vincent millet ezra , pound, anne sexton, percy shelley, it goes on and on, moliÈre, dylan thomas, joseph conrad, herman hesse, herman melville, virginia woolf, the stuff moeller, tchaikovsky, it goes on and on. cole porter jackson , georgia o'keeffe -- it goes on and on. and vincent van gogh, as i mentioned in the introduction. help me understand the link between bipolar and creativity. dr. jamison: it is complicated. some of those people probably had just depression alone. charlie: not bipolar, just depression alone. dr. jamison: one of the ongoing controversies was about the relationship a very recurrent depression to bipolar. it turns out they are pretty closely tied. one is temperament. there is a certain boldness, a certain high-energy capacity for some people with bipolar. if you look at the studies, what is striking is the rapidity of thought. when people begin to get manic, they are thinking speeds up. they have more and more associations and more unusual associations. if you speed somebody up that is not already creative, you are just speeding them up. but if you have somebody creative and give them this high-energy state, they are very determined to do something. going after the highest goals and aspi