mnd is caused by the death of the nerves that carry brain to's muscles. become damaged, the muscles they control we can and waste. it dramatically reduces life expectancy and most t not all cases. here is stephen hawking, the world's best-known physicist. he was given a life expectancy of just two years but lived for 55 after his diagnosis. the research was carried out in part by the neuroscience institute at sheffield university in england. here's the director talking about the discoveries. >> 2% of patients with mnd have a slight fault in this gene. what t therapy does, it has to be injected by a lumbar puncture into the spinal fluid. and it lowers the level of the protein and the toxic effects to motor neurons that arise from the protein. >> so, that was the professor shaw talking about the drug. now let's take a look at the breakdown of how that drug actually works in the body. it is complicated but i will do my best to explain. instructions for building sod1 are locked inside dna in the cell's nuclear's. then, they are carried by a short strand of ge

this funding will notjust be focused on mnd, it will notjust be focused on mnd, it will be tightly fundedhe academic, what is called the basic science, the discovery science, into drug development now. we have got an unprecedented number of drug companies which are actually developing an interest in mnd and running clinical trials. one of the key things of this money is that we will be able to use it to make the uk the best place the drug companies around the world to come and run these trials. is around the world to come and run these trials-— these trials. is there any sign, we have had a _ these trials. is there any sign, we have had a number— these trials. is there any sign, we have had a number of— these trials. is there any sign, we have had a number of high - these trials. is there any sign, we have had a number of high profile cases that viewers of this programme will know about, rob burrows, dottie weir as well, do you have any date of suggesting that mnd i5 weir as well, do you have any date of suggesting that mnd is becoming more common? or is itjust much more visible now? it i

mnd is a horrific disease.ou to doddie and obviously steven darby too, and we got together for a chat. since then, how are you doing and how is life at the moment? a lot has happened since i met the guys for the first time. i could walk and talk with the guys when i met them in edinburgh. i declined a lot throughout lockdown. i am now settled down and not got any worse for 18 months now and that is called a plateau. to be honest, i didn't think i would be here now. it's been quite a while since you've seen doddie. what was it like to see him again today? hi, dodd, not seen you for a while. how have you been, you big giraffe? remember when we all met in scotland? what a day that was. and it started something i think that's really quite special. how have you been since then? hi, ed. how the devil are you? welcome to the dream team. yeah. ed, obviously, this is the first time that we've got you together with the guys. i know it's really early days for you. how important is it for you to see the, i guess, the menta

so mnd — also known as amyotrophic—lateral sclerosis — is caused by the death of the nerves that carrylived for a further 55, after his diagnosis. the research was carried out, in part, by the neuroscience institute at sheffield university in england — here's director professor dame pamela shaw talking about their discoveries. 2% of patients with mnd have a slight fault in this sod1 gene, and what the therapy does, it has to be injected to be at a lumbar puncture into the spinalfluid, and it lowers the level of the sod1 protein and the toxic effects that arise from that protein. so that was professor dame pamela shaw talking about the drug tofersen. now let's look at a breakdown of how the drug works in the body. first of all — instructions for building sod1 are locked inside dna in the cell's nucleus. then they are carried by a short strand of genetic code, messenger rna this creates the toxic protein. the drug then kills the messenger and — crucially — prevents the creation of toxic proteins. but if the treatment works in only 2% of patients why has it been described as a breakthroug

we could see some ponding on the roadways so maybe some clogged mnd ithnorth bay see the posbity of isolated problems. in the middle to latter half wkd highs into the 90's. we are excited about this mainly beneficial rain. stephanie: as far as the three-day period, tomorrow is the most moisture? lisa: yes. stephanie: a nine-year-old boy left el salvador to join his parents in san rafael. how his experience is an inspiring story to help others. what's it like having xfinity internet with supersonic wifi? it's fast... like beyond-gig-speed fast. yeaaaaaaaaay!!! withe power to connectandwidth, hundds get the xfinity supersonic bundle with unlimited gig speed internet, wifi equipment included and a free 4k streaming box. all for $50 a month with a 2 year internet rate guarantee and no annual contract when you add xfinity mobile with unlimited data. switch today! i believe prop 27 is the right thing to do. i had experienced being in shelters at a young age. having nothing. prostituting. we don't choose this life. i never knew what safe was until i came to city of refugee. people that's coming thr

in an ideal world i would have played ten minutes, but because of mnd symptoms, bits and pieces, it's month in the august heat. so, forformer players, is this any easier? i would say honestly this is harder. because you think it's still inside you to play the game and take the contact, but it's tough, it's tough, obviously its class being back at kingsholm with all the lads again. it's something i thought i'd never do personally. i said to my wife, i promised her i'd never play rugby again. then obviously as the years go by, billy asked me, obviously the reasons around ed as well, it's one of them where you kind of have to do and want to. i think it was possibly one of the hardest things i've ever done but still worth it, the bike ride. some of us have still got no feeling in our feet, i've still got two toes. it's obviously tragic and we've just got to be around him, support him, support his family, things like this raising awareness as well for this disease it is really important and obviously everyone being here today shows that as well, the support. there are world cup winners, fo

accountability for anyone who acts inappropriately ,but they don't want politicians jumping to themck the mnd throwing under the bus. we shoulend back the men andin women in blue . they were the only thing that stand between you and your family. these criminals like you seenig tonight in this rampagane acrosc itthe city of memphis and in fact, the people who are most harmed by this crime wave areie. likely to be minorities. memphimemphis is a majoritylook african-american city. look at what they've had t a toe deal with, not just in the lastd few days, but in monthsears o and years of rising crime, the same as the case in so manya cities across america. s americthe democratic left has. african-americans where crime is rising inn th their neighborhoods. that maneir neorhoods. that kila fletcher was apparently terrorizing his own community, the apartment building he lived in. where were the police officers? black, white, latino or any other race to protect those citizens? r anythey deserve better from their elected leaders. >> and meanwhile, we havrom thee consent decrees that t the justice dep

you can watch rob burrow: living with mnd at 7pm on tuesday 18th october on bbc two and iplayer.ry? no! it is as much about _ she says. does rob need to worry? no! it is as much about the - she says. does rob need to worry? no! it is as much about the family. no! it is as much about the family and the support — no! it is as much about the family and the support team _ no! it is as much about the family and the support team and - no! it is as much about the family and the support team and the - no! it is as much about the family i and the support team and the family and the support team and the family and community is helping people as it is about rob himself up like it is about love, how much they love him and he loves them, love from the rugby league community and people who have met them. that support has been so important.— been so important. more to come on that next month. _ been so important. more to come on that next month. it _ been so important. more to come on that next month. it will— been so important. more to come on that next month. it will be _ been so important. m

maybe it is rich mnds or sunset or areas historically taxis haven't been seen to provide service. there are avenues to market and promote. i think those are the biggest and i did have slides to show some of the data snapshots of the data. not the uber data or third party data but thought it might be helpful to show screen captures of what we are tracking and looking at and what we will be looking at but that is a huge one. in addition, obviously in addition to supporting the drivers which you acknowledge is a given and baseline. this data is-will be very helpful for us and the data isn't flowing the other way. we are getting data in o the mta side of the house. not sure any separate arrangements between the taxi industry and any other third party entities, but mta is receiving data. i wonder if we can pivot. would you like to see some of the data we collect and what that looks like? would that be helpful or not? >> i don't know what it-the data i was going to ask about, i don't know if you have it is we have fare comparison data between the tnc and the cabs. >> we don't have that

maybe it is rich mnds or sunset or areas historically taxis haven't been seen to provide service. there are avenues to market and promote. i think those are the biggest and i did have slides to show some of the data snapshots of the data. not the uber data or third party data but thought it might be helpful to show screen captures of what we are tracking and looking at and what we will be looking at but that is a huge one. in addition, obviously in addition to supporting the drivers which you acknowledge is a given and baseline. this data is-will be very helpful for us and the data isn't flowing the other way. we are getting data in o the mta side of the house. not sure any separate arrangements between the taxi industry and any other third party entities, but mta is receiving data. i wonder if we can pivot. would you like to see some of the data we collect and what that looks like? would that be helpful or not? >> i don't know what it-the data i was going to ask about, i don't know if you have it is we have fare comparison data between the tnc and the cabs. >> we don't have that