. >> reporter: a raw, personal look at the drug epidemic, from perri peltz, and hbo's documentary, "warningilies. different stories. different parts of the country. what they all have in common is that each of these families, each of these stories, began with a prescription, from a doctor. a real legitimate prescription for pain. >> reporter: like stephanie, who took painkillers after getting kidney stones as a teenager. and then, started sharing them with her sister, ashley. >> we didn't know what could happen. you know? we just thought, well, our tr started giving us these painkillers. so, can't be that bad. >> reporter: the sisters got hooked. ashley overdosed and died. as did winn doyle, a mother of three. and brendan cole, a promising young athlete. >> for the longest time, i couldn't come in this room. it's like the day he died. it took me a year to come in and throw his garbage out. >> reporter: just a few of the tens of thousands of deaths a year from overdoses. now, a number greater than from car crashes. what do you see is the biggest obstacle in this country to grappling with thi