about 25 percent of people with uni polar depression also suffer from bipolar depression. fortunately, we have been able to get .. various treatments of them. one of the most remarkable treatments came from larry burn this ime and i should introduce this as we saw in schizophrenia where a number of the drugs were introduced by accident designed for other purposes in drug that person i'm i'm, bernhime was initially used for tuberculosis, but this was, he was an ordinary, she was an extraordinary farm colonel gist, and she, pharmacologist, she .. discovered this enzyme, this inhibitor of the enzyme and moved to duke and became the main stay of the pharmacology department at duke university and had an extraordinary career. this drug was later picked up, a particular strairnt of this, and used for tuberculosis, which was thought to be its target, and astute clinicians actually here in new york noticed that patients on tuberculosis were jump jumping around, most of the others were fatigued? what depressed, these people were happy and comfortable, and somebody got the idea let's

uni polar depression is, as you indicated was appreciated as early as hypocrites i the fifth century bce thought all diseases of the body were due to imbalance between the four humors, they didn't think of diseases as being organ specific but -- >> blood, phlegm, yellow bile and black bile and depression was an excess of black bile, in deprpr a very famous 17th century psycho analyst by the name ofillm shakespeare. your friend. he had hamlet say, hour wary, stale, flat and unprofitable seems to me all the uses of the world. and as you pointed out the character features depression which we are going to hear about as a sense of hopelessness, helplessness, low self-esteem, an unending poor mood, a sadness, relentless day in and day out, associated with deep psychic pain. this is very common disorders worldwid about five percent of the population suffer from deprotection at one time or another and the united states it is the major disability in people between 15 and 45 years of age. and it is also associated with sort of a loss of interest of what is going on in the world, it is a very d