we're talking about unmetered customers. it is customers that have stormwater runoff but they don't pay a bill because they don't have a water meter. so we don't have a way to apply to them. the point of this agenda item is to develop rules to apply the sewer rate to customers that are unmetered. it's not a new rate. it's a methodology change. we're also gearing up for bigger and longer term changes. one of the goals is to incentivize property owners to have it on their properties. it does help our system. we would like to be able toll reward customers for having it. we would of -- we would like to institute a credit program. we are also having a grant program. $8 billion budgeted in the next two years. we'll use a lot of outreach to provide benefits for the services to customers. so turning now to the rules in front of you today and come up with a methodology. we sent out a letter in february with a proposal that was going to be a flat monthly charge for all parcels within the city. and we got great feedback from customers

but four percent he said that yesterday in a meeting with unmet need a secretary jenin jens stoltenberg and he again tweeted that this morning why this is so focused on who for its nato has been. genuine new fields and i think it's safe to say that that most european allies and especially germany in this place have been free riding on nato have been neglecting their military and even the german minister of defense has said recently that the bundesrat the german military the german army is in bad shape and something needs to be done and the german chancellor hinted at that as well saying yes we know we need to do more and it seems like trump is someone who hits home a message here and i'm not no psychologist but yet so my message here everybody says yes you're right more or less we're going to do more but he just keeps on getting that message although he's already accomplished what he wants to do what he wants to accomplish and nevertheless that's the message the main message coming out of the summit first of all the alliance is still together and second of all everybody agrees that the

. >> depression is a leading cause of suicide and one of the leading areas of unmet medical need andeading cause of workplace morbidity. our current therapeutic options have been in place almost two decades and a positive innovation and real reluctance to think differently how we might treat these patients more urgently and more effectively. >> when i did get to interview you, postpartum depression, i was shocked to know, there's really nothing you've got something that could be very close. >> we're really excited about this this is in intravenus treatment. you're talking 400,000 plus women in the u.s. alone who get this diagnosis, one of the leading causes of maternal death after childbirth no leading help. we have a 70% remission rate after 2 1/2 days of treatment. >> that's staggering what would it be if people had nothing? what do they tell people, take aspirin? what do they have. >> they have re-up take inhibitors and you get on that drug 6-8 weeks and maybe on it chronically. in the u.s. alone, 25 million people are chronically on antidepressant therapy alone the idea to get a

and vicky who volunteered for random act just couldn't let that need go unmet and offered up her garage and her expertise to continue making beautiful arrangements for people experiencing some difficult times. >> we really want to make a statement for them because you never know. it may be the last flower they ever receive. >> reporter: vicky started her non-profit, flowers of comfort, with just three other volunteers. but once she posted to her next door social network about a need for vases. >> and i got not only vases but i got volunteers. so making new friends. >> reporter: there are close to 20 other women working with vicky, and on this day they a w and flower whole salers into almost taking some to her mother and others at a senior care facility in coopertino. >> there's so much joy in their eyes. >> reporter: vicky says she knew it would be a lot of work, it has been, but the results are something to behold. >> i think it's turned out nice. >> some flowers come from stores where they can't sell them any longer, but they still have another week of life or so from whole salers or

this has to do with the unmet medical needs that exist in china.atientse world cancer reside in china. history oflong provisional therapies that are not global therapies for these patients. china, if they get cancer, they think he must there be is the answer, whereas the rest of the world has moved on to immunotherapy and targeted therapy. china has this enormous unmet medical need, with global standards and policy technology. biotech companies are moving rapidly to fill that gap. matt: has the investment community gotten too excited? when this happens, people overpriced shares. christian: the last couple of years, china med, we have been operating for 18 years. we have been grinding away for that time. candidates in over 30 political studies around the world. -- medical studies around the world. others in china have done that over a very long time. over the last couple of years, we have blossomed. several companies have been listed on nasdaq. we have all done very well. what that led to is a huge influx of financial investments into the industry.

, but the need still is, and vicki, who volunteered for random acts, just couldn't let the need go unmet. >> that's a hospice one. >> and offered up her garage and expertise to continue making beautiful arrangements for people experiencing some difficult times. >> we really want to make a statement for them, because you never know. maybe the last flowers they ever receive. >> vicki started her nonprofit, flowers of comfort, with just three other volunteers, but once she posted to her next door social network about a need for vases -- >> i got not only vases, but i got volunteers. making new friends. >> there are close to 20 other women working with vicki, and on this day, they turn donations from a wedding and flower wholesaler into almost 100 arrangements. she'll be taking some to her mother and others at a senior care facility in cupertino. >> so much joy in their eyes, yo forowrd for every monday. >> vicki said she had to think long and hard about stepping up and on work. it has been. but the results are something to behold. >> i think it's turned out nice. >> the flowers vicki gets a

we know there is a lot of unmet need. lot of people who die before meeting their full life expensive c-suite -- expectancy. we need a sustainable environment for innovation and access. guy: coming talk about a bit about your perspective? how much money do you want for and what is the value do you expect to get for it? do have a clear idea in your mind? announcement the to spin out, to our shareholders, we are quite excited. con as a $20oal billion market that continues to grow. it is the market leader both in the device segment and vision care segment. it is really being spun into its own company from a position of strength. i think you heard from us the billion dollars-$30 billion we have already put out in the public domain. that is going to depend on the market at that point in time. i think the key thing is when you look longer-term at this business. this is a strong business, a market leader with a strong innovation portfolio that can grow well into the future. to when it has its freedom increase its capital as it se

costs is because it's taking longer to for competitive to emerge where specialty drugs are targeting unmet medical needs. i want to share a snapshot of what we found. we plan to publish the full results really soon. for non-orphan drugs, 41% of the first in class drugs approved between the years of 1991 and 2000 had at least one competitor in the same class within five years. this rate dropped sharply over the next decade. for the same kind of drugs approved between 2001 and 2010 only 18% had a within class competitor after five years. another way of interpreting the data is to describe the lag in competiti competition. for the drugs approved in 1991 to 2000 nearly a quarter had a competitor within two years. for the cohort of drugs where the first in class medicine was approved between 2001 and 2010 it took an additional five years for there to be nearly as much competition. by year seven competition still lagged with only 22% of the new cohorted drugs having any competitor. we see similar patterns in most rare disease treatments as well. these trends mean that cost clear branded drugs ma

specialty drugs that target unmet medical needs are enjoying monopolies for long period of time. if you believe the competition jaded a data shows competition comes in market prices go down. we now have data to demonstrate this we will be publishing that soon. i think there are things we can do to try to facilitate more efficient root markets for second and class and third in class drugs. at the same time increasing being effective not sacrificing anything. those are the type of development we are focusing on. >> trials for diseases can be difficult to conduct especially if there's a fda approved treatment already in the market. how do you focus your clinical trials on rare diseases? >> one thing in particular is looking at natural history models, model the behavior of the control arm or model simulation. you'll have to enroll placebo trials because if there is already therapy people don't want to use placebos. they want to use an active drug. this is the place we could benefit from more disease models. we should be able to create those. there is a request of the president's budg

he capitulated to russia in syria, the unmet redlines, his betrayal of poland and the czech republic russia's demand to remove the fence systems there. he betrayed the ukraine by refusing them defensive weapons. contrast that disaster, utter appeasement, to what trump has done in the 18 months. he's expanded sanctions on russian companies, he's beefed up nato. he's had a massive increase in u.s. defense spending, no thanks to the liberals, restoring missile defenses to poland and the czech republic. returning heavy armored divisions to germany. repositioning armored brigades in the baltic. ending arms embargoes on the ukraine and georgia that obama imposed on victims of russian aggression. ending the ban of oil exports when it tries to compete with the russians oil. i could go on and on on this, these are notes i have typed out. all of this hysteria, the fact of the matter is trump hasn't done a thing to harm america with respect to russia and obama did nothing to protect america when it came to russia, the same attitude obama had when it came to the chinese in the south china sea. t

and vicky, who volunteered for random act just couldn't let that need go unmet. and offered up her garage and her expertise to continue making beautiful arrangements for people experiencing difficult times. >> we mainly want to make a statement for them because you never know, it may be the last flowers that they ever receive. >> reporter: vicky started her nonprofit flowers of comfort with just three other volunteers. but once she posted to her nextdoor social network about a need for vases -- >> i got not only vases, but i got volunteers. so making new friends. >> reporter: there are close to 20 other women working with vicky and on this day, they turned donations from a wedding and flower wholesalers into almost 100 arrangements. they will be taken to a senior care facility. >> there is so much joy in their eyes, they just look forward for it every monday. >> reporter: vicky says she had to think long and hard about stepping up and taking on this role. she knew it would be a lot f woof wo work. but the results are something to behold. >> i think it turned out

some projects have been energized like the randall museum and unmetered traffic lights and signals. at least for the projects taking place in 2018, as the general manager mentioned, we've identified a path, or a process, on how these projects will be treated in hopes that will prevent further delays. >> can you describe what that path is? >> so we've come to an understanding that pg&e will require electrical equipment that's better to find for us for facilities that are of a 500 kva size. >> what do you mean better defined. >> well, so we have in the wholesale distribution tariff that pg&e has on file at firk, electric electrical configurations. for these projects that are pending and expect to be through the pg&e application process before the end of 2018. >> i know you're going to get to this in your presentation, but any understanding is one of the biggest issues that have caused delays in many city projects is the sort of seemingly arbitrary requirement of whether or not pg&e requires us to have a primary or secondary distribution system. at what point in the project development

yes, our political, economic, social expectations have been long the unmet by our government will stop however, when we look at the country around us, at least we're not that. at least we're not iraq, syria, afghanistan. at least we are not these countries that the united states has directly or indirectly helped destroy political, economic, and social fabric of these countries. they just did a poll, the arab center in washington, d.c., they pulled the broader airport -- the broader arab world about popular and unpopular. guess who was number one unpopular? us. iran was number four. us. oftentimes we say, and the arabian people of them is pro-american people in the middle east. i would say it differently. . would say they were the least you can like the government and still simultaneously not appreciate the united states of america trying to strangle you economically. value your currency and destroyed the fabric, political, economical, and social and side the country. >> so what is the iranian response? if the sanctions go online and august? if the european and other countries pullout?

action with an expert panel to advise ministers to prescribe in exceptional cases where there is an unmetions and in the case of a cannabis prescription the senior doctors will need to lead the application to the expert panel. a lot of you have been getting in touch. maria says, i think cannabis oil should be allowed for medicinal purposes. i suffer with a degenerative disc disorder and most days i am in chronic pain. another says, this is heartbreaking, i cannot fathom why it is bad if it helps children have a better quality of life. a very brave mother, i hope even of life. a very brave mother, i hope eve n gets of life. a very brave mother, i hope even gets the help he deserves soon. an anonymous text saying, when will the government finally wake up to medicinal cannabis? it is nowhere near enough and it is insulting to patients and we are 20 years behind other countries and it is embarrassing. keep your thoughts coming on that story. theresa may will call on the european union to "evolve" its position on brexit when she makes a speech a little later this morning about the irish border

for allies for making that happen, and i also want to call out that more than half of our need was unmet last year. i would challenge you to ensure that we help fully fund the work of trans orgs and help serve one of san francisco's most marginalized and under funded communities. the mayor's office of budget has left cultural districts in an untenable position. thank you. >> supervisor cohen: thank you. next speaker. next speaker. >> dear board of supervisors, i am rishe, and i work with the t.g. justice project. a lot of our trans brothers and sisters face high rates of unemployment, poverty, and homelessness due to discrimination. it is really important that we open doors and have equal access to employment, housing, mental health services, access to name changes and overall full support for our trans communities and continued budget will allow us to do that. i'm asking support for your community and budget justice coalition. >> supervisor cohen: okay. next speaker, please. >> good afternoon. my name is kyle neal, and i'm here on behalf of t.g.i. justice coalition. >> supervisor cohen:

things simultaneously, meaning, yes, our political, economic and social aspirations have been long unmet by our government. however, when we look at all of the countries that surround us, at least we're not that. at least we're not iraq. at least we're not syria. at least we're not afghanistan. at least we are not these countries that the united states has dreirectly or indirectly helped destroy the political, economic and social fabric of these countries. they just did a poll -- who was it, the arab center, washington, d.c. -- just did a poll where they went and polled the broader arab world about unpopular governments. guess who was number one? us. iran was number four. that's not a good place to be, but us, we were number one. lots of times we say, well, the iranian people are the most pro-american country in the united states. i would say they are the least anti-american. you should want your government to fulfill your actions while simultaneously not appreciating the united states of america trying to strangle you economically. so value your currency and destroy the fabric of politi

but it's also maybe even the largest unmet need wells believes in it morgan stanley believes in it.pmorgan said it's good. if this is real, then the stock is going to be much higher than this why do i say if it's real? because, there have been a half dozen drug companies given up trying to find a cure. this would be incredible so those who believe up 40 is not too much. >> you've said you're saying earlier this morning this could be prime for break out the way the chart sort of looks. >> very much. >> all the good had been taken out of it by the 2017 announce want getting this news is rather extraordinary. now w we want to be sure everyone understands this is the holy grail if you can reverse plaque millions of people suffer from it it hasn't been able to be anywhere near successful for so many big drug companies. this is a big one. >> all right the opening bell minutes away. "squawk on the street" will be right back ♪ the kenya tea development agency is an organization that is owned by tea farmers. every week we sell this tea, we get paid in multiple accounts. we were looking for a

the backlog is an unmet need for tribal justice facilities has grown significantly since fiscal year 2014 when the department of justice unilaterally stopped new and replacement construction of travel justice buildings. all the while, the bureau of indian affairs has kept condemning these types of buildings. thisny neglect, lack of federal coordination between agencies has resulted in communities being forced to go without essential infrastructure. tribal justice officials dictate that risk -- that the risk of their lives to provide basic law and order in native american communities. however, the former -- as a former police officer i can tell you, no justice system can function without a safe and secure facility to house these officers. the san carlos apache tribe's justice system is a devastating example of the back willing for justice facilities in indian country. the b. biai condemned the building known as building 86 in 2009. the tribal police officers and courts worked for six additional years in a condemned building in the the bureau of indian affairs provide them with tempora

according to the international finance corporation, micro, small and medium-sized enterprises have an unmet financing need of over $5 trillion every year. in emerging markets. depriving them of the capital that they need to grow. foreign investment is critical to empowering entrepreneurs, critical to creating jobs, to reducing poverty. our country has an undeniable interest in supporting the development of vibrant and stable economies around the world. healthy -- a health fromy private sector promotes good -- a healthy private sector promotes good economy, it helps reduce civil strife, and the resulting stability is good for our national security and also benefits u.s. exports and jobs. increasingly other countries are working to advance their economic and political interests by shaping overseas markets. china's build one road initiative is estimated at $1 trillion. this dwarfs the size of the marshall plan that rebuilt war-torn europe in the 1940's and 1950's. across africa and asia and beyond, beijing is making massive investments in new construction and infrastructure projects from the h

. >> over 500 requests for sheltering assistance for domestic violence victims go unmet. victims of cry for help. is claire mccaskill listening? even after her husband was accused of abusing his then them, another for slap in the face for victims. mccaskill's campaign had several responses. they released a brief statement from the ex-wife blasting the attacks, saying i support claire and hope she is reelected. the attack is terribly unfair in the worst kind of disgusting, dirty politics. claire will not be discussing her husband divorce which occurred more than 20 years ago. missourians deserve so much better. quotes one campaign spokeswoman saying he doesn't like personal attacks. that is some of the information coming out with the 90 odd something days until the november elections. again, that is part of the positioning that brings the president into this as of yesterday, talking about this idea of a shutdown. int before those elections, order to achieve efforts on border security. if you agree with this idea of a 748-8000. 202- 748-8001.sagree, 202-7 caller: last night

virgin islands addressing unmet housing business and infrastructure needs in the impacted areas. in addition, a substantial amount of these recovery dollars will be invested in making disaster-prone areas stronger, making it possible for them to weather future disasters. taxpayers support hud's mission, and they expect us to use their moneys wisely. maximizing the impact of every dollar and minimizing waste. since becoming secretary, i've been intensely mindful of our responsibility to fulfill our mission as responsible stewards of their hard-earned dollars. in march, i took a number of important steps to strengthen the financial integrity of the agency and correct lax internal processes and controls. central to this effort is hud's chief financial officer irvin dennis who joined the department in january after a distinguished career in the private sector. i have directed irv to design a plan and lead an internal task force to combat waste, fraud and abuse. we simply need to do better, and we will. in conclusion, mr. chairman, hud is committed to safe, fair and affordable housing

that are in demand and necessary and i can tell you, in every hospital system i represent, there's an unmet demand, thousands and thousands of individuals are needed. might i have an additional 45 seconds? mr. takano: i yield an additional 45 seconds. the speaker pro tempore: without objection, the gentlelady is recognized. ms. kaptur: importantly, prehealth students in the pilot will gain a deeper understanding of veterans' specific health needs which is critical for health professionals who treat veterans, many of whom have complex conditions, as the chair and ranking member know. one of our to top responsibilities as a -- our top responsibilities as a congress is to make sure that our veterans, those who sacrificed so much for our country and for liberty's cause, receive high-quality health care from highly trained health professionals and this bill furthers that effort and i'm pleased it will get a vote this evening and i would like to thank my colleagues, mr. takano, for his diligent work on this bill, and ranking member walz and chairman roe, for bringing this bill to the floor so exp

the house bill expands that pathway to any difficult to develop animal drugs that could address an unmet need and doesn't even define what qualifies as difficult. i have been very concerned that the undefined scope of this pathway sets a terrible precedent, and more importantly doesn't uphold the gold standard of f.d.a. approval that our public relies on. however, today dr. gottlieb has made public assurances to both me and our chairman that he intends to implement this provision with additional caution and restrictions according to congressional intent. f.d.a. has committed to promulgating regulations to define what it means for a study to be, quote, difficult. and importantly, f.d.a. has publicly agreed that conditional approval is not an appropriate pathway for any human medical products or antibiotics. antibiotics resistance is a large and growing global public health problem and the rampant overuse of antibiotics in our food supply compounds that problem. i'm very pleased this bill requires f.d.a. to report on its work to bring all medically important antibiotics under veterinary su