with me is matthew bartels, professor of physical medicine and rehabilitation. and while you're a medical center in new york, welcome back to our program. matthew. as we just saw, the report abnormalities in the blood could be a cause of long could it, could this finding help in the prevention or even therapy of it? this is a very interesting finding because, you know, we have not really to this point understood the exact causes of long code and it is a systemic type of disease and manifests in many ways as you have in your intro piece. the idea is that something that the blood of malady may contribute to a systemic diseases is not at all something that would be unusual. many people are familiar with sickle cell and although that's a genetic condition and very different having ever maladies with the blood cells, they are cause many effects including central neurological symptoms, t cause muscular skeletal complaints problems with the joints. so having something that is present all throughout the body like blood showing these long term abnormalities may be a very