and that it belonged to a larger family of protein folding disorders which were pioneered by stand passner. he described jack object cry field disease as a difees-- we now realize that in addition to that, alzheimer disease that you and i talked about, front to temp oral dementia in addition to parkinson's disease, and huntington's disease are pro phone folding disorders. what does that mean. that means prot teen can exist in two confirmations. one is the normal confirmation in which it does its normal physiological function but it flips into the abnormallal confirmation t forms aggregates and these bundles of proteins are toxic. they kill cells. more over, they also release by the cells, taking up by other cells and in turn these aggregates kill the cells that take them up. so this is a way of propagating the disease, extending it throughout different parts of the nervous system. that is a profound insight, which allows us to think that there may be a unifying theme connecting these disorders. and perhaps allowing us to get a completely new therapeutic approach to this. so we are going to