we consider ourselves much more than a bookstore but community space that wellcome's communication, author talks and glasses. thank you for coming. meryl comer an award winning 30 year veteran reporter and producer and a talk show host among the first tv newswomen to specialize in business news as a release to public policy with a nationallyííy> syndicated debae show its your business broke shako anchoredéí[j nation's business today. she is now president of the jeffrey been foundation and alzheimer's initiative that she is probably providing 100 percent of the net profits of that in, dedicated to the foundation along with the work of cancer and wounded four years and protection of women and children she has provided testimony before congress served on the 2008 study group and two times on the alzheimer's association and a founding member of u.s. against alzheimer's and the co-founder of women against alzheimer's is at work. alzheimer's affects 36 million people worldwide. her husband was the chief of hematology and oncology at the nih when he was diagnosed with early onset of alzheimer's

wellcome to all of you for, and thank you for being with me. >> thank you, carol. >> and perhaps generaley can answer the ultimate question today. when do we know that we have defeated isis? democratic senator joe manchin is not buying any of it. he told cnn that he is not going to vote to arm those syrian rebels. listen. >> to go in now thinking that we are going to pick when we know that there are hundreds and hundreds of different sector thes and segments of violence over there and terrorists, and we are going to pick and try to segregate 3,000 or 5,000 thinking they are going to make a difference? well, we just armed an army in baghdad and they turned and ran and left the weapons. now with we have pictures of the arsenal, if you will, the humvees and the mraps and everything else that they confiscated from mosul and why would we repeat this? i will vote no, and stand tall in front of west virginia to say why i voted no to arm and train and spend millions on syrian rebels who i don't know who they are and if they are ever going to be loyal to america. >> okay. general marks, is senato