is a missedlts, it opportunity both for the research community and especially for patients who would benefit by enrolling and maybe giving them access to something that could've been much work targeted for their needs. we have to work hard on this. the other point is reimbursement. if we are going to see these types of events is finding their way into the standard of care, who his handclear and as a challenge with many of the new developments being sufficiently new and have not gone through the discussions. some of the new drugs are expensive. >> there was a piece on "60 minutes" about the high cost of cancer drugs. it made a scene it was random how much a cancer drug cost, is it? what determines the cost? andhe fundamental question that is an important issue is to think about what drives the cost . at the end of the day, for us to incentivize innovation and address major needs especially in pediatric cancers or rare cancers, etc., we have to do a much better job in reducing the extraordinarily high rate of failure in cancer drug development and testing. for every 20 drugs that enter