well i think what he everyone has been talking up to now is the idea this is in the brain and for phrenologythe question is where in the brain, and real estate counts, you have to actually know which part of the brain does what. it isn't a big bowl of soup, add serotonin and stir which was really the concept that moving from psycho therapy to pharmacology embraced, moving into the brain was the first step, but the issue is, how to dissect the symptoms, the syndromes into the component parts because while it is an involvement of many parts of the brain, its, it is involvement of specific parts of the brain, and the way we approached that was we couldn't do it as we usually did in neurology by dissecting the brain after someone died like you would after they had a stroke and say they couldn't move their arm or they had a language disturbance. there weren't large lesions in the brain with people with depression so we had to take advantage of functional imaging methods i know you have talk about on other episodes. >> rose: right. >> could actually literally say when you are depressed what areas