ten years ago you could have bought regenron, speculation, five bucks. what would happen with that $500? how about this? a gain of roughly 9,900%. not a double, not a triple. not a quadruple. regenron is a ten-bagger but you couldn't have gotten in on that gain if you hadn't taken a risk in 2005 and bought a company with no profits and only the promises of a ceo that things would work out. regenron worked out in a major way but many small cap biotechs have done long and lost you money over a short period of time. you won't always identify who the winners in this space but that's okay as long as you cast a wide net and speculate, taking small positions in ten of these speculative bio techs, nine of them are going to zero. as long as the tenth was one regenron, you still would have made a monster gain. there should only be one small part of your diversified "mad money" portfolio but it belong there because the risk reward of trying to find speculative winners makes sense when you're young. for older investors, though, speculation is much more risky and i r