cnbc's meg tirrell >> in a meeting today, the cdc noted boosters increase the level of antibody levels we have seen in other age groups as well. there were no new safety issues identified the main concern for these vaccines is a rare heart risk called myocarditis after booster doses, it is expected to be lower the risk of myocarditis is higher than the vaccine. this would be the third dose for most kids, although it would be the fourth who are immun immunocompromised. getting that extra boost would go a long way. >> does this mean anything for the timeline for kids under the age of five getting approved for the shot >> yeah, there was a lot of discussions of that today. one of the advisers urging the fda at the end of the meeting to move as quickly as possible. right now moderna's application is in and pfizer is expected soon the fda is expected to review them soon. >> meg tirrell, thank you very mump. >ch much. >>> there will be no punishment for boris johnson for breaking covid laws one of them boris johnson. british officials fined him last month making him the first prime min minis

where people are still hospitalized after the rebound of symptoms and that seems to be more rare >> meg tirrellyou. in a southern california ape shooter first used chains and super glue to look the door, he called five and hurt tee others. >> the heroic actions of the congregation are what they want you to hear about. >> watch byron brown on the people of his city and hugh his community is responding as we approach the bottom of theou >> as we begin this new week, our community continues to grieve and heal. we are a strong community. we are rallying around one another and we will continue to move forward as a strong city of buffalo, county of erie in western new york region. >> the mayor of buffalo today. people in this community are grieving after a self-proclaimed white supremacist opened fire on people in a supermarket here, killing ten. as we reported, the 18-year-old suspect is now behind bars he pleaded not guilty to murder, but as this case plays out in court the mayor says the community of buffalo has a lot of healing to do mayor byron brown is with us now. thank you for your time. how

mid-sized names and it was coming off about a 25% down month as the broader sector slumps let's get to meg tirrellmoving higher meg? >> kelly, it looked a lot better earlier in the day and even having conversations with people in the biotech and health care space, was there not a lot of conviction that this game would hold and we are seeing you give back some of that and you're seeing the smaller names within the xbi and seeing some pretty big moves today. we'll start with bridge bioup 10% and we have a licensing deal and oncology with bristol myers perhaps contributing to that and turning point therapeutics the biggest moves in the xbi among names of $500 million market cap and they're still among some of the smaller names and among the bigger biotechs you're not seeing such strong moves and it's been an incredibly tough year for biotechs in general. over the last week, you're sighing the xbi and the ibb both down and the xbi down there almost 15% in the last week alone and this is despite, kelly, some much-needed m & a that we saw earlier in the week from pfizer and biohaven for the year, you're

shep. >> all right meg tirrell, good weekend.hank you. >>> anna delvey wants to tell her story again. the tale of the fake german heiress played out on netflix. now she is launching a new business plan from federal lockup >>> the tuskegee airmen were the first african american flying unit in the u.s. military taking part in more than 1,500 missions between 1941 and '45 now a man believed to be one of the last surviving members is turning 100 years old. to celebrate his >>> "saturday night live's" losing big names it would appear deadline is reporting that kate mckinnon, pete davidson, kyle muni and ad bryant could leave the show after the current season nbc hasn't commented "snl's" 47th season finale airs tomorrow deadline reports that will be it for all four of those cast members. pete davidson started at "snl" in 2014 when he was 20 years old. at the time he was one of the youngest cast members ever lately the shpotlight has been n his and his new squeeze kim k. did you know they were dating? not a lot of people do they are ver

getting headlines out of this year's american society of clinical oncology conference meg tirrell has details. hi, meg. >> a couple movers as this world's largest cancer research conference drops thousands of data sets on cancer research ahead of the conference which starts next friday two up, two down to point your attention to pmv pharmaceuticals is the first one up more than 20% a rather small cap company, $600 million before the move today. this was an early stage study and multiple different kinds of tumors it does seem to be pleasing folks with the results in the after-hours. another one similarly is adicet bio. up 26% there also on a very early stage study, both of these companies are going to have updated data at the conference but moving positively in the after-hours. flip side we have meradi that appearing to disappoint folks down 15% the results did look good comparable to amgen's but might not last as long for mirati. down quite a bit in after-hours, almost 50%, a drug they have for melanoma ma and looks like the durability of response for the drug has been less for iovanc

where people are still hospitalized after the rebound of symptoms and that seems to be more rare >> meg tirrelled chains and super glue to look the door, he called five and hurt tee others. >> the heroic actions of the congregation are what they want you to hear about. >> watch byron brown on the people of his city and hugh his community is responding as we approach the bottom of theou hr and "the top of the news" on cnbc the highest level of safety you can earn? subaru. when it comes to longevity, who has the highest percentage of its vehicles still on the road after ten years? subaru. and when it comes to brand loyalty, who does jd power rank number one in the automotive industry for three consecutive years? subaru. it's easy to love a car you can trust. it's easy to love a subaru. ♪("i've been everywhere" by johnny cash) ♪ ♪i've traveled every road in this here land!♪ ♪i've been everywhere, man.♪ ♪i've been everywhere, man.♪ ♪of travel i've had my share, man.♪ ♪i've been everywhere.♪ ♪♪ ♪ ♪ i'm the latest hashtag challenge. and everyone on social media is trying me. i'm trending so hard that

meg tirrell with the very latest meg?rise nationally now cases more than 70,000 being reported every day, hosp hospitalizations have been rising week over week, still very close to pandemic lows in terms of the levels of hospitalizations deaths have ticked up just slightly, but are essentially flat still more than 300 americans dying every day from covid, but generally, kelly, what we hear from health officials in this wave is the level offy isser have disease relative to the number of cases is lower you're not seeing as many people being sent to the hospital or dying from covid as you might have expected in previous waves probably because of all of the immunity that's out there. one thing that is really driving things is this new sub variant known as ba.2.12.1 is estimated to be more transmissible than ba.2 and you can see the prevalence of this new variant nationally it's rising 43% across the country and it's not evenly distributed it is most prevalent in the northeast. two-thirds of cases in the new york region are no

where people are still hospitalized after the rebound of symptoms and that seems to be more rare >> meg tirrella southern california ape shooter first used in a southern california church, a shooter first used chains and super glue to look the door, he called five and hurt tee others. >> the heroic actions of the congregation are what they want you to hear about. >> byron brown on the people of his city and hugh his community is responding as we approach the bottom of the hour and "the top bottom of the hour and "the top of the news" on cnbc i have me ulcerative colitis. aily pill. because i won't let uc stop me from being me. zeposia can help people with uc achieve and maintain remission. and it's the first and only s1p receptor modulator approved for uc. don't take zeposia if you've had a heart attack, chest pain, stroke or mini-stroke, heart failure in the last 6 months, irregular or abnormal heartbeat not corrected by a pacemaker, if you have untreated severe breathing problems during your sleep, or if you take medicines called maois. zeposia may cause serious side effects including infecti

cnbc's meg tirrell covers science and medicine for us and she's on the top story at the bottom of thew, one of the leading hypothesize are adenovirus usually, they cause respiratory symptoms, but type 41 typically shows up in kids as diarrhea, vomiting, and ever while the cdc says there have been linked to liver issues with this type of virus before, it's always been in kids who are immuno compromised, and one of the most confounding parts of the situation now is at least among the earliest reporting cased in the u.s., all of the kids were previously healthy >> the cdc said today more than half of the patients under investigation had evidence of an adenovirus infection, and a report from the uk notes 72 pest of cases who were tested for it had adenovirus that compares to 18% who had sars-cov-2 there have been 360 cases or suspected cases reported from the u.s., uk, and europe scientists haven't ruled out covid, but it's not their leading hypothesis the cdc said other factors could be at play like environmental exposures, medications or other infections this is what disease detectives

shep. >> all right meg tirrell, good weekend.ale of the fake german heiress played out on netflix. now she is launching a new business plan from federal lockup >>> the tuskegee airmen were the first african american flying unit in the u.s. military taking part in more than 1,500 missions between 1941 and '45 now a man believed to be one of the last surviving members is turning 100 years old. turning 100 years old. to celebrate his big game today! everybody ready? alexa, ask buick to start my enclave. starting your buick enclave. i just love our new alexa. dad, it's a buick. i love that new alexa smell. it's a buick. we need snacks for the team. alexa, take us to the nearest grocery store. getting directions. alexa will get us there in no time. it's a buick. let's be real. don't make me turn this alexa around. oh my. it's painful. the buick enclave, with available alexa built in. ask “alexa, tell me more about buick suvs.” another crazy day? of course it is—you're with av a cio in 2022.uilt in. so what's on the agenda? morning sec

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. >> we're getting breaking news out of cdc meg tirrell has it meg? visors just voted in a favor of a booster for kids ages 5 to 11. this is for a booster at least five months after the primary series just for the pfizer vaccine at this point the moderna vaccine is under review by the fda for all kids under 18 you could see biontech up more than 6% on this news this is expected the cdc director now has to sign off and once she does so, the vaccinations among kids in this age group could begin within the next few days. we should note only about 30% of kids 5 to 11 have been vaccinated with the first two doses. sara. >> right so kids are now getting their boosters or at least the approval for the boosters an adults over 50 are supposed to get four shots is there decision of a fifth shot into the fall as the administration is looking at models that show we're going to get millions of cases again? >> yeah, absolutely. there is a lot of discussion about updating the vaccines to include protections against the omicron variant, whether that is a combination

this year is still not nearly as bad as previous years before the pandemiceporter: well, cnbc's meg tirrell covers science and medicine why is flu still around and spreading so quick >> the short answer is nobody knows exactly. there is speculation that as people have taken off masks and started gathering more could be contributing to flu come back in a bigger way also we all know flu is typically a winter virus ticking up in october and peaking between december and february but this year may have seen a peak in april. and the cdc tells us it is too soon to know if flu season has peaked yet and it is not evenly distributed. new mexico appears particularly hard hit right now dr. melissa martinez from university of new mexico health sciences. >> for the past two years its been covid, covid, covid and now suddenly we're seeing cases of influenza, which is pretty unusual because of what's been going on the last couple of years that we've seen lots of covid. but also it is unusual this late in the year to be seeing affluenza cases. >> reporter: she'd still recommend getting the flu shot even thi

the experts say this year is still not nearly as bad as previous years before the pandemic cnbc's meg tirrellscience and medicine for us. why is flu still around and spreading so quickly >> reporter: well, shep, the short answer is nobody knows exactly. there's of course speculation that as people have taken off masks and gathering more, that can be contributing to flu coming back. flu is a winter virus usually picking up in october and peaking between december and february this year's pattern may have seen a peak in april it's too soon to know if flu season has peaked yet. new mexico is particularly hard hit by flu right now we spoke with dr. melissa martine yez. >> for the past two years it's been covid, covid, covid, now suddenly we're seeing cases of influenza which is pretty unusual because of what's been going on in the last couple of years that we've seen lots of covid, but it's also unusual this late in the year to be seeing influenza cases. >> reporter: now she says she still recommends getting the flu shot even this late in the season because they're still seeing cases the cdc said

let's go to meg tirrell at cnbc. >> hi. well, thank you.ut this phenomenon we're seeing with paxlovid rebounds, which seems potentially rare. pfizer says they saw it about 2% in their clinical trial, but we hear a lot about it. and, you know, when people are testing positive again at day 10, i'm wondering, do you think there needs to be some federal guidance about isolation at that point, given that if people are testing positive again, they could potentially be contagious? how are you guys looking at this? dr. jha: yeah, so let me start maybe, and then i'll turn it over to rochelle to see if she has any further thoughts, or tony. but let me start by saying, meg, you're absolutely right that the clinical trials showed about 2% in the paxlovid group and about 1.5 percent in the placebo group. but that was with delta. and so the question is: is this more common with omicron? we're actually doing a lot of work right now to try to sort that out. we're talking to health systems, getting real-world experience data. but if you think about it: if y

our meg tirrell joins us do people expect this to spur more m & a, which has been very, very quiet latelylective hallelujah that went up among biotech investors this morning when they saw this pfizer news they have been waiting for deals like this, given the depressed valuations of biotech and given that pharmaceutical companies have a lot of patent expirations coming up and a lot of cash to spend. as raymond james pointed out, this is the third major pharma/biotech deal. two of the buyers of those deals were pfizer. the last one was pfizer's acquisition of arena for $6 billion in december and merck announced it's acceleron deal in september. but of course it has been such a rough go for biotech stocks. the xbi up almost 5% this is the index that tracks more mid and small cap names and that's up more than the ibb which has some of the larger biotechs in it over the course of a year, down 45% and really terribly performing over the last few weeks so it's been tough going you're seeing a couple of biotech stocks in particular outperform on speculation that they could be potential future tak

say this is still going to play a crucial role in the global fight to end the pandemic shep >> meg tirrell, thanks very much nearly a week into the search for accused murderer in alabama, cops still have no idea where he is the sheriff in lauderdale county said today the one-time inmate and now-former corrections officer who helped him escape are still out there. >> i have no clue. and, you know, as far as where they may be. that --' really the mange thing we need to know light now as far as a geographic lakz location. >> the sheriff is warning casey white is extreme dlarngs vicki white, corrections officer but no relation at all, says drn well, he says that she helped the made escape last friday. today, we learned detectives are looking loo into the whether the escapee may be connected to another case, the death of an ex-girlfriend 14 years ago our nbc affiliate, waff, reports in 2008, somebody shot her in the chest be a saw-off shotgun now, investigators ruled her death a suicide. the station reports the now-escaped inmate was there when she died. investigators say they are now reexamini

meg tirrell joins us for a look at which vaccine makers are able to target this virus hi, meg. >> hey is that there are already vaccines that exist for monkeypox, mainly because we had them for smallpox so a very different situation than we were in at the beginning of the covid pandemic. there's one vaccine cleared for smallpox and monkeypox made by a company called vivarian nordic there's another that's older and both of those stocks have had quite big runups over the last week as we've had news of more cases mounting we spoke with a ceo about the incoming inquiries they're getting from governments around the world about their vaccine. here's what he said. >> it's been crazy, to be honest we've been inundated with calls. we're trying to help them deal with the current situation we're ramping up production as we speak and hopefully we'll be able to provide doses. >> now, there are also a couple of drugs out there for smallpox and you can see that stock is up 30%. it's a very small market cap company and sold to emergent biotech solutions. that has run up but come back a bit. the main

biogen ceo is stepping down after the new alzheimer's drug let's get to meg tirrell with all of the details. >> well michelle, the ceo of biogen since january of 2017 is going to stay on as they conduct a search for his successor they were beginning the search today so he'll continue to be a ceo and member of the board as they do that and help with the transition but essentially this is being looked at as a re-set period for biogen after, as you said, it is really struggled with a roller coaster for the alzheimer's drug that got surprise approval in the middle of last year after the advisers with were against the drugs saying there weren't clear data showing that it worked and medicare gave a very narrow coverage opinion saying they would only pay for the drug for people in specific clinical trials that essentially doomed the drug to failure and the company saying today it is writing off $275 million in inventory basically eliminating the commercial infrastructure for the drug what is interesting, rest of the business is shrinking and biogen is betting in alzheimer's. it has another drug wi

meg tirrell has the latest meg?own to age 5 to 11. they can get the booster five months after the primary series. the fda has given the green light. we expect the cdc advisers to meet on thursday, talk about this, take a vote, and then the cdc director will make her recommendations. the fda pointing out that we know that efficacy of these vaccines starts to wane after two doses, especially in the omicron age, so they have been recommending third doses for all age groups parents of kids under 5, of course, they are still waiting for approval of the application maybe in june. >> i was going to ask you that it's been delayed how many times now? >> it's hard to count. i think we were expecting it around the same time as 5 to 11, at the end of last year. now we're in may, we're expecting it in june i think there's not expected to be more delays, but we've been in this boat before. >> keep us posted. meg, thank you. >>> quick programming note late today on "closing bell" we have an exclusive interview with former treasury

our meg tirrell has the latest for us >> hey, morgan pfizer beating for the uarter, reiterating the full-yearenue of $98 billion to $102 billion. it lowered guidance due to foreign exchange impacts, as well as some changes in accounting, but reiterating that full-year forecast. >> a lot of that coming from the covid business paxlovid, and the vaccine comop irnaty analysts trying to parse it out, as we try to understand the path of this pandemic, and ordering patterns another huge question for pfizer will be m&a plans, that as implications for the entire biotech sector the etf tracks more -- that's been incredibly beaten down over the last year, now down more than 40%, m&a is something invest offers will hopefully bring some of those values back up pfizer has said it plans to bring in $25 bill onby 2030 through business development, so expecting them to be very active with a lot of the covid revenue that has come in from their vaccine and antiviral. david? >> meg, thank you. >>> after the break right here at the milkin conference i'll have a conversation with michael arougheti. back in two min

meg tirrell has the latest hey. >> a beat. earnings at $1.62 on adjusted basis.ersus the share of $1.47. analysts looking for $23.9 billion. the company stating the full year revenue forecast to $102 billion in revenue despite impacts from foreign exchange. guidance lowering to 6.45. effected by a change in the accounting for r&d the product lines as they are reiterating the covid vaccines for the quarter, it looks like a big beat for the covid vaccine more than $13 billion. analysts were looking for $10.5 billion. a miss on paxlovid $1.9 billion is what the street was looking for. a slight miss on the breast cancer drug. you are seeing pfizer down at 3% in the early trading we will have albert bourla at 1 1:00 today guys >> meg, thanks we'll take it at 1:00. thank you for bringing us up to date i hope pfizer doesn't benefit from vaccines for covid for all eternity it would be bad for pfizer, but maybe there will come a day, meg. >>> coming up, australia's central bank raising interest rates there by more than expected could that be the fed plan for this week? we

meg tirrell has that news and more hey, meg >> pfizer is saying the vaccine for kids under 5 met thee clinical trial they plan to file the three-dose vaccine with the fda this week they had preliminary efficacy data 80% protection was provided by three doses against symptomatic covid in the period when omicron was the circulating variant. the profile was similar to the placebo. the 80% number is based on ten cases in the trial they need 21to call it final that could be updated. based on this, bringing to the fda. pfizer was filing with two doses in february. they decided it wasn't strong enough in the age of oimmicron d added the third dose you see the comparison with pfizer and moderna moderna under review with the ds this will go to the fda and head to the committee meetings in june a lot of parents waiting a long time still no vaccine for kids under 5. joe. >> meg, can i ask a question there has been so many twists with this. the reason this is not approved yet is not because of safety, but because of efficacy. the testing was while omicron was out and it made it different from th