seroquel xr is one option proven effective to treat bipolar depression.y, it's one pill, once a day here is some important safety information... you should be aware of. call your doctor if you have unusual changes in mood... ...behavior or thoughts of suicide. antidepressants can increase these... ...in children, teens and young adults. elderly dementia patients taking seroquel xr... ...have an increased risk of death. call your doctor if you have fever... ...stiff muscles, and confusion as these may be signs of a life-threatening reaction... ...or if you have uncontrollable muscle movements... ...as these could become permanent. high blood sugar has been reported with seroquel xr and medicines like it... ...and in extreme cases can lead to coma or death. your doctor should check for cataracts. other risks include decreases in white blood cells, which can be fatal, seizures... ...increased cholesterol... ...weight gain, dizziness on standing, drowsiness,... ...impaired judgment, and trouble swallowing. use caution before driving or operating machinery. le