symptoms, multiple areas of the brain that weren't functioning normally, some were over active, some underactive different combinations in different patients but there started to be a pattern and there started to be the nodes in what would become a pulteive network that was involved in major depression, what are the big areas? the ringleader as the data has evolved overtime, is this area 25, the sub -- it is an area deep in the frontal lobe, and it seems to always show itself whenever there is an intense negative experience .. area 25 is the negative mood regulator, but it is also associated with areas like the mend la, the prime .. hub for mediating all stress responses. >> emotional responses. >> emotional responses, actually anything novel gets processed originally through the amen does la. >> they have an .. intimate relationship with one another, other area that are important regulate drive, like the hypothalamus, this is the core, many nuclei are involved in sweet, appetite, libido, a direct ling between area 20 give and the hypothalamus and that and the mendula, and memory context is ther