and the people that discovered antibiotics at whoa womack womack these things could stop working because of evolution because these bacteria are evolving fast and you could end up with bacteria that are resistant. unfortunately nothing really happened. there was no big resistance stopping crusade back then and now finally we are coming to terms with board and more resistance and it's a real struggle because we don't have a lot of new drugs in the pipeline we are starting to n get, we are starting to see over the horizon a situation where you have a -- that everything we have got so if you get infected with the end you figure out the strain that combined all these resistance genes there's nothing people can do for you and already it's been estimated maybe 700,000 people the world die of antibiotic arrested and bacterial infections and that could go up unless we do stuff. i don't mean to be the dark cloud in your day. it's the same thing as smallpox. we can do something about this. if people are smart we can solve this problem. we solve smallpox and that was a problem and this is a problem