please welcome siddhartha mukherjee. (cheers and applause) doctor, thank you so much for joining me. >> my pleasure. >> stephen: as i said your book is a pulitzer prize-winning, the em error of all maladies, a biography of cancer. i know is about cancer but let's keep it light, okay. when i said over there about cancer getting hit by a bus, why that makes sense to me is that cancer feels like an alien living thing in a body. it's doing what it wants. is it like another living thing in you? >> in some ways it is, but what's really, really tricky. and this was a realization that sent a real chill up the spines of all the biologists and scientists, what is really tricky is that the very genes that cause your normal sells to grow f you corrupt those genes that is what causes cancer to grow. the very genes that cause your embryo to grow, if you corrupt those genes, if those genes stop working properly that is what make cancer cells grows, it is not completely outside your body, it comes from the genetic material that is part