oxford astrazeneca trial in children. ., oxford astrazeneca trial in children-— oxford astrazeneca trialhildren. you mentioned that by the time we get around _ children. you mentioned that by the time we get around to _ children. you mentioned that by the time we get around to vaccinating i time we get around to vaccinating younger age groups there may be other vaccines in play, anyway. and let's talk about moderna being rolled out in the uk for the first time today in wales. what do we know about this particular vaccine, its efficacy and how it fits into the wider vaccination programme? yeah, well, it's actually _ wider vaccination programme? yeah, well, it's actually very, _ wider vaccination programme? yeah, well, it's actually very, very - well, it's actually very, very similar to the pfizer vaccine. it's produced in roughly the same way and it works in exactly the same way as the pfizer vaccine. and when you look at the results of the phase three trials, it's very difficult, until you see the title on the top of the paper, to work out which data comes from witch trials, the results

first, what is the risk with oxford—astrazeneca? serious illness with covid is weighed against potential harms from blood clots. the official advice is for anyone who has had a firstjab and four days or more after that gets severe headaches, blurred vision or certain other symptoms, should contact a medical professional. a committee of europe's regulator, known as pr ac, to this conclusion. we know the benefits of the astrazeneca vaccine have been established. it prevents covid disease, it prevents hospitalisation and it prevents mortality. so in that respect prac feels that the overall benefits outweigh the risks. so will it delay the vaccine rollout? health officials say even with under 30s given a choice of alternative jabs, they're still course to offer all adults a first dose by the end ofjuly. so the road map should stay the same. although it does depend on supplies currently promised. of the vaccines currently in use, the government ordered 100 million doses of oxford—astrazeneca. though the rollout will slow down this month

more now on the pause in the trial of the oxford astrazeneca vaccine on children in this report from walsh. there you go — all done. nearly 300 children aged six to 17 are taking part in the astrazeneca vaccine trial in england, which began in february. oxford university said there'd been no blood clots in the volunteers but, out of an abundance of caution, it had stopped vaccinations, pending the outcome of the safety review in adults. more than 18 million people in the uk have received the astrazeneca vaccine. the mhra said last week there'd been 30 rare cases of blood clots, including seven deaths. so it's nice to be able to see that the area is sterile. including seven deaths. the prime minister, visiting an astrazeneca plant in macclesfield, once again gave his firm support for the vaccine. the best thing people should do is look at what the mhra say, our independent regulator — that's why we have them, that's why they're independent. and their advice to people is to, you know, keep going out there, get yourjab, get your second jab. as a precautionary measure, the mhra updated i

so, if anybody is waiting to get their first vaccination, which may be the oxford astrazeneca or indeedcoming on stream all of the time, should i hold out for one of those? these are the questions that people will be asking. what is your advice to those people today, sir kent? well, i can only say that the relations of mine have been going to get their vaccinations and i have no concerns about them getting the astrazeneca vaccine. i'm far more concerned about them not getting a vaccine and catching the infection itself, which is a totally different risk profile to anything that might emerge from the latest analysis of the astrazeneca vaccine. he is the former chief executive of the mhra, and the briefing involving the mhra, and the briefing involving the mhra, and the briefing involving the mhra is due here at three o'clock this afternoon. that will be taking place at the same time as a briefing from the ema. it is going to give its assessment later on this afternoon of the astrazeneca vaccine. anna holligan has more from the ema's headquarters in amsterdam. so we are expecting updates

first, what is the risk with oxford—astrazeneca?e, as the potential for serious illness with covid is weighed against potential harms from blood clots. the official advice is that anyone who has had a firstjab and four days or more after that gets severe headaches, blurred vision or certain other symptoms, should contact a medical professional. a committee of europe's regulator, known as prac, drew this conclusion. we know the benefits of the astrazeneca vaccine have been established. it prevents covid disease, it prevents hospitalisation and it prevents mortality. so in that respect, prac feels that the overall benefits outweigh the risks. so will it delay the vaccine roll—out? health officials say even with under—30s given a choice of alternative jabs, they're still on course to offer all adults a first dose by the end ofjuly. so the road map should stay the same. although it does depend on supplies currently promised. of the vaccines currently in use, the government ordered 100 million doses from oxford—astrazeneca. though the ro

so, from now on, people aged between 18 and 29 will be offered an alternative to the oxford—astrazenecat those who've already had a first dose of the astrazeneca vaccine should go ahead and get the second. pregnant women and people with certain blood disorders should consult a doctorfor advice. and the medical regulator has insisted that the benefits of taking the astrazeneca vaccine still far outweigh the risks for the vast majority of people. 0ur medical editor, fergus walsh, looks at the factors behind today's changes. turn up, get yourjab. the message remains the same. but in future, for the first time, the covid vaccine you receive will depend on your age. that's because evidence is emerging of a link between the oxford—astrazeneca vaccine and very rare blood clots. the uk regulator, the mhra, said up to the end of march there have been 79 cases of rare clots with low platelets following a first dose of the astrazeneca vaccine. 19 people have died. that's out of 20 million who received the jab. that's one rare clot in every 250,000 vaccinations. these monitoring systems are now det

- oxford astrazeneca vaccine? yeah, this is a very _ oxford astrazeneca vaccine?a very challenging situation. because we do have an identified, very rare but serious adverse events. and i think what is happening now is good, that people are being informed, and communication has been happening right from the very beginning when a suspicion was a rose. so that's a good thing. in terms of what people should do about this, they should still have the vaccine but they need to be informed and they need to have a choice of whether to have it or not —— suspicion arose. there will be people who become more hesitant because of this particular risk, and they need to have an opportunity to have a discussion with a health professional and way of those risk carefully because there is a risk of not vaccinating as well. you specialise — not vaccinating as well. you specialise in _ not vaccinating as well. you specialise in vaccine - not vaccinating as well. you specialise in vaccine hesitancy. there's this idea of vaccine competence, potentially being dented. how do you counter th

first, what is the risk with oxford—astrazeneca? lower the older you are, as the potential for serious illness with covid is weighed against possible harms from blood clots. some medication, including the contraceptive pill, also has a very small blood clot risk. anyone who has had a firstjab and four days or more after that gets severe headaches, blurred vision or certain other symptoms should contact a medical professional. a committee of europe's regulator, known as prac, drew this conclusion. we know the benefits of the astrazeneca vaccine have been established. it prevents covid disease, it prevents hospitalisation and it prevents mortality. so in that respect prac feels that the overall benefits outweigh the risks. so will it delay the vaccine rollout? today a newjab was delivered for the first time in wales and scotland, made by the us company moderna. it is set to be offered elsewhere in the uk from next week. health officials say even with under 30s given a choice of alternative jabs, they're still on course to offer all ad

if tomorrow the us never authorised the astrazeneca oxford vaccine and shelved the johnson astrazenecashelved thejohnson & astrazeneca oxford vaccine and shelved the johnson & johnson vaccine, shelved thejohnson &johnson vaccine, it may shelved the johnson & johnson vaccine, it may not have that much impact on the us programme because they have other options, they have procured so much of the mrna vaccines and the particle vaccine may still be there. but the problem when you look at sub—saharan africa and latin america, they are all adenovirus vector vaccines, and if somebody signals a problem oran if somebody signals a problem or an alarm, that could have a devastating effect on the ability of africa and latin america to fight this pandemic. so it is so important how we operate and proceed, not only thinking about the safety of the american people but thinking about the world. us presidentjoe biden has urged russian president vladimir putin to ease tensions on the ukrainian border and suggested they hold their first summit. this comes as tensions rise over russia's military build—up n

the oxford—astrazeneca coronavirus vaccine trial on children and teenagers is temporarily paused tonight as the uk regulator investigates whether there is a possible link with rare blood clots in adults. oxford university say they won't carry out more jabs on younger people "out of an abundance of caution". more data is due to be published in the coming days — the world health organization says the vaccine�*s benefit largely outweighs the risk. forthe time being, there is no evidence that the benefit risk assessment for the vaccine needs to be changed. the argument continues over so—called covid passports — and what they might be needed for. the disappearance of 19 —year—old richard okorogheye — a body is about to be formally identified. fresh calls to deport members of a notorious rochdale grooming gang after one of the men was spotted in the town where he abused young girls more than a decade ago. also coming up... tributes to the actor paul ritter — best known for his role in �*friday night dinner�* — who's died of a brain tumour at the age of 5a. a trial of the oxford—astrazeneca cor

a trial of the oxford—astrazeneca vaccine on children is suspended in the uk, while the country's regulatorestigates possible links to rare blood clots in adults. russian police detain supporters ofjailed kremlin critic, alexei navalny, amid reports he is suffering from a respiratory illness. one is fun — why so many of china's parents are limiting themselves to a single child, despite now being allowed to have more. translation: for me, - it's already hard to raise this one. it feels better to put all your energy into one child, or we might feel guilty that we can't properly take care of many. hello and welcome if you're watching in the uk or around the world. it's day seven in the trial of former police officer derek chauvin in minneapolis, the man accused of killing george floyd by kneeling on his neck in a case that triggered worldwide protests over racial injustice. today, we've been hearing more evidence from former colleagues of derek chauvin in the police department, with a particular focus on the training that officers receive. our correspondent larry madowo has been following the

i have had my first dose of the oxford astrazeneca vaccine and am 0xford astrazeneca vaccine and am lookingn't have the vaccine because you are worried about this, you are actually in a more at risk group. you are more likely to be dead at christmas than if you had the vaccine. so please do what the prime minister says and continue to go in for your second dose. i prime minister says and continue to go in for your second dose.- go in for your second dose. i think it's worth clarifying _ go in for your second dose. i think it's worth clarifying exactly - go in for your second dose. i think it's worth clarifying exactly what i it's worth clarifying exactly what you mean when you talk about younger people. you mean when you talk about younger --eole. . ., �* ~ ., you mean when you talk about younger ”eole. ., ., �* 4' ., ., people. yeah, we don't know for certain what _ people. yeah, we don't know for certain what the _ people. yeah, we don't know for certain what the age _ people. yeah, we don't know for certain what the age group - people. yeah, we don't know for certain what the age group i

this and the oxford astrazeneca “ab? this is the and the oxford astrazeneca jab?e pfizer or madonna —— modern jab instead. we are still on track to offer the vaccine to all adults by the end ofjuly, but it does mean that we are taking this in the safest way possible to save as many lives as possible, as quickly as possible. that is the goal and i'm very grateful to these world class regulators who can spot this extremely rare events. i class regulators who can spot this extremely rare events.— class regulators who can spot this extremely rare events. i wonder if ou can extremely rare events. i wonder if you can take _ extremely rare events. i wonder if you can take us— extremely rare events. i wonder if you can take us through _ extremely rare events. i wonder if you can take us through some i extremely rare events. i wonder if you can take us through some of. extremely rare events. i wonder if i you can take us through some of the practicalities. you said those under 30 will be offered the opportunity to have an alternative vaccine. how will it work in practice?

also tonight: the health secretary insists the oxford—astrazeneca vaccine remains safe — with the riskd clot the same as going on a long haulflight. the chancellor, rishi sunak, releases text messages he sent to david cameron after the former prime minister asked the government to help a finance company he was involved with. the mother of a 19—year—old student found dead in essex says his disappearance wasn't taken seriously enough by police. if richard was a different colour, if he wasn't black, i know it's hard to say that, but the discrimination was quite obvious. and heading back to some sort of normal — why some are finding rolling back restrictions daunting after a year of lockdown. and coming up in the sport on the bbc news channel: the masters is underway at augusta, but it's been frustrating first round for rory mcilroy. he finished with a 4 over par 76. good evening. police in northern ireland have used water cannon tonight as more petrol bombs and fireworks were thrown on the seventh night of violence on the streets of belfast. the renewed unrest comes despite a plea for cal

if tomorrow the us never authorised the astrazeneca oxford vaccine and shelved the johnson astrazenecaved thejohnson & astrazeneca oxford vaccine and shelved the johnson & johnson vaccine, shelved thejohnson &johnson vaccine, it may shelved the johnson & johnson vaccine, it may not have that much impact on the us programme because there are other options, they have procured so much of the two mra vaccines in abundance. but the problem is that when you look at sub—saharan africa, latin america, they are all adenovirus vector vaccines. if somebody signals a problem or sounds the alarm, that could have a really devastating effect on the ability of africa and latin america to fight the pandemic. so it's so important how we operate and proceed, not only thinking about the safety of the american people but thinking about the world. professor, i know you know your subject through and through, but speaking in laypersons terms, if someone says they are worried about the vaccine, any vaccine, and worried about the risks of covid, what would you advise? h0 risks of covid, what would you advise? .

_ confidently receive the oxford astrazeneca vaccine _ confidently receive the oxford astrazeneca vaccine second question i- astrazeneca vaccine if it is offered | to me. the second question i want astrazeneca vaccine if it is offered i to me. the second question i want to ask is— to me. the second question i want to ask is that _ to me. the second question i want to ask is that europe _ to me. the second question i want to ask is that europe remains— to me. the second question i want to ask is that europe remains one - to me. the second question i want to ask is that europe remains one of- ask is that europe remains one of the most — ask is that europe remains one of the most vaccine _ ask is that europe remains one of the most vaccine sceptical- ask is that europe remains one of. the most vaccine sceptical continent in the _ the most vaccine sceptical continent in the world — the most vaccine sceptical continent in the world. will— the most vaccine sceptical continent in the world. will allowing _ the most vaccine sceptical continent in the world. will allowing a - in the world. will al

not suggest blood clots are caused _ evidence did not suggest blood clots are caused by the oxford — astrazenecat there were people... it is a novel virus. _ there were people... it is a novel virus, people are having to completely reappraise —— constantly reappraise — completely reappraise —— constantly reappraise. there is a degree more of caution, — reappraise. there is a degree more of caution, on the continent, as in other— of caution, on the continent, as in other countries, but it looks like it appears— other countries, but it looks like it appears to be age—related, so this astrazeneca vaccine is the workhorse of the programme and other ones are _ workhorse of the programme and other ones are coming on stream ofjust today, _ ones are coming on stream ofjust today, as — ones are coming on stream ofjust today, as you say, a care worker in wales— today, as you say, a care worker in wales got— today, as you say, a care worker in wales got the first moderna vaccine, so we _ wales got the first moderna vaccine, so we are _ wales got the first moderna vaccine, so we are seeing gradually, this i

here in the uk, a trial of the oxford—astrazeneca vaccine on children has been paused while scientistsossible link with rare blood clots in adults. the university of oxford has told the bbc that there are no safety concerns with the trial itself, but its scientists were waiting for further information. the prime minister boris johnson has urged people to get their vaccination when invited. our medical editor fergus walsh reports. nearly 300 children aged 6—17 are taking part in the astrazeneca vaccine trial in england which began in february. oxford university said there had been no blood clots in the volunteers, but out of an abundance of caution, it had stopped vaccinations, pending the outcome of the safety review in adults. more than 18 million people in the uk have received the astrazeneca vaccine. the mhra said last week there had been 30 rare cases of blood clots including seven deaths. the prime minister, visiting an astrazeneca plant in macclesfield, once again gave his firm support for the vaccine. the best thing people should do is look at what the mhra say, our independent

the headlines: the uk's medicines regulator, says the oxford astrazeneca vaccine is �*safe'.re blood clots. the european medicines agency says blood clots should be listed as a very rare side effect. the british government says it will provide targeted help to the hundreds of thousands of hong kong citizens expected to move to the uk using a special visa. the chinese government has introduced a security law there which restricts longstanding democratic freedoms. at the murder trial of the former police officer, derek chauvin — the prosecution has reversed part of its evidence over the words uttered by george floyd. after initially accepting mr floyd had said "i ate too many drugs" — they now believe he actually said "i ain't done no drugs. now on bbc news, it's hardtalk with stephen sackur.

that's because evidence is emerging of a link between the oxford—astrazeneca vaccine and very rare bloode uk regulator, the mhra, said up to the end of march, there have been 79 cases of rare clots with low platelets following a first dose of the astrazeneca vaccine. 19 people have died. that's out of 20 million who received the jab. that's one rare clot in every 250,000 vaccinations. these monitoring systems are now detecting a potential side effect of the covid—19 vaccine astrazeneca in an extremely small number of people. the evidence is firming up. the balance of benefits and known risks of the vaccine is still very favourable for the vast majority of people. very few adults under 30 have died from covid, so that changes the risk—benefit balance from getting a vaccine. it's thought younger adults are at higher risk from clots after the astrazeneca jab, about one in every 100,000 doses. so they will be offered a different vaccine when their time comes. are you worried that this change of course might damage vaccine confidence, especially in the young? these are really carefully consid

the oxford—astrazeneca coronavirus vaccine trial on children and teenagers has been paused while thek regulator investigates whether there's a possible link with rare blood clots in adults. experts say there are no safety concerns. the us has hailed the start of talks in vienna which aim to revive the iran nuclear deal as a welcome and constructive step. the two sides are not meeting directly, but talking hello and welcome to our look ahead to what the the papers will be bringing us tomorrow. with me are rosamund urwin, senior reporter of the sunday times and broadcaster and author, john kampfner. tomorrow's front pages. starting with. the cost of coming home from a foreign holiday could be up to £420 per person, reports metro, as a result of needing to pay for covid tests, with a warning from easyjet that summer breaks could be for the wealthy only. but the daily mail says affordable holidays could be on the horizon within weeks, as it reports that the prime minister has asked officials to look into using quick and cheap lateral flow tests, rather than costly pcr tests for traveller

few weeks _ oxford—astrazeneca vaccine a few weeks ago.our of having the vaccine and i encourage everybody, like myself— vaccine and i encourage everybody, like myself and my family, to go for their second or indeed their first astrazeneca vaccine when called. were _ astrazeneca vaccine when called. were both — astrazeneca vaccine when called. were both referring to age. professor paul hunter, tell us about the significance of age. we are not currently vaccinating people not at risk, for example, below 50. it is risk, for example, below 50. it is very difficult _ risk, for example, below 50. it is very difficult because we have not seen _ very difficult because we have not seen reports of the case series, the number— seen reports of the case series, the number of— seen reports of the case series, the number of people who have had service — number of people who have had service venous sinus thrombosis definitively but we are certainly hearing — definitively but we are certainly hearing that primarily is it something happening in younger peo

a new malaria vaccine developed by the team behind the oxford—astrazeneca jab has proved to be 77% effectiverly trials. and at 5:45, anna smith gives her take on the best and worst of the week's film and dvd releases. that's in the film review. good afternoon and welcome to bbc news. there are calls for a full public inquiry after 39 former subpostmasters who were convicted of theft and false accounting because of a defective post office accounting system were cleared by the court of appeal. it's the uk's most widespread miscarriage ofjustice. some had gone to prison, and many sawjobs, marriages and reputations ruined after being wrongly accused of financial irregularities. the court heard that a computer software system called horizon had problems from the beginning of its installation. the post office has apologised for the impact the scandal has had on the men and women who were convicted. katie prescott reports. unsure whether to laugh or cry. after year of being labelled criminals, some shunned by their communities, even imprisoned, these former postma sters saw their these former postm

the headlines: the uk's medicines regulator says the oxford astrazeneca vaccine is safe.the european medicines agency has said any blood clots should be listed as a very rare side effect. myanmar�*s ambassador to the uk says his embassy in london has been taken over by the burmes military and he's been locked out. kyaw zwarminn, who opposed february's military takeover in myanmar, says he's been the victim of a kind of coup in the middle of london. indirect talks between washington and tehran have continued in vienna. the state department has said america is prepared to remove sanctions on iran, in order to resume compliance with the 2015 iran nuclear deal. president trump pulled the us out of the agreement in 2018. ever since the first reports suggesting a link between blood clots and the astrazeneca vaccine, there have been

that's because evidence is emerging of a link between the oxford—astrazeneca vaccine and very rare bloode uk regulator, the mhra, said up to the end of march, there have been 79 cases of rare clots with low platelets following a first dose of the astrazeneca vaccine. 19 people have died. that's out of 20 million who received the jab. that's one rare clot in every 250,000 vaccinations. these monitoring systems are now detecting a potential side effect of the covid—19 vaccine astrazeneca in an extremely small number of people. the evidence is firming up. the balance of benefits and known risks of the vaccine is still very favourable for the vast majority of people. very few adults under 30 have died from covid, so that changes the risk—benefit balance from getting a vaccine. it's thought younger adults are at higher risk from clots after the astrazeneca jab, about one in every 100,000 doses. so they will be offered a different vaccine when their time comes. are you worried that this change of course might damage vaccine confidence, especially in the young? these are really carefully consid

stories began to emerge both in the uk and in europe, in particular about the astrazeneca, the oxford astrazenecaaccine and when they are reputable reports based on the safety data, the safety monitoring data we have a duty to report that. but also to set it into context. i really think the viewers and listeners and readers don't expect our reporting to simply be black and white. there are shades there. and it's about presenting the balance of the risk against the benefits. are you worried at all that some viewers feel that the bbc might be feeding vaccine hesitancy? well, i hope not. i can remember a couple of weeks ago it was on the six and ten o'clock news when the sort of, definitive or the latest raft of reports came out about the link between clots and between the vaccine. and the vaccine advisory group suggested that people under 30 here get an alternative jab. and it was important to present any risk within context. i knew that that's what was coming out. and that morning i contacted a professor at the wynton group in cambridge who is absolute world expert on communicating at risk. and ac

the ema had recorded 169 cases among the approximately 31t million people who've receive the oxford astrazenecand it's now up to the individual governments to decide, they said, they have to make up their minds who they'd like to vaccinate and with what kind of vaccine. and as we've already seen, the uk has already decided to offer people under the age of 30 and alternative if it exists, and they're not in the high risk factor category. european health ministers are holding an informal or virtual meeting now to decide whether there needs to be some kind of eu wide coordinated response to this. because as we've been hearing, there is this risk it could undermine public confidence and the vaccines might be out of the pandemic, but it depends on people it having the confidence to take them so we can return to a normal kind of society. confidence has already been undermined in the astrazeneca vaccine, so how do you think today's ruling will affect that?— ruling will affect that? people are lookin: for ruling will affect that? people are looking for clarity, _ ruling will affect that? people are loo

for nearly all age groups, the benefits of the oxford—astrazeneca vaccine far outweigh any potential, for every 100,000 vaccinated, 1a icu admissions would be prevented. at the same time, there would be a 0.2 or one in 500,000 risk of a rare serious plot. for people in their 20s, it's a fine judgment. there, less than one icu admission would be prevented but there would be just over one serious blood clot per 100,000 immunised. if we look at a period of high virus transmission, such as january, there, among the over 60s, 127 icu admissions would be prevented and nearly seven in the over 20s. neela stills began suffering headaches and nausea a week after having the astrazeneca vaccine. he died of a blood clot on the brain on easter sunday. his sister, a pharmacist, says he was extraordinarily unlucky. despite what has happened to neil and the impact on ourfamily, i still strongly believe that people should be going ahead and having the vaccine. if you have had one dose, go ahead and have your second. if you haven't had a dose yet, make sure you do. overall, we will save more lives by

for nearly all age groups, the benefits of the oxford—astrazeneca vaccine far outweigh any potentiall of virus circulation, for every 100,000 vaccinated, ia icu admissions would be prevented. at the same time, there would be a 0.2 or one in 500,000 risk of a rare serious plot. 500,000 risk of a rare serious clot. for people in their 20s, it's a finerjudgment. there, less than one icu admission would be prevented, but there would be just over one serious blood clot per 100,000 immunised. but if we look at a period of high virus transmission, such as january, there, among the over 60s, 127 icu admissions would be prevented and nearly seven in the over 20s. neil began suffering headaches and nausea a week after having the astrazeneca vaccine. he died of a blood clot on the brain on easter sunday. his sister, a pharmacist, says he was extraordinarily unlucky. despite what has happened to neil and the impact on ourfamily, i still strongly believe that people should be going ahead and having the vaccine. if you have had one dose, go ahead and have your second. if you haven't had a dose yet

vaccine _ by providing the oxford—astrazeneca vaccine at _ by providing the oxford—astrazeneca vaccine on what we can provide and the material goods— what we can provide and the material goods we _ what we can provide and the material goods we can provide now like ventilators that we thankfully don't need any— ventilators that we thankfully don't need any more here and we are sending — need any more here and we are sending them overand need any more here and we are sending them over and the oxygen production machines which are being sent over— production machines which are being sent over from northern ireland, but also it— sent over from northern ireland, but also it is— sent over from northern ireland, but also it is the — sent over from northern ireland, but also it is the vaccine and the ability. _ also it is the vaccine and the ability, the deal that was done so that india — ability, the deal that was done so that india can produce its own vaccine — that india can produce its own vaccine based on british technology that is— vaccine based on british technology that is the — vaccine

march, more than a dozen countries, including france and germany, suspended their use of the oxford astrazeneca shop over the blood clot issue. but most eu nations restarted its use in mid-march after the ema said the benefits outweigh the risks. u.k. prime minister boris johnson addressed the issue at an astrazeneca manufacturing facility on tuesday. >> the best thing people could do is look at what the advice is to people, to keep going out and getting your jab, your second jab. >> but it is one of many agencies still investigating the blood clot concerns. in the u.s., the fda has not given the green light pending its own study in the world health organization and is investigating thblood clot concerns. if confirmed, the chances appear to be low, with a german study finding 31 cases of blood clots and nine deaths out of two point 7 million people vaccinated. the ema is expected to make an official statement sometime this week. >> that is the latest on the astrazeneca vaccine. let's bring you the latest on covid-19 across france. the figure is up 913, a total of 5626 people in intensive care d

a trial of the oxford—astrazeneca vaccine on children is suspended in the uk, while the country's regulatorof china's parents are limiting themselves to a single child, despite now being allowed to have more. translation: for me, - it's already hard to raise this one.

the uk's medicines watchdog has made a change to its advice on the use of the oxford astrazeneca vaccinee. it stressed that the benefits of the vaccine continue to heavily outweigh any risks for the vast majority of people. but because some rare blood clots have been found in extremely small numbers of people who have received the astrazeneca jab, those under the age of 30 will be offered an alternative vaccine instead where possible. earlier, the chief executive of the and hr eight, june rein, gave more details about those who had been affected. 0ur who had been affected. our review is that the risk of this side effect remains extremely small. by side effect remains extremely small. by the 31st of march, over 20 million doses having been given, we have had 79 case reports up to and including that date, the 31st of march. all 79 cases occurred after the first dose. of these 79 cases, 19 people have sadly died. these cases occurred in 51 women and 28 men aged 18 to 79 years. from these reports, the risk of this type of rare blood clot is about 4 million —— about four people in a million w

medicines regulators have concluded there is a possible link between the oxford astrazeneca vaccine and where blood clots. they insist the risk of the coronavirus is greater than the risk of death from clotting. the number of virus deaths in brazil has dipped slightly from a record high of 4200 announced on tuesday. another 3800 deaths were reported on wednesday with 92,000 new infections. as he has throughout the pandemic, president bolsonaro continues to play down covid-19. an expert and a the use of force has testified at the trial of the police officer accused of killing george floyd. she said derek chauvin used inappropriate deadly force. >> do you have an opinion to a degree of reasonable uncertainty for how much force was reasonable to use on mr. floyd was handcuffed and not resisting echo >> yes. >> what is that opinion? >> my opinion is no force should have been used once he was in that position. >> the u.s. has agreed to withdraw all the remaining combat forces deployed to fight against isil. talks with the iraqi government did not settle on a timeline. some soldiers and coali

thats because evidence is emerging of a link between the ox serve astrazeneca -- the oxford astrazenecand very rare blood clots. the u.k. regulator set up until the end of march, there had been 79 cases of rare clots with low platelets following a first dose of the astrazeneca vaccine. 19 people have died. that is out of 20 million who received the jab. that is one where clot -- one rare clot in every 250,000 vaccinations. >> these systems are detecting a possible side effect of the covid-19 vaccine, astrazeneca. in an extremely small number of people. the evidence is firming up. the balance of benefits and known risks of the vaccine is still very favorable for the vast majority of people. reporter: very few adults under 30 have died from covid, so that changes the risk-benefit balance from getting a vaccine. it's thought younger adults are at higher risk from clots after the astrazeneca jab. about one in every 100,000 doses. so they will be offered a different vaccine when there time c --ir times comes. are you worried this might damage vaccine confidence, especially in the young? >> t

toll passes 200,000 — but the real number is almost certainly much higher. 0ne dose of the oxford/astrazenecapfizer vaccine halves the likelihood of a person who gets coronavirus passing it on. the bafta tv nominations have been announced. sir steve mcqueen's bbc drama small axe leads the way — with 15 nominations. and coming up — how self—driving vehicles could be allowed on uk roads by the end of this year. good afternoon and welcome to bbc news. a formal investigation has been launched into the funding of borisjohnson's downing street flat refurbishments by the electoral commission. the watchdog announced it was �*satisfied that there are reasonable grounds to suspect that an offence or offences may have occurred'. mrjohnson came under sustained pressure from the labour leader during prime ministers questions about whether he'd initially borrowed the money. the prime minister said again he had covered costs but has asked the new advisor on ministers interests to advise on whether any further statements are needed. 0ur political correspondent iain watson reports. dominic cummings lit the po

. >>> health authorities in the united kingdom are urging the public not to avoid the oxford/astrazenecaaccine. they say all three of britain's approved vaccines are safe. that's after british officials confirmed the potential but rare link to blood clots. salma abdelaziz explains. >> reporter: british health officials are now rushing to reassure the public after it was confirmed that there is a potential link between very rare cases of blood clotting and the oxford university and astrazeneca vaccine. the uk health secretary saying this shows that the regulatory bodies, the checks and balances behind the vaccine, are working because they were able to detect very rare incidences, four out of a million. that is the likelihood of these very rare cases of blood clots occurring. however, it is of course causing confusion, concern and global repercussions with several countries taking steps to limit the use of this vaccine in certain age groups. australia say they are now going to have to recalibrate their vaccine rollout to give this vaccine to only those over 50 years old. italy as well now

will there be new advice regarding the oxford—astrazeneca vaccine?s medicines regulator and the european medicines agency are currently investigating a possible link with rare blood clots in younger adults. they are due to updated advice later today or on thursday. in the uk, trial of the vaccine on children in the uk has temporarily been halted. the university of oxford has told the bbc that there are no safety concerns with the trial itself. 0ur medical editor, fergus walsh, reports. nearly 300 children, aged 6—17 are taking part in the astrazeneca vaccine trial in england which began in february. 0xford england which began in february. oxford university said there had been no blood clots and volunteers but out of an abundance of caution it had stopped vaccinations pending the outcome of the safety review in adults. more than 18 million people in the uk have received the astrazeneca vaccine. the mhra said last week the happy 30 rare cases of blood clots including seven deaths. —— there had been 30 rare cases. the prime minister, visiting an astraze

. >>> the oxford/astrazeneca vaccine is facing yet another setback.he university is pausing its pediatric trial in the uk as regulators review a possible, i say possible link to blood clots in adults who have been inoculated. a spokesperson says no safety concerns have been raised regarding the children's trial. european regulators are once again reviewing the vaccine and are expected to release their findings sometime this week. for more on all the latest developments melissa bell is standing by for us in paris. first we go to salma abdelaziz in london. a lot on the line for astrazeneca but also for the uk and other european countries. this is their best shot to try to get over this pandemic. what's at stake here as we wait for more information on astrazeneca? >> reporter: paula, i'm going to expand that a little bit. it's not just about the uk and the eu, there is a lot of excitement around the oxford university and astrazeneca vaccine when it first came out because it only costs about $4, it is cheaper than your cup of coffee and it doesn't need to

remember we have now got three vaccines, oxford astrazeneca, pfizer. vaccines, oxford astrazeneca, pfizerore transmission in the community, and of course with these new variant strange such as the south african strains, we don't want that to become prevalent in this country because the vaccines don't work quite as well. so i think he is trying to be cautious for everybody. we all want to get our lives back and enjoy ourselves again, but we must be cautious and do this slowly, otherwise we will go back to square one. 50 otherwise we will go back to square one. , .,, ., . otherwise we will go back to square one. , ., . ., otherwise we will go back to square one. ., . ., ., ., one. so people who want to go to the ub, sit one. so people who want to go to the pub. sit outside _ one. so people who want to go to the pub, sit outside a _ one. so people who want to go to the pub, sit outside a cafe, _ one. so people who want to go to the pub, sit outside a cafe, go _ one. so people who want to go to the pub, sit outside a cafe, go for- one. so people who want to go to the pub, sit outside a cafe,

the uk's medicines regulator, says the oxford—astrazeneca vaccine is safe but under—305 will now be offeredalternative covid jab, because of more evidence linking the jab to rare blood clots. the european medicines agency has said any blood clots should be listed as a very rare side effect. myanmar�*s ambassador to the uk says his embassy in london has been taken over by the burmese military and he's been locked out. kyaw zwar minn, who opposed february's military takeover in myanmar, says he's been the victim of a kind of coup in the middle of london. indirect talks between washington and tehran have continued in vienna. the us state department has said america is prepared to remove sanctions on iran, in order to resume compliance with the 2015 iran nuclear deal. president trump pulled the us out of the agreement in 2018. now on bbc news, it's hardtalk with stephen sackur. welcome to hardtalk. i'm stephen sackur. if afghanistan is to find a way out of seemingly never—ending war, the next few weeks will be critically important. the biden administration is pressing the afghan government and

the uk's medicines regulator, says the oxford astrazeneca vaccine is �*safe�*. under—305 will be offered an alternative covid jab — due to further evidence linking the jab to rare blood clots. the european medicines agency says blood clots should be listed as a very rare side effect. the british government says it will provide targeted help to the hundreds of thousands of hong kong citizens expected to move to the uk using a special visa. the chinese government has introduced a security law there which restricts longstanding democratic freedoms. at the murder trial of the former police officer, derek chauvin — the prosecution has reversed part of its evidence over the words uttered by george floyd. after initially accepting mr floyd had said "i ate too many drugs" — they now believe he actually said "i ain't done no drugs. now on bbc news, it's hardtalk with stephen sackur. welcome to hardtalk. i'm stephen sackur. if afghanistan is to find a way out of seemingly never—ending war, the next few weeks will be critically important. the biden administration is pressi

prime minister's former senior aide, a new malaria vaccine developed by the team behind the oxford—astrazenecar's former senior aide,

a trial of the oxford—astrazeneca covid vaccine on children has stopped giving outjabs while the uk'sor investigates a possible link with rare blood clots in adults. the university of oxford has told the bbc that there are no safety concerns with the trial itself, but its scientists were waiting for further information. 0ur medical editor, fergus walsh, says the decision has been taken out of an abundance of caution. there are no safety concerns in the volunteers, they simply thought it would be sensible to stop vaccinating while this adult review was going on. now, no medicine, whether it's paracetamol or vaccines, is risk—free, but unpicking whether there is a link between the astrazeneca jab and these incredibly rare blood clots is frankly difficult. and the incidents in the uk is thought to be one case in every 600,000 vaccinations, in germany, it's higher, nearly all there involving younger women. and each case has to be investigated. did those involved have underlying conditions, did they have covid, which increases your risk of clots, and is there a connection between them? we

a trial of the oxford—astrazeneca vaccine on children has been partly suspended while scientists investigatesible link with rare blood clots in adults. the university of oxford has told the bbc that there are no safety concerns with the trial itself but that scientists were waiting for further information. the medicines regulator, the mhra, is reviewing rare cases of thrombosis that have been reported in adults who've been vaccinated. parents and children are being told to continue to attend all scheduled visits and the prime minister borisjohnson has urged people to get their vaccination, when invited, to reduce the risk of a third wave of infections, as our medical editor fergus walsh reports. nearly 300 children aged 6—17 are taking part in the astrazeneca vaccine trial in england which began in february. oxford university said there had been no blood clots in the volunteers but out of an abundance of caution it had stopped vaccinations, pending the outcome of the safety review in adults. more than 18 million people in the uk have received the astrazeneca vaccine. the mhra said last week

boris johnson's call to keep taking the oxford astrazeneca jab makes the front of the guardian, as ukestigate rare reports of blood clots. they have part of states to limit —— parsed a trial for teenagers and children. but a government adviser suggested to the telegraph that until regulators have made their conclusions, the vaccine roll—out should be paused for younger people. meanwhile the i says contracting covid is linked to mental health problems, including anxiety disorders so let's begin... good to have you both back again. kicking off at the metro come halls to cost the packet. a good headline but this has come from the boss of easyjet. but this has come from the boss of eas “et. , ., , ,., , but this has come from the boss of eas 'et. , ., , , ., but this has come from the boss of eas 'et. , , w easy jet. yes, absolutely, a chief early may — easy jet. yes, absolutely, a chief early may chief — easy jet. yes, absolutely, a chief early may chief executive - easy jet. yes, absolutely, a chief early may chief executive of - easy jet. yes, absolutely, a chief early may chief execut

the uk's medicines regulator, says the oxford—astrazeneca vaccine is safe, but under—305 will now beered an alternative covid jab, because of more evidence linking the jab to rare blood clots. the european medicines agency has said any blood clots should myanmar�*s ambassador to the uk says his embassy in london has been taken over by the burmese military and he's been locked kyaw zwar minn, who opposed february's military takeover in myanmar, says he's been the victim of a kind of coup in the middle of london. indirect talks between washington and tehran have continued in vienna. the us state department has said america is prepared to remove sanctions on iran, in order to resume compliance with the 2015 iran nuclear deal. president trump pulled the us out of the agreement in 2018. now on bbc news — click. this week — need a new career? this is where the jobs are. the new smart city in the desert. and the robots that can build more robots. what could possibly go wrong? welcome to click. it was exactly one year ago that i stood on this beach, looked into that camera and said some pret