interventions and recently nci supported researchers developing two new interventions against pediatric leukemia and lymphoma and this was initially developed in the academic sector and has been picked up by venture capital and is vapdly going forward for clinical trials. and we also have interacting with the pharmaceutical industry to try to identify new and important uses for drugs that are off the shelf, either because they have been approved for one intervention but not for another, for example, braf inhibitors in melanoma, trying them in other diseases. this is a potentially very important innovation because we recognize that a percentage of patients who have different kinds of cancers may actually have the same molecular abnormalities and therefore may benefit from targeted treatments initially developed in other areas. i could go on, but i think that given the time -- >> yeah. can you just tell me why immunotherapy is effective in some patients but not in others who have the same cancer? >> yes. i think that this is a critically important issue and i think that what we are doing to suppor