we begin tonight with siddhartha mukherjee and a remarkable new book called "the emperor of all maladies: a biography of cancer." >> cancer is like a car. when the car works, the cancer cell is like a car. when the car works properly, it's accelerator and brakes are very much a fundamental part of the car. you can't imagine the car without acceleration or brakes. yet if you jam the accelerator inappropriately or if you snap the brakes inappropriately, then this car-- which is adapted to accelerate and stop-- begins to become unable to accelerate and stop. >> rose: it has a life of its own. >> exactly. and you've got to admire the extraordinary mechanism that's inside every one of our cells that allows this automatic process or acceleration and braking to happen normally. the fact that we grow up as these incredible multicellular organisms, sometimes i say to myself, it's extraordinary that we're not exploding with cancer. >> rose: we continue with a new movie called "love and other drugs" with the actors anne hathaway, jake gyllenhaal and the director ed zwick. >> one of the things that