the bbc�*s sean farrington spoke to the company's boss and started by asking him how much of an impactve on the world. obesity is known, and has been shown in surgical intervention studies, but also in lifestyle intervention, when you can mitigate obesity in adulthood, you can mitigate downstream disease at some scale. there are estimates that 40% of healthca re costs, and maybe a little more that of chronic disease for adults is connected directly to overweight and obesity. of course, cardiovascular disease and diabetes are the largest categories of those things, but there are many, many other untoward conditions that can be impacted by obesity. we know that if people can lose weight by diet and exercise, which is the first line of care, and we have long—term studies on surgical intervention, and now short—term interventions like medicines that lilly makes, we can impact the diseases that are downstream of overweight and obesity. if these medicines work like diet and exercise, or medical interventions, we have an chance to address 40% of adult disease, which is pretty significant impa