tpa is a proven agent for the treatment of ischemic stroke. it is a clot buster. it reopens clots that are blocking blood vessels and restores blood flow to threatened regions before irreversible injury has occurred. one of the main surgeons felt it was very important that i see her right before they started the procedure, and so they took me in, and they were just very quickly preparing her. at that point, she wasn't... she couldn't speak, she couldn't say anything. we didn't have more than a minute, and karen doesn't remember anything. i just went in and tried to pretend that it was no big deal, and it was like holding back tears and stuff. time was critical in the use of the clot buster, tpa, to counter the effects of karen's stroke. when blood flow is blocked to the brain, a number of processes leading to cell injury begin to occur immediately, and unless the blood flow is restored within a few hours, then the brain that's at risk is irretrievably lost. so unfortunately, we have learned that the time window for intervention in acute stroke is very brief, on th

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