professor robin shattock,, thanks for being with us this sunday afternoon.d this decision to extend the time between the first and second dose. what are the first and second dose. what are the risks and potential advantages of doing that? well, the potential advantage of having a wider gap is you can get more people to receive their first dose and that may well prevent them from ending up in hospital in the short term. and certainly, there is evidence there to support that for the astrazeneca oxford vaccine. the evidence for the pfizer vaccine is less robust. it is only for three weeks, we don't know what level of protection a single dose might give over a period of up to 12 weeks. the potential risk is if it is a suboptimal immune response, although it may reduce hospital admissions it may give the virus a window to evolve mutations that may render the vaccine less efficacious in the future, so it is really a judgment call. there is no obvious right decision and people are trying to make the right balance over presenting the hospitals continue to have high