the genes that made us, our genes that have survived through countless generations. we look back on your ancestors and every single one of your ancestors, not a single one of your ancestors died before achieving at least one heterosexual compilation. [laughter] obvious, but it is very significant because very, very many of their contemporaries died without for died young were done without having and reproducing. so we contain the genes that helped our ancestors to survive in the past. i've got a phrase which appeared in the book and several other. the genetic book of the dead. the genetic book of the dead is the genes in a modern animal which any fence describe the past. the genes in an animal can be thought of as a kind of digital description of the world in which the ancestors of the past survived. not the present and not the future. and as maryellen has just pointed out, emergent properties. it means that the future is going to be different and in the case of human emergent properties, very very different. because we are changing environment and at breakneck pace.

but that does conserved genes that have persisted through the eons are very likely to be genes that are the most hearty and most adaptable to future scenarios. so it's very important actually to conserve especially species that have the ancient lineages because the conserved genes are perhaps more important than recent genes. >> that is interesting, i did not know that. it is interesting. it is fascinating how some animals, to have conserved things, a very very long time. it is an enormous variance in the shared age of genes. yes. >> to go back to your own words, because it really is more important to stay in your world. although i think they over intersect quite much. right in the introduction you have a sentence that says it is not an unreasonable speculation that consciousness mirrors several progression over time -- to connect that with another essay they have somewhat later. which is a fascinating essay about the internet. in which, you wonder if here is a sentence from it. the check is called net game. talk about how the internet may be changing the way we think. this year sentenc

senator gene mccarthy. if i have to run for president to do it, i'm going to. senator eugene mccarthy august 17th, 1967. [applause] this question is about gene mccarthy and his counterpart you pointed out. i was one of those people who went door to door for gene mccarthy. like young people today who gone door-to-door for bernie sanders keys also opened up the protest and possibility for the future that for young people we see what happens in virginia as a result of the women's march and would bernie did. so in the same way that you have so much accolade for gene mccarthy, my question is why does msnbc and other mainstream news covered the alternative to the establishment point of view and virginia took everybody by surprise. these were all first-time candidates that were inspired by this new wave. that's what i hope for when i listen to the news and we love your show that i would lik but o hear the other voice coming in. it's the other voice berney? >> by would like to hear about the county elections. the p

the brca gene genie is newsworthy and noteworthy because it is unusual. —— the brca gene is newsworthyverall population have a brca gene. it's also known as the angelina jolie brcagene. if you have the brca gene, you jolie brcagene. if you have the brca gene, you are likely to be younger. it is because you have this genetic predisposition that you are likely to get cancer earlier. 0ne predisposition that you are likely to get cancer earlier. one of the key things is the age of the patient as well as whether they've got mothers or sisters directly affected. it's the old story, isn't it? you need to think about these things, you need to get clear advice and agreement from your oncologist 01’ and agreement from your oncologist or whoever is in charge of your case? that is right. the good news is the cure that is right. the good news is the cu re rates that is right. the good news is the cure rates for breast cancer are going up all the time. we are understanding more and more about it. the treatments are getting more and more individualised and there are good outcomes. the majority of wom

one in a50 women carry faulty brca genes.chance of getting breast cancer, and many women with a strong family history of breast cancer opt for preventative double mastectomies, which almost eliminates the risk. like angelina jolie, the actress and campaigner who revealed she had preventative surgery, it led to greatly—raised awareness of brca gene mutations. this study looked only at young women, like laura. 95% of breast cancers are in the over 40s. laura says if she had her time again, she might have delayed having a double mastectomy, but she has no regrets. fergus walsh, bbc news. it's the queen as you've never seen or heard her before. to mark the 65th anniversary of her coronation in 1953, her majesty has been giving a unique insight into the day and what it meant to her. she's been speaking to the royal commentator alastair bruce for a bbc programme. a key piece of advice for any would be monarch — don't look down — as our royal correspondent nicholas witchell reports. she famously doesn't do interviews. this is probab

one in a50 women carry faulty brca genes.nce of getting breast cancer, and many women with a strong family history of breast cancer opt for preventative double mastectomies, which almost eliminate the risk. like angelina jolie, the actress and campaigner who revealed she had preventative surgery, which led to greatly raised awareness of brca gene mutations. this study looked only at young women like laura. 97% of breast cancers are in the over a05. laura say5 of breast cancers are in the over a05. laura says if she had her time again, she might have delayed having again, she might have delayed having a double mastectomy, but she has no regrets. fergus wal5h, bbc news. our top story this evening. donald trump says he won't be coming to london and he's accused of racism over alleged comments about african countries. still to come... music and taking the airwaves by storm — the 21—year—old from norway who's the bbc‘s sound of 2018. coming up on sport5day on bbc news. johanna konta carries british hopes at the first tennis major

gottlieb referred a little while ago to gene therapy. i couldn't help but point out today in the new england journal of medicine, really dramatic advance in hemophilia using gene therapy to develop the gene to the liver of men who are affected. and it's men because it's an x-linked condition. with really remarkable benefit over the course of many weeks. that's just a single example of what is possible in this space. i mentioned earlier my hopes we could cure sickle cell disease by taking out the bone marrow cells, and putting them back. it's a transplant to yourself, a gene editing preach which we also find exciting. recently, this disease called spinal muscular atrophy, in children who are born, seem to be okay, then develop paralysis, and often don't live past their first year. now with a clinical trial, some of these kids are making it to their pre-kindergarten and looking pretty good, again, by a genetic change that's been introduced using either a virus or a gene editing strategy. i think the big barriers right now is just to push t

the gene therapy will also treat a related neurodegenerative disorder. the partnership with sangamo therapeutics deepens pfizer's investment in dna-based treatments. > the food and drug last month approved a treatment for a rare form of blindness marking the first approval of a gene therapy for an inherited disease. the cost of this one-time treatment is $850,000. but along with the high cost comes new potential payment >> reporter: medicin has bee pursuing the promise of gene therapy for decades. the goal, to deliver healthy copies of genes to make up for ones that cause disease. what makes the approach revolutionary is it's aimed to only be administered once to fix the problem. it was only in december that the united states got its first gene therapy approval for a drug from spark therapeutics. it's called luxterna. it treats a rare inherited retinal disease that can lead to blindness, often affecting kids early in their lives. >> let me see that. >> reporter: in clinical trials it helped improve patients' vision in low light. it doesn't necessarily re

in gene therapy that break to spend the development of vehicles that can deliver genes were officially to the target inside the body. these are often referred to as vectors and if they can form of viruses that are specifically engineered for this purpose. in particular the advent of specific kind of largely inert virus was inflection point in this field. i like in the advent of the vectors to the feldman of processes for making antibody drugs and making his medicines nearly identical to fully human cells that they were mimicking. and the fighters represent a promising field breakthrough medicines in the 1990s but for a long time these therapeutic drugs fell short of their promise. that was because these drugs were made with antibodies from mice and antibody drugs as a person rejected by patients in insistence. then came the science dehumanize these antibodies so they would more fully mimic the normal human counterparts. but he soon we saw many breakthrough drugs result. i believe we're at a cemetery point when it comes to gene therapy. over the next over years we'll see this approach b

they are not what we call fate genes. they are risk genes. it is like genes for heart attacks or stroke -- there is no gene that causes a heart attack. jane: finding new treatments has become increasingly urgent. more veterans die from suicide than in combat. but ptsd affects far more civilians. one in four of us will suffer some form of mental disorder in our lifetimes. ken's family could not be spared the tragedy of mental illness, but he hopes others might benefit from paula's death. >> it is a great picture. one of the things we tried to do at her funeral was celebrate her life. one of the things i'm celebrating about her life is she is doing something now for and other people in the future, and i feel and my kids feel very positive about that. jane: jane o'brien, bbc news, maryland. laura: from the science of the brain, we turn to that of the body, and a global team of researchers who have unveiled the world's first bionic hand with the sense of touch. an italian woman has been the first to try it out. medical correspondent fergus walsh

they get tested and find they have the brca gene and do not have breast cancer.ess angelina jolie, decide to have a double mastectomy. this is totally separate from that. that will probably continue. there is one limitation on this study. 0nly will probably continue. there is one limitation on this study. only about 596 limitation on this study. only about 5% of breast cancer cases occur in that very young age group. we do not know about the long—term survival of women with breast cancer who get it ata women with breast cancer who get it at a much older age are more commonly say at the menopause or later. a huge fire engulfed a section of nottingham railway station this morning. around 60 firefighters tackled the blaze, which began at about 6.30am. no—one was injured, but trains are still not stopping at the station and travellers are being warned to avoid the area. phil mackie reports. the severe fire rapidly spread through the recently renovated station at the start of this morning's rush—hour. 60 firefighters were called to deal with the blaze while passengers

one in a50 women carry faulty brca genes.d many women with a strong family history of breast cancer opt for preventative double mastectomies, which almost eliminates the risk. like angelina jolie, the actress and campaigner who revealed she had preventative surgery, it led to greatly—raised awareness of brca gene mutations. this study looked only at young women, like laura. 95% of breast cancers are in the over—40s. laura says if she had her time again, she might have delayed having a double mastectomy, but she has no regrets. fergus walsh, bbc news. it's the queen as you've never seen or heard her before. to mark the 65th anniversary of her coronation in 1953, her majesty has been giving a unique insight into the day and what it meant to her. she's been speaking to the royal commentator alastair bruce for a bbc programme. a key piece of advice for any would—be monarch — don't look down — as our royal correspondent nicholas witchell reports. she famously doesn't do interviews. this is probably as close as she'll get. a conver

one in a50 women carry faulty brca genes. a strong family history of breast cancer opt for preventative double mastectomies,

one in a50 women carry faulty brca genes. chance of getting breast cancer, and many women with a strong family history of breast cancer opt for preventative double mastectomies, which almost eliminates the risk. like angelina jolie, the actress and campaigner who revealed she had preventative surgery, it led to greatly—raised awareness of brca gene mutations. this study looked only at young women, like laura. 95% of breast cancers are in the over 40s. laura says if she had her time again, she might have delayed having a double mastectomy, but she has no regrets. fergus walsh, bbc news. you can keep up—to—date with all our stories including news, business and sport on the website or reaction and analysis from around the world including updated live pages. reports from our correspondence based on 80 international locations and eyewitness accounts. just go to the website. president trump sparks outrage after allegedly making racist comments about african countries. a surgeon who branded his initials on to the livers of two trans

we have fame's gene munster.e has been patiently on that call what stuck out to you, buddy you were on the call for an hour and a half. >> it's been a long call they buried the good stuff in the middle of the call i think cheryl's comment about the monetization actually going up, and i want to translate what she was saying when she said not clearly negative they mentioned they already started to clean up the news feed in the u.s. they gave the numbers. 12% less time spent in the u.s but monetization actually creeped up in the u.s. now they haven't rolled these out over the whole globe that's why she said not clearly negative that is a huge topic in this story. i think she let people rest easy knowing that in fact reducing time can actually be good for monetization what a great combination. >> do you feel, gene, a bigger topic, that facebook has trouble sort of telling people in plain english what it means, not clearly negative zuckerberg has been described as not the best communicator. do you think they are not g

gene ward / (r) hawaii state house:"this is national issue and you're not being reasonable. give me one more question."lawmakers also asked if the military should be responsible for these kinds of alerts...since they're the ones who detect incoming threats...but the governor argues the state should be in control of the alert system. a representative from the federal communications commission said--they are looking into why certain people didn't get some alerts on their smartphones.james wiley / federal communications commission:"by statute, subscribers have a right to opt of receiving notifications that are imminent threats or amber alerts." (jr stone) taking a live look outside....(justine) meteorologist anny hong

gene ward / (r) hawaii state house:"this is national issue and you're not being reasonable. give me one more question."lawmakers also asked if the military should be responsible for these kinds of alerts...since they're the ones who detect incoming threats...but the governor

by gene editing won't get you that. the other complexity here if you take two identical twins, humans, some of you may beware their fingerprints are actually different. even though they have exactly the same genome they've been modified in embryonic development let alone the nurture once they're born. so simply thinking if we can identify the gene, suppliplice put something else in and result in a final human being that will have those traits is far from the reality. nature has levels of complexity. i'm giving you examples that aren't going to let us -- not just one gene, one trait, even when we think that's the case. >> on the other hand there are -- genetics is in some ways revolutionizing pharmaceuticals or certain companies. regeneron has partnered with all sorts of academics that have rare mutations with powerful effect. this company in iceland called decode. because the population is so homogenous they've collected from these individuals and it's easier to spot very powerful mutations associated with different dis

one in a50 women carry faulty brca genes.and many women with a strong family history of breast cancer opt for preventative double mastectomies, which almost eliminates the risk. like angelina jolie, the actress and campaigner who revealed she had preventative surgery, it led to greatly—raised awareness of brca gene mutations. this study looked only at young women, like laura. 95% of breast cancers are in the over 40s. laura says if she had her time again, she might have delayed having a double mastectomy, but she has no regrets. fergus walsh, bbc news. let's return to donald trump because the president visit to britain next month is off. he had been due to attend the official opening of the new us embassy in south london. but he tweeted he was not a "big fan" of the new building. downing street says an invitation for a state visit is still open, although no date has been set. our diplomatic correspondent james landale has more. the new us embassy, on the south bank of the river thames in london. with its very own moat. a monu

so the findings are up12% out who carries this gene.utcome from conventional treatment for those people was no different to those that did not have a brca gene mutation, once you took all the breast cancer characteristics into account. the treatment was appropriate and based on their breast cancer status rather than the brca status. i'm joined now by katharine woods, senior research communications manager at breast cancer now. thank you for coming here to speak to us. let's remind everyone that these brca genes are the ones we all heard about where angelina jolie had the pre—emptive or preventative surgery, double mastectomy, because she was told as a carrier of these genes she had a high risk of developing breast cancer. that's right. the kind of treatment we can give to those women has improved over the years so lots of women who know they carry these genes and have a higher risk of breast and of aiding cancer will have risked reducing surgery would drastically reduces the risk. this is a study of 3000 women that founded double mastec

they are not what we call fate genes, they are risk genes, like genes, they are risk genes, like geneside fan ii'i,, more veterans died from suicide fan in,, but ptsd affects far more civilians. 0ne in,, but ptsd affects far more civilians. one in four of us will suffer some form of mental disorder in our lifetimes. ken's family could not be spared the tragedy of mental illness, but he hopes others might benefit from the death of paul. illness, but he hopes others might benefit from the death of paulm isa benefit from the death of paulm is a great picture. 0ne benefit from the death of paulm is a great picture. one of the things we try to do at her funeral will truly celebrate her life. on some level one of the things i'm salivating about her life is that she is doing something now for science and other people in the future and i feel and science and other people in the future and ifeel and make it feel very, very positive about that. just a few minutes ago, konstantinos in london said as this tweet. he says can you focus on ecological issues, including ways to reduce the use of plasti

now we can map genes and neurons and neurocircuits using a combination of light and a gene that can show you the neurons as being activated and follow the circuit. what you see also here is the ability to do brain machine interface. it's already happening. somebody who has pair plerapleg use the brain to motorize a robot. my colleagues have demonstrated he can actually use brave driving a robot in china to move. this is, in fact, real life, exciting opportunities. of course position medicine. it's not only sequencing genomes, but now you can measure so many things. the power of being able to precisely predict using a combination of data of what to treat and when to treat is amazing. when you think about this, i put down prevention is important. the bat tottom of the slide is neutral genomics. i want to illustrate three diseases where these things are being applied and then get to the whole issue of data and artificial intelligence. so heart disease, cancer and aging. in heart disease, there's a whole slew of new drugs, new imaging and new ways of approaching. importantly, i want to point

without gene here, i wouldn't have been interrupted. wayne, you'll pose as a plumber.ll locate and open the water main, causing a flood in the facility's only restroom. then justin and i will arrive disguised as plumbers. justin will fake a heart attack, and look for darlene's storage unit. meanwhile, beth, posing as a plumber, will cut the power, unlocking all of the units. - shouldn't i be an electrician? - what electrician would cut power, beth? they love power! next time, think! after i have fenton pelt's birth certificate, gene and portia will arrive in the news van disguised as plumbers who took the wrong van. - chuck, you may be over-thinking this. - also, are we going to be reimbursed for the coveralls? - [laughing] if this mission goes right, we'll never have to worry about money again. - how so? - while the guards help gene and portia look for their plumber van, justin and i will make our escape. [chuckles] in and out, boys. [suspenseful spy music] in and out

turns out, each gene codes ultimately for a peptide or a protein, so if you know how many genes you have, you should be able to match those to the number of peptides. turns out, there's several fold multiplication of diversity in the genome, so just be genetics won't get you that. the other complexity here is if you take two identity cal twins, humans, some of you may be aware -- their fingerprints with different. so even though they have the same genome, their phenome is different because of t. is even if we can splice it, it's far from reality. nature has complexity. i'm giving you examples. it's not just one gene, one trait, even if we think that's the case. >> on the other hand, there are some geneticists in some ways revolutionizing pharmaceuticals. regenron has partnered with scientists that are studying populations with a rare defect. also a company in iceland called decode. because the icelandic population is so home okawho h i think one of reasons they bought decode was because they had found in elderly patients a mutation that seemed easier for them to get alzheimer's disease.

records ever since and have finally been able to work out who does and who does not carry the brca geneomen with breast cancer had the brca gene mutation and the outcome from the conventional breast—cancer treatment for those people was no different to those that did not have the brca gene mutation wants you took the breast—cancer characteristics into account. the treatment was based upon their breast—cancer status rather than the brca status. in a moment a summary of the business news this hour but first the headlines on bbc news: donald trump cancels his visit to the uk next month — but downing street insists the "strong and deep" partnership "will endure" dozens of firefighters have been battling a huge blaze at nottingham railway station. the station is shut causing major travel disruption and a breakthrough in talks to form a new government in germany between chancellor angela merkel‘s christian democrats and their former coalition partners, the social democrats. in the business news. bank customers across the uk as of tomorrow will be able to securely share their financial informa

" mutations to the bcra gene.l women over the age of 30. if you carry of the faulty gene, or you've been tested for it, we'd love to hear from you this morning. irrespective of your age. what kind of information did you get from the screening? how has it impacted on your behaviour? what have you done about it? do get in touch on all the stories we're talking about this morning — use the hashtag victoria live and if you text, you will be charged at the standard network rate. our top story today, britain is to increase its contribution towards border controls in france by 44—and—a—half million pounds, and commit to taking more migrants. the money will be spent on fencing, security cameras and body scanners at calais and other channel ports. the deal will be announced at a uk—french summit this afternoon, at which theresa may will conclude a series of agreements with president emmanuel macron. their meeting is being seen as the most important for several years, as our diplomatic correspondent, james robbins, reports.

it's a stunning gene editing technique. that yellow blob is where a gene is getting edited, and the dna is taken out. the next step, replace it with a different gene to fix a bad genetic mutation. >> it's changing biology and the world. >> reporter: in the future it could change disease-causing genes in on embryo. the concern it will also be used to enhance babies, for example making them smarter or stronger. >> that's a world we don't want to live in. >> reporter: this is the executive director for the center of genetics in society at berkeley. she worries parents will be pressured to genetically engineer their offspring. >> so they can get into the right preschool and grade school and college. >> reporter: as for sadie's mom, she prefers mother nature, but can imagine the pressure. >> someone like me decided not to do that, and let mother nature take the lead, will that child billion at a disadvantage -- be at a disadvantage? >> they also caution before the technology is used experts need to ensure we're not increasing so

the goal is to see if gene editing can eradicate inherited disease.tists have shown it is possible to remove a gene in embryos that causes heart disease. it's early days but some believe the technology has the potential to transform medicine. but with ethical and safety concerns others warn that any research needs to advance with caution. in 2017 mysterious mercury was also in scientists‘ sights. it's the smallest planet in our solar system and the closest to the sun, covered in craters, towering cliffs and ageing volcanoes, until now it has been little explored but this year preparations were underway for a major new mission. this is the spacecraft called colombo after a famous italian scientist and the launch will take place in 2018. it is only when you get up close that you get a sense of the size of this huge piece of kit. this is a spacecraft built to withstand extremes, and to get to mercury has to travel towards the sun which means dealing with intense radiation and heat. 0n the surface of mercury temperatures can reach a50 celsius and that is

after i had finished my treatment i had a double mastectomy because i had the brca two gene.alling to hear it might not help me at all. but at the same time, with the information i was given at the time i did everything i could to increase my chances of being around for my children. that is the thing, i guess information is increasing all the time. it‘s difficult isn‘t it for women to make that decision when you are presumably overwhelmed with information and try to come to terms with what you‘re being told. absolutely and that was a good point made about the information at the time. we have new insight all the time. we have new insight all the time from research which helps aid decision—making around treatments and it's not saying that a double mastectomy is not an option and it's also people want to live 20, 30, 40 years. the key thing is in terms of longer term survival they are not saying a double mastectomy is not something people should consider, what it is saying is that people have more time to think about the options and there is more insight and therefore there is m

place that requires hospitals or health care providers to buy expensive therapies upfront gene therapy has made tremendous advancements globally and now the question remains are insurance companies ready to cover a potential six digit medical bill when according to a recent survey most americans can't handle an unexpected five hundred dollar medical bill reporting from washington d.c. david miller r t america. david joins us here on the talk about his report always a pleasure and you said they were the most americans come up for even a five hundred dollar medical bill let alone the price to you talked about in that report. how are they just applying this allows this layer in a tie they just buy it from the c.e.o. standpoint he says this is a science and revolutionary science and they're saying that the breakthrough is and a plain investment so we keep going with this gene therapy you know technology in that therapy so they're saying that you know these breakthroughs lead to investment in the costs of initially would go down eventually would go down now the other interesting play at thi

the technique is called gene editing.r genome — the blueprint for life. a single error in that dna can affect development, trigger disease or cause disorders. now, scientists can scan the genome and use molecular scissors to cut out, replace or repair the gene they want to target. the goal is to see if gene editing can eradicate inherited diseases. already this year scientists have shown it is possible to remove a gene in embryos that causes heart disease. it's early days but some believe the technology has the potential to transform medicine. however, with ethical and safety concerns, others warn that any research needs to advance with caution. in 2017, mysterious mercury was also in scientists' sights. it's the smallest planet in our solar system, and the closest to the sun. covered in craters, towering cliffs and ageing volcanoes, until now, it's been little explored. but this year, preparations were underway for a major new mission. this is the spacecraft called bepicolombo after a famous italian scientist — its launc

spark therapeutics has developed a new gene therapy which has the potential to treat l c a disease that causes rapid visual degeneration were blindness the drug name was. tarn it is a huge leap forward in finding the cure for blindness however the transformative genetic treatment will come with a price tag of four hundred twenty five thousand dollars per eye or double that for both after approved by the u.s. food and drug administration sparks said it will offer discounts based on whether or not the drug works initially and remains effective for the estimated one thousand to two thousand patients in the united states with this rare form of eye disease caused by a mutant gene and sparks shares continue to experience gains in the stock market and the company has formed multiple agreements with insurance companies on how to best provide those who suffer from this rare form of blindness a potential cure with what approach is fairly straightforward and eye surgeon makes a small incision in the eye and the treatment is infused onto the retina and the hope is that they'll take a single treatme

so after the gene therapy, i can move around the stage freely. i can see. i actually had confidence. >> spark has come up with new payment options such as rebates or payment plans insurers so often the case had have the final say on any out of pocket expenses. >>> breaking news out of burlington county. sky fox we go police say a man was stabbed in the stomach walking to the health center in moorestown as you can see we're over the scene right now. a lot of action there. this is princeton house behavioral health on new albany road. medics are treating the victim right now. we don't know anything bout somebody who did it. of course, as more information comes in, we will immediately bring it to you. >>> a woman rushed to hospital in bucks county. doctors said to live they needed to night her to philadelphia. her bill, enormous. and speaking of big, we've got a big day around the corner, sean. >> we do. the sixers had a big game in london across the upon. they had 22-point lead in this one but as you know life comes they had 22-point lead in this one but as yo

it's a stunning gene editing technique. the gene is getting edited and the dna is taken out. the next step, replace it with a different gene to fix a bad genetic mutation. >> changing biology and changing the world. >> reporter: in the future, it may be used to permanently tweak or change disease-causing genes in an embryo. the concern, that it will also be used to enhance babies. for example, making them smarter or stronger. >> that's a world we don't want to live in. >> reporter: this woman is executive director of the center for genetics and society in berkeley. she questions if parents will feel pressured to genetically engineer their offspring. >> so they can get into the right preschool and the right grade school and the right college. we already live with that. do we want to amp it up even more? >> reporter: as for sadie's mother, she prefers mother nature but imagines the pressure. >> someone like me decides to let "mother nature" you know take the lead, is that child going to be at a disadvantage? >> the doctor cautions that before this technology is used, experts ne

they get tested, they find they have the faulty gene, they don't have breast cancer.bubble mastectomy then. this is totally separate from that. so that will probably continue. there is one limitation on the study. only about 5% of breast cancer cases occur in that very young age group. we don't know about the long—term survival of women with breast cancer who get it at a much older age, more commonly at menopause or later. a surgeon who marked his initials on the livers of two patients has been fined £10,000 and given a i2—month community order. simon bramhall pleaded guilty to two counts of assault by beating in december. sima kotecha reports. simon bramhall, once a respected surgeon, now a convicted criminal. today he was given a £10,000 fine and a community service order after pleading guilty to assaulting two patients by marking his initials on their livers. his victims were undergoing liver transplants at the time. it was here, at the queen elizabeth hospital in birmingham, where he committed his offences. he marked the livers in 2013 and a year later, after a di

hot they're not what we call fate genes. they are risk genes.becoming increasingly urgent. more veterans die from suicide than in combat. but ptsd affects far more civilians, one of four of us will suffer some form of mental disorder in our lifetimes. ken's family could not be spared the tragedy of mental illness, but he helps others might benefit from paula's death. this is a great picture. one of the things that we tried to do at her funeral was really to celebrate her life. one of the things i'm celebrating about her life is that she's doing something now for science and other people in the future. i feel in my case, i feel very positive about that. jane o'brien, bbc news, maryland. donald trump is ubiquitous, loud and opinionated. his wife melania is the opposite. she rarely speaks in public and is seen far more than she's heard. she always looks immaculate but hasn't yet thrown herself into any particular causes. she is a very different first lady from her recent predecessors. melania trump has spent her first year communicating support for

gene: it can fire on those -- on both cylinders.f you look at the bang for your buck, your phone is the highest utility that you are going to get for any technology. i think people recognize that. even though that is a big number, $1000, i think people recognize the value bet they are getting. david: what about overseas? china has been a big target for apple. there has been thought that when you get up to those kind of prices, it will get crowded because there are a lot of cheaper competitors over there. do we have a sense of how they are doing, for example, in china? gene: don't have as good of a sense there. it has been boom or bust. the iphone 6 cycle, they did exceptionally well in china, and the last two years has been more difficult. i suspect the first days of the iphone x is going to do well in china, but then competition will probably chip away. cory: that was gene munster speaking to david westin and alix steel on bloomberg daybreak: americas. coming up, big tech, big gains. facebook, google, amazon all saw double-digit ga

for those crucial clinical trials like those from sparks their picks in developing what's turning a gene therapy in help finding a cure for blindness you know a great example is far therapeutics which just got approval to cure for this cure for l.c.a. i mean that started with the relationship between the gene and the condition in one thousand nine hundred four it went into the into a very noteworthy patient corey haas in two thousand and seven and then after ten years of clinical trials it's now available so it really is a want process and many brothers continue to inspire through their research and their personal funding in finding a cure for blindness reporting from washington d.c. david miller r t america. you know. there be like this is the great i'm not you know make an advertisement for this drug but i think that the fact that we're at a stage where for.

new advancements bailey yesterday artie's david miller brought us the news of blacks turned on new gene therapy drug now now with hopes of a new. cure on the horizon two brothers are out to make a difference while raising funds to offset the cost of the research and medical advancement artie's david miller story. kyra bather mission to raise awareness and help other victims the many brothers created to blind brothers using their sense of touch to create a clothing company to help find a cure for blindness at a young age brian and bradford manning were diagnosed with an eye disease that causes blindness over time and blindness is a societal problem that causes problems and economic productivity and education and we wanted to do something for all of these preclinical researchers that are trying to cure blindness so we thought clothing would be a great conduit for that we launched in may of two thousand and sixteen and since then we were really lucky to get great attention on it and at the beginning of two thousand and seventeen we realized we had the ability to come over full time and ded

gene: we are not.p things as they are, but for some context, the money that they brought back -- they will bring back an incremental $214 billion. probably be will spent on buybacks, like you said. we will be hearing more about that when they report their march quarter. but they will also dabble within m&a. if you are going to guess the type -- we think it is less likely that they do something like netflix, which has been highly rumored, and more likely to do smaller acquisitions, like magic leap -- or something that makes a ton of sense for apple, a health and fitness company, pelaton. they have a software platform that runs as well. beads like the acquisition. those will be some acquisitions of the type of m&a. not blockbusters, but ones you could see neatly folded within apple. of that a big chunk will likely be spent on buybacks. that will lift the share price, because it lists the earnings-per-share. is there an urgency here for apple to deploy some of that cash for m&a's, because som everything i

gene simmons, welcome to hardtalk. thank you. wonderful being here. all front with you, promoting an image and a brand through both your music and your opinions? well, i mean, i think it's fair to say we all wake up and stand in front of a mirror and try to see how the rest of the world sees us. if your own shakespeare says "the whole world's a stage" then we're alljust players. i mean, all of us to some effect, we're alljust trying to figure out what to wear, what to say, and how to act, in some ways it is all real. the only time we are as honest and purely innocent without trying to figure out what anyone thinks is perhaps when we are at home alone and there is nobody there tojudge us. but as soon as you leave your home, people have something to say, look at, think about, and so on. so, of course, everything is all an act in the same way as you. you are a professional, but of course it's an act. ok, but as far as the music is concerned, there are people who say it was always about the front rather than the music. yeah, they don't care. i mean, take

it is very inefficient, and there are lots of other genetic methods, now, for studying genes and humansay that they will do this in china in a very ethical way, and they will continue with monkeys, but, there are rather, as far as we know, no scientist who wa nt to as far as we know, no scientist who want to clone newman ‘s. as far as we know, no scientist who want to clone newman 's. thank you, fergus. time for a look at the weather now. over the next you hours, storm georgina will be moving over. we will be left with a breezy evening and a breezy night across all parts. there will be a supply of showers, too, across northern parts. there will be some wintry nurse on high ground of scotland, maybe into the hills of the pennines, and then down into the worst hills, as well. the heaviest of the showers... the thursday, we see not too much sunshine. quite a bit of shower activity, and come the middle of the day, but further north than that, andindeed day, but further north than that, and indeed across the eastern side of england, it is not a bad day. temperatures will be up to at best ar

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. >> and gene, chuck schumer says this is one step at a time. this is let's get that vote in the senate. without the vote in the senate, we won't be able to put any pressure on the house. >> that's true. and they probably are 60 votes in the senate i think for the dreamers. the democrats' problem, as david said is they essentially are in the minority. and you don't get to run the senate if you're in the minority. that said, it's a whole lot easier to get it through the senate than it is to get it through the house. and what will paul ryan do if he just would allow a vote on a clean dream act in the house? it might well pass. but that will be with democrats and moderate republicans. that would not have the support of a majority, the majority, the hastert rule. and that's what he hews to and probably has to keep his job. the one thing we ought to keep in mind in term of the political ramifications of the shutdown is everything has a shelf life of three days these days. >> yes. >> so it will be so forgotten. >> what shutdown? >> exactly. by next mo