it is based on rebecca skoot's best selling nonfiction book. >> oprah winfrey plays lacks' daughter." star portrays henrietta lacks. >> my brother is all upset because everybody come around and make mama off of mama's cells. i don't care about. that i want to know about my sister and my mother. you got to promise me no matter what, you ain't going to lie and you ain't going to keep nothing from me. >> i promise. >> you better get yourself idea what you're getting yourself into. [ laughter >> no idea what you're getting yourself into. say that again. >> you have no idea. do you have any idea. >> literally. >> we're pleased to welcome oprah winfrey along with rose byrne, and renee. this is the thing, oprah. even i who know you so well, i lost all the oprahness when i was watching. i didn't think that was possible. >> oh, that's good. >> everybody who has seen that is saying that. not just me. interesting to hear you say you were intimidated. i remember when you took the role i remember you said i don't want to embarrass myself. >> i surrendered my hands to george wolf and being able to