we've seen shire make two big acquisitions, $5 billion acquisition in 2015 of course, last year, takedaought ariad for $5 billion. people wonder if the tax overhaul has had time to be digested by the big companies in order to pull the trigger next week on a big deal we'll be watching that company also do a lot of guidance and early reporting of q4 results, there we'll be watching celgreen, always the first company to kick off this conference, of course, they had a really tough fourth quarter. that's going to be a huge one to watch. regeneron, vertex, acorda. last year, it was that week that president trump -- president-elect at the time, made those comments. listen to this >> our drug industry has been di disastrous, they're leaving left and right. day supply our drugs but don't make them here they're getting away with murder pharma, pharma has a lot of lobbies. a lot of lobbyists a lot of power and there's very little bidding on drugs we're the largest buyer of drugs in the world, and yet we don't bid properly we're going to start bidding and we're going to save billions of dollars ove