mr. wyrick: yeah. we know that a central nervous system depressant works throughout the central nervous system. so this is affecting the receptors that are located in the spinal court and in the brain. his point was, perhaps that the receptors may be fully saturated at the spinal cord level. and the brain level. and in his words we paralyzing the brain that the extent that the person is unconscious and unaware of the pain? and he thought that the evidence sufficient to conclude that there was. justice kagan: i think if we go back and read it, that it will show that what he was saying is that we just do not have to worry about the ceiling effect. because the brain level, the ceiling effect has no relevance. let me ask you another question. maybe this is one that we will agree on. maybe not. i am not sure. do you think that if we conclude that there is just a lot of uncertainty about this drug -- in other words, you may be right or miss konrad may be right this. is just impossible to tell. given no studi