r. winston touched on it very nicely when she indicated that the patho physiology of a child's train is substantially altered with an injury, and differs substantially from adults. one of the areas that we have to really investigate has to do with the onset of lifelong disease processes that arise from the changes in the brain metabolically and neuro physiologically. once altered, it's difficult to know if these changes actually revert to normal or not. there's great suspicion, for example, in pediatric injury, that neuro enthrow crin abnormalities relate to further mature appropriately. as a consequence, we have to call into question the role of even a cult brain injury, much less more obvious brain injury and conditions that might lead to dyslexia, agraph i can't, confidentiali confidentiality difficulties with reading, writing, math and so on. that we have bundled under learning disabilities as an example. further, as we see the difference in medication differences, fa pharmacologic interventions that are not effective with children or put children at risk that can be used in adults.