ithaca college, and welcomed a healthy baby girl. maki is the face of scientific innovation, made possible by sustained investments in biomedical research. with your support, we can realize the vision of accelerating discovery across the vast landscape of biomedicine, from basic science inquiries to more precise personalized approaches to treatments and cures. so thank you, mr. chairman. my colleagues and i welcome your questions. senator alexander: thank you dr. collins. dr. hamburg? dr. hamburg: thank you, mr. chairman, and members of the committee. i'm very pleased to be here today to discuss our shared goal of speeding innovative treatment to patients. i look forward to working with you on this important effort. as you

and after three months of treatment, maki's large tumor shrunk dramatically, as you can see. this was followed by surgery to remove cancerous tissue plus retreatment with the drug. today, seven years after her diagnosis, her doctors can detect no signs of cancer. what's more, maki has now completed a triathlon, landed her dream job as a biology professor at ithaca college, and welcomed a healthy baby girl. maki is the face of scientific innovation, made possible by sustained investments in biomedical research. with your support, we can realize the vision of accelerating discovery across the vast landscape of biomedicine, from basic science inquiries to more precise personalized approaches to treatments and cures. so thank you, mr. chairman. my colleagues and i welcome your questions. senator alexander: thank you dr. collins. dr. hamburg? dr. hamburg: thank you, mr. chairman, and members of the committee. i'm very pleased to be here today to discuss our shared goal of speeding innovative treatment to patients. i look forward to working with you on this important effort. as you

and after three months of treatment, maki's large humor shrunk dramatically, as you can see. this was followed by surgery to remove cancerous tissue plus retreatment with tarcibap today seven years after her diagnosis her doctors can detect no signs of cancer. what's more, she has now completed a triathlon landed her dream job as a biology professor at ithaca college, and welcomed a healthy baby girl. maki is the face of scientific innovation, made possible by sustained investments in biomedical research. with your support we can realize the vision of accelerating discovery across the vast landscape of biomedicine from basic science inquiries to more precise personalized approaches to treatments and cures. so thank you mr. chairman my colleagues and i welcome your questions. >> thank you, dr. collins. dr. hamburg? >> thank you mr. chairman, and members of the committee. i'm very --. thank you mr. chairman and members of the committee. i'm very pleased to be here today to discuss our shared goal of speeding innovative treatment to patients. and fda looks 2350rd to working with

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but obvious any woman or man maki a dmatic decision sould only do so aft csultingi doctors. >> absolelyeveryone it is individl, consult your dcr. >> coming up on "action news" toght, opportuty in space. the nasa mars rover hits a milesto. >> and change in pla is keepinamin forces for a lonr period of time in aghant. >> plus on "healthcheck," sou i say this? th're great! mang brefast cereal and xho chocoteandme nutritious. >>> going to wet, winter is not done with us ye i elaiinhe forecast. >>> a jeffery lurie talks about t wer shuffle in t eagles'ront officehe "acti newsctinues tight. you get sick you can't breathe through your nose... suddenly... you're a mouthbreather. well, put on a breathe right strip and instantly open your nose up to 38% more than cold medicines alone so you can breathe and sleep shut your mouth and sleep right. breathe right. > esidentba said today he i ing tsw do the wtrawal of the last 10,000 american trps fro agnistan. a a joint news conference obama said the schedule f the final pull-out hasot changed, bt the delay drawdown during the fighting season will hel

apple makie ing splash with yesterday's watch reveal. could it have on the watch industry? could it do the same for wearables the iphone did for smart phones. let's bring in brian who spent the last four years studying the watch industry. the big question here is, can this product cause a culture shift? there are a lot of risks these days that don't have a watch on them like they used to. >> this is the big question. right now we're sort of wondering is this category actually fully formed and real and what we know from studies, only about a quarter of teens are even wearing watches today and so this category generally has been unproven but when apple enters a category like this they prove it very clear and this is a war for real estate, you know, risk real estate. >> how much are teens spending on watches the quarter that have them? i bet it's nowhere near 350 bucks? >> it's a totally different market. you see the teen market in many of these is the infusion of the fashion brands that have happened in the last four or five years, but thi

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when michael was tie -- when maki was diagnosed with cancer, it was completely unexpected. she had never smoked a day in her life. she had little survival beyond -- little chance of survival beyond a year or two. doctors assist acted she might have -- suspected she might have a genetic mutation. testing confirmed their hunch and she was prescribed a drug that blocked a specific signal. after three months of treatment her large tumor shrunk dramatically. this was followed by surgery to remove cancerous tissue. today, seven years after her diagnosis, her doctors can detect no sign of cancer. what more, during the extra time provided by this approach, she completed a triathlon, became a biology professor at ithaca college, come to healthy baby girl. clearly, we need many more stories like hers. that is our dream and i am sure it is yours as well. with your support, we can realize our goal of developing more scientific inquiry to precise are several approaches for treatments and cures. and you, mr. chairman. my colleagues and i welcome your questions. mr. cole: thank you, dr. c

shake . [ giggs ] are you maki them for the easterunny no, you.female announcer ] this eter. bring a tradition... out of its sll. rice kspie® iid it! u di what'sapped tonackg?how d itecom abnt-mdedl eati onefterhe nt? we are areamchee tha stl beeves in saving r fo. thlaugng c. inve snaing. >> reporter: washington d.c. been getting absolutely pounded was no off. this was bad enough that the national weather service attention even torture issued a winter weather advisory look at right now we still see the reconditions run of the storm is still expected to hit later on this morning. they are expected to get the brothers from 6 in. the fall next eight hours. esther and the low to warrant some havoc on the road but certainly in boston yesterday will be getting more snow. already had over hundred inches this year and that record. this not appear in our forecast summary and weather on tonight in the meantime if all conditions out there right now is closely see here giving us such a wonderful son was shot as part of that system. this could very well bring

shake . [ giggs ] are you maki them for the easterunny no, you.ncer ] this eter. bring a tradition... out of its sll. rice kspie® iid it! u di ♪ i lo my ta hlth rs. because en nritis taes is dicio i n't ss t oth stu. metaealtbars helpromo hea heah. expeencehe ma efct wh our lti-althellns line ♪ >>mark: tear or problem was about 580. >>george: no time soon is going to be probably hours of memo of four hours before they're able to get any lines clear here all and interstate 880, westbound. >>george: this is the location of the accident at university avenue and before those of the traffic impact was go out to kron 4 jackie the who was the covering this event for us this morning. >>jackie sissel: that is right where come from windsor and headed to san leandro i just out to sea its feedback as to make the load and the driver confirmed to be 20,000 lbs. which is 10 t of material with they're looking at right now as you said it is large laminated beams and also a prefab the roof level on a commercial building and the driver simply lost control of the loa