robert pigott, bbc news. i'm adnan nawaz.ma has given his farewell address to the nation. in a farewell speech to supporters in chicago, mr obama listed achievements including economic growth, the nuclear deal with iran and legalising same—sex marriage. but he also warned of continuing threats to us democracy, including inequality and racism. mr obama praised the armed forces for, in his words, taking out tens of thousands of terrorists, including osama bin laden. donald trump has complained of a political witch hunt against him after unconfirmed reports emerged in the us media that russian intelligence had gathered compromising information about him. the claims are unsubstantiated. ajury in the united states has sentenced to death a white supremacist who killed nine black worshippers in a south carolina church. dylann roof was convicted last month of more than thirty charges us president barack obama has given his farewell speech in chicago, where he reflected on his time in office. he said, "by almost every measure, america

here's our health correspondent robert pigott.at five feet ten inches and weighing a little over 18 stone, gordon wainwright of malvern in worcestershire can no longer expect swift access to the second hip replacement he needs. the pain from his osteoarthritis wakes him up at night and his mobility is badly compromised. but new restrictions on surgery mean he would have to lose 10% of his weight before he could qualify for surgery. it's a very sharp pain, very sharp pain. it's not an ache. it's very, very sharp. i turn over in bed, and it's like... i haven't really been fully fit in terms of being able to walk properly, or gojust for a walk, pre—2013. it would dramatically change my life. the first total hip replacement was carried out

here's more from our health correspondent robert pigott. five feet ten inches and weighing a little over 18 stone, gordon wainwright of malvern in worcestershire can no longer expect swift access to the second hip replacement he needs. the pain from his osteoarthritis wakes him up at night and his mobility is badly compromised.

robert pigott, bbc news, brighton.he finishing touches to their work, on big chunks of ice dragged out of the nearby river. the sculptures range from animals and cartoon characters to replicas of famous world monuments and landscapes. the contest has attracted over thirty teams from countries around the world. ice, snow, iwonder ice, snow, i wonder if some of that might apply nearer home. let‘s cross over and get the latest on the weather from matt taylor. over and get the latest on the weatherfrom matt taylor. good evening. good evening. we could see some of that faith snow later in the week. at the moment, a great, dull day. a murky and misty night. there could be some fog around, particularly on the higher rates. it‘s going to be a damp night with patchy rain and drizzle. clearer skies at times. east england at least in scotland particular. in eastern scotland, temperatures may drop low enough for a touch of frost, but most time i‘ll start a sunday. i today, a dull as dismal one. misty this around, patchy rain just

robert pigott, bbc news, brighton.rom mars which is some 127 million miles away. the image was taken from nasa's most powerful telescope orbiting the red planet. the reddish feature near the middle of the face of earth is australia. a young fan of the coldstream guards now has a memento from his birthday visit to windsor castle. marshall scott was celebrating his fourth birthday at the castle, dressed as a miniature guardsman, when one of the guards surprised him by posing for a photo alongside the youngster. the video was shared online by charanpreet singh, one of the guards involved. time for a look at the weather. it is gloomy. not very inspiring. a lot of cloud. but some sunshine for a few of us, particularly the tops of the hills. that is the exception. for most of us it is dull. some persistent fog patches around to add to the misery. for most of us, not too rosy. some dampness in the south—west but persistent rain is easing away. tonight, the fog will become more thick in some spots, so become more thick in some

robert pigott, bbc news.se to its highest in 18 months. the rac says both fuels went up by three pence a litre during the festive month alone. our business correspondent theo leggett is at a petrol station in west london. anybody who's been to a petrol station like this one recently will probably have noticed that prices have been going up, but they went up particularly sharply in december. 3p a litre for both petrol and diesel. the reason for that is pretty clear. at the beginning of december, there was news from 0pec, the oil producers' cartel, that oil producers' cartel, that oil producers were going to reduce their output. petrol and diesel, producers were going to reduce their output. petroland diesel, made producers were going to reduce their output. petrol and diesel, made from crude oil, that pushes the price up. we have further falls in the value of the pound during the december and that doesn't help because crude oil is priced in dollars. that was december alone. if you look at the year as a whole,

our health correspondent, robert pigott, reports.nter crisis like none before. unprecedented pressure in the new year led almost half to declare a major alert, with doctors warning that patient safety was being compromised. today, the government said gp surgeries were partly at fault, failing to provide the access that patients need, forcing them into accident and emergency departments instead. the government wants surgeries to open from 8am in the morning to late in the evening and open seven days a week, unless they can prove there is no demand. they say they will withhold extra funding unless gps comply. i have worked as a nurse for many years in the nhs and i know that every winter is difficult in the nhs. but this winter in particular has seen the highest number of people ever attending a&e. and so we have to make best use of oui’ resources. and funding is tight and if gps are not going to be open when the public need them to be open, then that funding can be directed to other places in the nhs, such as a&e. but gps say they're

robert pigott, bbc news, brighton.s seen from mars, which is some 127 million miles away. the image was taken from nasa's most powerful telescope orbiting the red planet. the reddish feature near the middle of the face of earth is australia. a young fan of the coldstream guards now has a memento from his birthday visit to windsor castle. marshall scott was celebrating his fourth birthday at the castle — dressed as a miniature guardsman — when one of the guards surprised him by posing for a photo alongside the youngster. the video was shared online by charanpreet singh, one of the guards involved. cute. let's look at the weather forecast now with john. bearskins are all the rage it appears. they come in handing later on in the week, when it turns a lot colder. it's not too cold at the moment. it's relatively mild. but awfully gloomy. some of the hill tops here in derbyshire. if you see much in the way of blue sky today you will be doing well. you can see the cloud cover. that cloud has been producing some rain. noticeab

robert pigott, bbc news, brighton.rding to councils in england and wales who say the government should pay for the repairs from fuel duty. the government says it's already putting £250 million into fixing the problem, but the local government association says that's not enough, as duncan kennedy reports. councils fix two million potholes every year. we have all been overcome around and through portals. —— potholes. councils fix two million potholes every year. that is about 12,000 for every local authority in england and wales. now, the councils claim the repair bill could soon reach £14 billion. hard—pressed councils, who are mending, you know, a pothole every five seconds in this country, just cannot get to the core of the problem, which is actually many of our roads arejust being patched now. they need to be fully repaired. the councils say the government must do more to help and suggest increasing fuel duty by a couple of pence a litre, a figure they say the public would support. the government says it has already

as our health correspondent robert pigott reports, it's challenged the nation to rethink its approach some of the most popular foods in the awarding includes some of the most popularfoods in the british awarding includes some of the most popular foods in the british diets such as crisps, chips, cakes and biscuits. the longer they are cooked above 120 celsius the more acrylamide they contain. those foods go for eight browning process which many of us like in terms of flavour and taste at it also produces this acrylamide. the sugars in starchy foods such as your breakfast toast combined with the molecules that make up protein to produce acrylamide that can damage the dna in cells. we know that in animal studies is can create cancer and so we are concerned if there is the same mechanism in people that high exposure could increase people's risk. the fsa says people should go for gold aiming for gold and yellow in baking, roasting, frying or toasting rather than something darker. it says eating a balanced diet rich in vegetables will guard against cancer. cancer research uk says acrylamide

robert pigott, bbc news, brighton.e made? well, there's a cafe in portsmouth that can satisfy both your curiosity and your tastebuds. dougal shaw reports. meet tea entrepreneur andrew gadsden, standing to attention outside his teashop in portsmouth. a decade ago, he left the navy to set sail on a new career. he decided to follow his twin passions, tea drinking and surfing the internet. back on dry land, he bought himself a tea bag making machine... ..and ran an online shop from his flat. as his business grew, he had to move his operation to a warehouse. people started peering through the window and wanted to come in and asked us if they could have some tea and it was getting very awkward having to say no all the time. they would say, "well, what do you do?" we would say, "well, we sell tea." "well, can we have some?" "no." but eventually he bowed to customer pressure and built a tea room inside the factory. entirely by accident, we were running a little cafe. i don't know if you can hear it right now but we've usually

robert pigott, bbc news, brighton.or castle. marshall scott was celebrating his fourth birthday at the castle — dressed as a miniature guardsman — when one of the guards surprised him by posing for a photo alongside the youngster. the video was shared online by charanpreet singh, one of the guards involved. wait for it. due notice that lance corporate rat paul eden didn't smile for the camera. let's look at the weather forecast now. how's it looking? quite right, standards. i will smile for you, because i'll try and cheer you up from the gloomy weather which we've had today. for most of us it's been distinctly drab and some of that fog has been lingering all day long. for a few of us, it's been beautifully sunny. that's the exception to the rule. the satellite picture says it all. you can see the cloud, the murk across the uk and nothing's going to shift it now really. any breaks in the cloud won't amount to much. temperatures into double figures in most spots. that mild theme continues into the night. that fog could l

robert pigott, bbc news.d said that he has done a good job but he chose to leave early because of the timing of brexit conversations. huge pressure over brexit with theresa may and her team. lots of questions asked about what her objectives are, whether her tea m what her objectives are, whether her team is ready whether whitehall generally has the expertise to conduct these negotiations. there has been criticism this week from somebody on the inside, the former ambassador, what downing street has tried to do is seize back the initiative, get on the front foot with this swift appointment of sir tim barrow, and that has been well received, many people praising him, praising him for his expertise, for his enthusiasm. downing street will certainly be hoping that the relationship with him will be smoother than with his predecessor. he isa smoother than with his predecessor. he is a very experienced and seasoned diplomat, very tough, he was the ambassador in moscow for many years. he has worked in the eu before, s

robert pigott, bbc news, brighton.pers. the writer paul vallely is here to tell us what's caught his eye. good morning to you, thanks for coming in, we have been talking about this hacking, the alleged hacking, claims of hacking in america, that is the first story you have spotted. the first thing was that cartoon, the genius cartoonist from the times as a small pea in the brain of donald trump, and it is understandable why when you read the story. it tells you that the evidence that the various us intelligence agencies have given to trump is very direct, it says that putin himself ordered this campaign of hacking, not just putin himself ordered this campaign of hacking, notjust something that has been done by freelance agents off their own bat. and the reason the pea brain struck me as being so apt is that he is consistently in denial at the facts of the story, co nsta ntly denial at the facts of the story, constantly trying to divert them in different directions. basically, he is fed up of the idea that people will t

robert pigott, bbc news. disarray" according to the british medical association. the comment follows a report by the national audit office which urges ministers to reconsider plans to increase weekend and evening access to family doctors in england. it says many gps are already struggling to provide existing services. the department of health says it's promised additional funding and 5,000 extra doctors. a white supremacist, dylann roof, has been sentenced to death for the racist killing of nine black men and women at a church in south carolina in 2015. the 22—year—old opened fire during a bible studies class. he rejected a final chance to plead for his life, telling the jury he felt he "had to carry it out". a pedestrian has died in brighton after being knocked down by a car being chased by police. it happened last night when police say a vauxhall astra failed to stop and was pursued by officers. the car hit a person on st james's street — the force is still trying to trace the driver. a 29—year old british

robert pigott, bbc news.d has died, aged 51. she had suffered from a stroke. two people have been killed and more than five injured following a car bomb next to a courthouse in the turkish city of izmir. youngsters are frequently giving personal information away on the internet, according to the children's commissioner for england. i'm vishala sri—pathma, in the business news. sports direct chairman keith hellawell has been re—elected to his position on the board. but he lost the support of independent shareholders. his re—election was carried by founder mike ashley, who maintains a controlling stake in the company. the company has been dogged by criticism over its treatment of staff and corporate governance. younger generations will inherit much more money than their parents and grandparents, but the amounts they get will be very unequal. research by the institute for fiscal studies says the wealth of the older generation has grown by 45% over just ten years. the uk service sector grew at its fastest pace fo

our health correspondent robert pigott reports.the nation's diet. food scientists say best selling products such as risks, ca kes, selling products such as risks, cakes, crisps and biscuits contain a compound that can damage the dna in cells. it is created when the molecules that make up protein reacted high temperatures. toast roast and fried can create it. we know in animal studies it can create cancer and so we know in animal studies it can create cancer and so we are know in animal studies it can create cancer and so we are concerned, if there is the same mechanism in people, that higher exposures could increase people's rests. the official advice is to make fry and grill to a lighter colour, following instructions on packaging carefully, not storing potatoes in the fridge and eating a balanced diet to minimise the risk of cancer. even our daily toast is under scrutiny. the food standards agency says we should go for gold rather than brown or, still less, black. with toast on the menu at this glasgow cafe, the advice got a mixe

robert pigott, bbc news.ia webcam from toronto. how confident are you in these findings, they are startling. we looked at two other conditions, parkinson's disease and multiple sclerosis and we found no association between those illnesses and ultimately to traffic, so the finding is relatively specific to dementia, which adds to credibility. we heard in that report that there could be other factors, we heard in that report that there could be otherfactors, associated with living close to big roads, that might contribute to dementia, disturbed sleep, for instance, stress and so on, do you think that is right, or do you think this is all about is right, or do you think this is allaboutair is right, or do you think this is all about air quality? our study can only look at how close people live to major roads, and you are quite right, there is a number of factors that change as one moves closer to a roadway. noise and levels of traffic related air pollutants, and this study is not able to discern between those tw

our health correspondent robert pigott reports.of the most popular foods in the british diet, such as crisps, chips, cakes and biscuits. the longer they're cooked above 120 celsius, the more acrylamide they contain. those foods go through a browning process, which many of us like in terms of flavour and taste, but it also produces this acrylamide. the sugars in starchy foods such as your breakfast toast combine with the molecules that make up protein to produce acrylamide that can damage the dna in cells. we know that in animal studies it can create cancer and so we are concerned if there is the same mechanism in people that high exposure could increase people's risk. the fsa says people should go for gold, aiming for gold and yellow in baking, roasting, frying or toasting rather than something darker. it says eating a balanced diet rich in vegetables will guard against cancer. cancer research uk says acrylamide might be harmful to people but insists there are other far bigger proven dangers — being obese, drinking too much and esp

here's our health correspondent robert pigott.r 18 stone, gordon can no longer expects twixt access to the second slip hip replacement he needs. the pain from his osteoarthritis wakes him at night and his mind mobility is badly compromised. but new restrictions on surgery mean he would have to lose 10% of his weight before he would qualify for surgery. it isa before he would qualify for surgery. it is a very sharp pain in my hip. it's not an acre, it is very sharp. i haven't really had... been fully fit in terms of being able to go for a walk since before 2013. it would dramatically change my life. the first total hip replacement was carried out in an english hospital in1962, carried out in an english hospital in 1962, more than 50 years on this revolutionary procedure is being widely rationed. the clinical commissioning groups will exclude from the hip and knee replacements patients who rank as morbidly obese oi’ patients who rank as morbidly obese or those whose pain is not sufficiently severe to interfere with their daily life.

here is our health correspondent robert pigott.sion at the age of ten to have his stunted right leg amputated, his dream of a future in sport seemed remote. would you like to put it on for me, and show me what you can do with it? three years on, he is one of the first children to receive a running blade on the nhs. as if he were changing shoes, he can swap his false leg for the blade, and feel a new freedom and energy. this spring of it is the bit that makes me go faster. i used to not be able to, like, be able to run as fast, or able to kick a ball as well. but now i've got a good amount of power in my leg, and i've got the right size. so i can do loads of skills, and hit a ball really well. the blade and the treatment cost around £1000. but clarejohnson, a health service expert in prosthetic limbs, says the nhs will more than recoup the cost by keeping children active. we hope that will give them a level playing field, so that he can compete with his peers, and be able to participate in a lot more sports. it does help in the wide

our health correspondent robert pigott reports.tals have faced a winter crisis like none before. unprecedented pressure in the new year led almost half to declare a major alert with doctors warning that patient safety was being compromised. today, the government said that gp surgeries we re government said that gp surgeries were partly twofold —— at fault to provide access for patients in need forcing them into emergency departments. the government wants gp surgeries open from eight a.m. until eight p.m. surgeries open from eight a.m. until eight p. m. seven surgeries open from eight a.m. until eight p.m. seven days a week unless they can prove there is no demand. they say they will withhold extra funding unless its compliance.” have worked for many years in the nhs and every winter is difficult. this winter in particular has seen the highest number of people ever attending a and e. we need to use oui’ attending a and e. we need to use our resources to the best they can. funding is tight and if gps will not be open when the public

our health correspondent robert pigott reports.ylamide that can damage the dna in cells. it‘s created when the sugars in these starchy foods react with the molecules that make up protein at temperatures above 120 degrees celsius. starchy foods, when you cook them at high temperatures, toast, roast, fry, they can create acrylamide. the longer and the hotter, the more acrylamide there will be. we know in animal studies it can create cancer. so we are concerned if there is the same mechanism in people, the official advice is to bake, fry and grill food to a lighter colour, follow instruction on packaging carefully, avoid storing potatoes in the fridge, where the cold produces more sugar, and eat a balanced diet to minimise the risk of cancer. even our daily toast is under scrutiny. the food standards agency says we should go for gold, rather than brown, or still less black. with toast on the menu at this glasgow cafe, the advice got a mixed reception. i would think twice, yes. think twice about it. because i eat quite a lot of burnt t

our health correspondent robert pigott reports.ish diet, such as crisps, chips, cakes and biscuits. the longer they're cooked above 120 celsius, the more acrylamide they contain. those foods go through a browning process, which many of us like in terms of flavour and taste, but it also produces this acrylamide. the sugars in starchy foods such as your breakfast toast combine with the molecules that make up protein to produce acrylamide that can damage the dna in cells. we know that in animal studies it can create cancer and so we are concerned if there is the same mechanism in people that high exposure could increase people's risk. the fsa says people should go for gold, aiming for gold and yellow in baking, roasting, frying or toasting rather than something darker. it says eating a balanced diet rich in vegetables will guard against cancer. cancer research uk says acrylamide might be harmful to people but insists there are other far bigger proven dangers — being obese, drinking too much and especially smoking. let's see what the w

here's more from our health correspondent robert pigott. second hip replacement he needs. the pain from his osteoarthritis wakes him up at night and his mobility is badly compromised. but new restrictions on surgery mean he would have to lose 10% of his weight before he could qualify for surgery. it's a very sharp pain, very sharp pain. it's not an ache. it's very, very sharp. i turn over in bed, abd it's like... i haven't really been fully fit in terms of being able to walk properly, or go just for a walk, pre—2013. it would dramatically change my life. the first total hip replacement was carried out in an english hospital in 1962. more than 50 years on, this revolutionary procedure is being widely rationed. the clinical commissioning groups in wyre forest, redditch, bromsgrove and south worcestershire will exclude from hip and knee replacement patients who rank as morbidly obese or those whose pain is not sufficiently severe to interfere with their daily life. the royal college of surgeons says the restrictions are not clinically justifie

leaders accuse the government of failing to address an nhs funding crisis. 0ur health correspondent robert pigottented pressure in the new year, led almost half to declare a major alert doctors warning patient safety was being compromised. today the government said gp surgeries were partly at fault, failing to provide the access patients need, forcing them into accident & departments instead. the government wants surgeries to open from 8am until 8pm and open seven days a week unless they can prove there is no demand. they said they will withhold extra funding unless gps comply. they said they will withhold extra funding unless gps complylj they said they will withhold extra funding unless gps comply. i have worked as a nurse for many years in the nhs and i know every winter is difficult, but this winter in particular, i have seen the highest number ever attending a&e so we have to make best use of resources. funding is tight and if gps will not be open when the public need them to be open when the public need them to be open, the funding can be directed to other places in the nhs such as a&e. but

with me is our health correspondent robert pigott. nhs and how to struggling, here is another one. the first week of this new year and we hear about all of these major alerts. these figures do distil some of the other stories that we're been hearing about. i think the thing to ta ke hearing about. i think the thing to take home from mrs that these major alerts are quite serious. eight of the mother most serious level, which is partly defined as something where patient safety and care can be compromised. this is serious stuff. routine operations have been cancelled an extra staff being called in. we have the human side we re called in. we have the human side were people of the waiting ambulances and inside hospitalfor treatment. it is worth bearing in mind that this 46% of hospitals which issued these alerts, one third of hospitals in england were still on the celeb status for the rest of that week. and this is treble the number before christmas. it into your real peak here. it is normal winter demand but it does speak to an early ches

here's our health correspondent robert pigott. how have you been doing since you had your leg?t leg amputated, his dream of a future in sport seemed remote. would you like to put it on for me? three years on, he is one of the first children to receive a running blade on the nhs. as if he were changing issue, he can swa p as if he were changing issue, he can swap his false leg for the blade and feel a new freedom and energy. this spring is the bit that makes me go faster. i used to not be able to, like, be able to run as fast or able to kick a ball as well. but now i have a good amount of power in my leg and i have got the right size. soi leg and i have got the right size. so i can do loads of skills and hit a ball really well. the blade in the treatment cost around £1000. but clarejohnson, the treatment cost around £1000. but clare johnson, the expert treatment cost around £1000. but clarejohnson, the expert in prosthetic limbs says the nhs will more than recoup the cost by keeping children active. we hope that will give them a level playing field so that he can compete with hi

here's our health correspondent, robert pigott.an no longer expects swift access to the second hip replacement he needs. the pain from his osteoarthritis wakes him at night and his mind mobility is badly compromised. but new restrictions on surgery mean he would have to lose 10% of his weight before he would qualify for surgery. it is a very sharp pain in my hip. it's not an ache, it is very sharp. i haven't really had... been fully fit in terms of being able to go for a walk since before 2013. it would dramatically change my life. the first total hip replacement was carried out in an english hospital in 1962, more than 50 years on this revolutionary procedure is being widely rationed. the clinical commissioning groups will exclude from the hip and knee replacements patients who rank as morbidly obese or those whose pain is not sufficiently severe to interfere with their daily life. the royal college of surgeons says the restrictions are not clinically justified and will often be a false economy. if a patient continues to be in pai

our health correspondent robert pigott reports., cakes and biscuits contain a molecule called acrylamide that can damage the dna in cells. it‘s created when the sugars in these starchy foods react with the molecules that make up protein at temperatures above 120 degrees celsius. starchy foods, when you cook them at high temperatures, toast, roast, fry, they can create acrylamide. the longer and the hotter, the more acrylamide there will be. we know in animal studies that it can create cancer. so we are concerned if there is the same mechanism in people, the higher exposure could increase people‘s risk. the official advice is to bake, fry and grill food to a lighter colour, follow instruction on packaging carefully, avoid storing potatoes in the fridge, where the cold produces more sugar, and eat a balanced diet to minimise the risk of cancer. even our daily toast is under scrutiny. the food standards agency says we should go for gold, rather than brown, or still less black. with toast on the menu at this glasgow cafe, the advice go

here's our health correspondent robert pigott. said ambulances queuing outside hospitals were visual testament to the crisis in the nhs. the royal college, which represents 33,000 specialist hospital doctors, said patients faced lengthening waits on lists, on trolleys, in accident and emergency departments and at home. it blamed a shortage of qualified staff, stretched too thinly to meet the increasing demands. our members fear that people's lives are at risk because they can't get round to see the patients that aren't yet in the emergency department or indeed are waiting for results to come back. members and fellows have been writing in and our council members specifically have said to me this is the worst they have ever seen. most urgent, said the doctors, is investment in social care to prevent medically fit patients being trapped in hospitals. in their own letter to the prime minister, 75 charities and individuals working in health and social care said there must be a long—term cross—party solution to what they called the cris

robert pigott reports.des some of the most popular foods in the british diet, such as crisps, chips, cakes and biscuits. the longer they're cooked above 120 celsius, the more acrylamide they contain. those foods go through a browning process, which many of us like in terms of flavour and taste, but it also produces this acrylamide. the sugars in starchy foods such as your breakfast toast, combine with the molecules that make up protein, to produce acrylamide that can damage the dna in cells. we know that in animal studies it can create cancer, and so we are concerned if there is the same mechanism in people that high exposure could increase people's risk. the fsa says people should go for gold, aiming for gold and yellow in baking, roasting, frying or toasting rather than something darker. it says eating a balanced diet rich in vegetables will guard against cancer. cancer research uk says acrylamide might be harmful to people, but insists there are other far bigger proven dangers — being obese, drinking too

here‘s our health correspondent robert pigott.bulances queuing outside hospitals were visual testament to the crisis in the nhs. the royal college, which represents 33,000 specialist hospital doctors, said patients faced lengthening waits on lists, on trolleys, in accident and emergency departments and at home. it blamed a shortage of qualified staff, stretched too thin lead to meet the increasing demands. our members fear that people‘s lives are at risk because they can‘t get round to see the patients that aren‘t yet in the emergency department or indeed are waiting for results to come back. members and fellows have been writing in and our council members specifically have said to me this is the worst they have ever seen. most urgent, said the doctors, is investment in social care to prevent medically fit patients being trapped in hospitals. in their own letter to the prime minister, 75 charities and individuals working in health and social care said there must be a long—term cross—party solution to what they called the crisis in