andrew solomon chronicled his own battle with depression in his 2001 award winning book, the noonday demon, an atlas of depression. he is also a lecturer in psychiatry and joins me this evening to share his story an insight into the disease. also joining me today are remarkable group of scientists, peter whybrow is director of the jaind an institute for neuroscience and human behavior and a professor of the david give never school of medicine at ucla, goodwin is clinical professor of psychiatry as george washington university and helen mayberg is professor of psychiatry and neurology in radiology and a chair in psychiatry and nea therapeutics. >> and eric kandel, he is a nobel laureate, professor at columbia university and howard hughes medical investigator and begin as usual, with dr. kandel. >> thank you, charlie. >> rose: what should we be doing? >> we should think about how we got to where we are, and you began that very wonderfully at the beginning of the century the founder of modern psychiatry divided the major psychiatric illnesses, the psychotic illnesses into two groups, disorder