one such product works by regulating neurotransmitters. namely noradrenaline and serotonin, which are both neurotransmitters which affect appetite. and by increasing the level of these neurotransmitters in the brain, the appetite can be effectively suppressed. patients on this program have been able to lose about five to 10% of their total body weight, and maintain it. ralph cygan: we know now that losing modest amounts of weight-- for most patients, about 10% of total body weight-- can have a profoundly positive effect on health risks of obesity. so from the medical perspective, modest weight loss and maintenance is really the goal that we try to get our patients in tune with. by studying people who have lost weight, and maintained that loss for five years or more, researchers are beginning to document factors that promote success. ralph cygan: we've learned a couple of, i think, very good lessons from this study. first and foremost, the patients accept responsibility. they don't blame anybody else. it's their job and their responsibility